Association between antiphospholipid antibodies and all-cause mortality among end-stage renal disease patients with and without SLE: A retrospective cohort study

Anna R. Broder, Wenzhu Bi Mowrey, Mimi Kim, Irina Murakhovskaya, Henny H. Billett, Joel Neugarten, Karen H. Costenbader, Chaim Putterman

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective. To investigate the association between the presence of aPL and/or LA and all-cause mortality among end-stage renal disease (ESRD) patients with and without SLE. Methods. We included ESRD patients>18 years old followed at an urban tertiary care centre between 1 January 2006 and 31 January 2014 who had aPL measured at least once after initiating haemodialysis. All SLE patients met ACR/SLICC criteria. APL/LA+ was defined as aCL IgG or IgM>40 IU, anti-b2glycoprotein1 IgG or IgM≫40 IU or LA+. Deaths as at 31 January 2014 were captured in the linked National Death Index data. Time to death was defined from the first aPL measurement. Results. We included 34 SLE ESRD and 64 non-SLE ESRD patients; 30 patients died during the study period. SLE ESRD patients were younger [40.4 (12.5) vs 51.9 (18.1) years, P = 0.001] and more were women (88.2% vs 54.7%, P

Original languageEnglish (US)
Pages (from-to)817-825
Number of pages9
JournalRheumatology
Volume55
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • Antiphospholipid antibodies
  • End stage
  • Haemodialysis
  • Lupus nephritis
  • Renal disease
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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