@article{8b6b6fba30d143e384ac31a5fe45db17,
title = "Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer",
abstract = "Genome-wide association studies have identified 16 germline single-nucleotide polymorphisms (SNPs) that are associated with colorectal cancer (CRC) incidence. We examined the relationship between these SNPs and survival of 2611 individuals with CRC, enrolled in 5 cohort studies. We used Cox regression analysis to associate SNPs with overall and CRC-specific survival times. The minor allele in rs4939827 (SMAD7) was associated with reduced overall survival (hazard ratio, 1.16; 95% confidence interval, 1.06-1.27; P =.002) and disease-specific survival (hazard ratio, 1.17; 95% confidence interval, 1.05-1.30; P =.005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.",
keywords = "Colon Cancer, GWAS, Genetic, Prognosis",
author = "Phipps, {Amanda I.} and Newcomb, {Polly A.} and Xabier Garcia-Albeniz and Hutter, {Carolyn M.} and Emily White and Fuchs, {Charles S.} and Aditi Hazra and Shuji Ogino and Hongmei Nan and Jing Ma and Campbell, {Peter T.} and Figueiredo, {Jane C.} and Ulrike Peters and Chan, {Andrew T.}",
note = "Funding Information: Funding This work was supported by the National Cancer Institute, National Institutes of Health, US Department of Health and Human Services ( U01 CA137088 to U.P.), and was supported in part by a training grant from the National Cancer Institute, National Institutes of Health, US Department of Health and Human Services ( R25 CA094880 to E.W., with funding for A.I.P. and C.M.H.). A.T.C. is a Damon Runyon Clinical Investigator. P.A.N. was supported by the National Institutes of Health, National Cancer Institute ( K05CA152715 ). Additional funding support for included individual studies was as follows: the Health Professionals' Follow-up Study was supported by the National Institutes of Health ( P01 CA 055075 to C.S.F., R01 137178 to A.T.C., and P50 CA 127003 to C.S.F.); the Nurses' Health Study was supported by the National Institutes of Health ( R01 137178 to A.T.C., P50 CA 127003 to C.S.F., and P01 CA 087969 to C.S.F.); the Physicians' Health Study was supported by the National Institutes of Health ( CA 42182 ); the VItamins And Lifestyle Study was supported in part by the National Institutes of Health ( K05 CA154337 to E.W.) from the National Cancer Institute and Office of Dietary Supplements; and the Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. Funding for the genome-wide scan of the Women's Health Initiative was provided by the National Cancer Institute, Institutes of Health, US Department of Health and Human Services ( R01 CA059045 to U.P.). ",
year = "2012",
month = jul,
doi = "10.1053/j.gastro.2012.04.052",
language = "English (US)",
volume = "143",
pages = "51--54.e4",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "1",
}
