TY - JOUR
T1 - Association Between Alcohol Consumption and Both Osteoporotic Fracture and Bone Density
AU - Berg, Karina M.
AU - Kunins, Hillary V.
AU - Jackson, Jeffrey L.
AU - Nahvi, Shadi
AU - Chaudhry, Amina
AU - Harris, Kenneth A.
AU - Malik, Rubina
AU - Arnsten, Julia H.
N1 - Funding Information:
This study was funded by the Program of Research Integrating Substance Use in Mainstream Healthcare with support from the Robert Wood Johnson Foundation, National Institute on Drug Abuse (NIDA), and National Institute on Alcohol Abuse and Alcoholism (co-directors A. T. McLellan, PhD, and B. J. Turner, MD, MSEd). Additional support was provided by grants K23 DA021087 from the NIDA and the National Institute of Mental Health and a Robert Wood Johnson Foundation Physician Faculty Scholar Award to Dr Berg; grants R25 DA14551 and R01 DA015302 from the NIDA to Dr Arnsten; and a Center for AIDS Research grant (P30 AI51519) to the Albert Einstein College of Medicine of Yeshiva University from the National Institutes of Health. Clinical research study
PY - 2008/5
Y1 - 2008/5
N2 - Objective: Alcoholism is a risk factor for osteoporotic fractures and low bone density, but the effects of moderate alcohol consumption on bone are unknown. We performed a systematic review and meta-analysis to assess the associations between alcohol consumption and osteoporotic fractures, bone density and bone density loss over time, bone response to estrogen replacement, and bone remodeling. Methods: MEDLINE, Current Contents, PsychINFO, and Cochrane Libraries were searched for studies published before May 14, 2007. We assessed quality using the internal validity criteria of the US Preventive Services Task Force. Results: We pooled effect sizes for 2 specific outcomes (hip fracture and bone density) and synthesized data qualitatively for 4 outcomes (non-hip fracture, bone density loss over time, bone response to estrogen replacement, and bone remodeling). Compared with abstainers, persons consuming from more than 0.5 to 1.0 drinks per day had lower hip fracture risk (relative risk = 0.80 [95% confidence interval, 0.71-0.91]), and persons consuming more than 2 drinks per day had higher risk (relative risk = 1.39 [95% confidence interval, 1.08-1.79]). A linear relationship existed between femoral neck bone density and alcohol consumption. Because studies often combined moderate and heavier drinkers in a single category, we could not assess relative associations between alcohol consumption and bone density in moderate compared with heavy drinkers. Conclusion: Compared with abstainers and heavier drinkers, persons who consume 0.5 to 1.0 drink per day have a lower risk of hip fracture. Although available evidence suggests a favorable effect of alcohol consumption on bone density, a precise range of beneficial alcohol consumption cannot be determined.
AB - Objective: Alcoholism is a risk factor for osteoporotic fractures and low bone density, but the effects of moderate alcohol consumption on bone are unknown. We performed a systematic review and meta-analysis to assess the associations between alcohol consumption and osteoporotic fractures, bone density and bone density loss over time, bone response to estrogen replacement, and bone remodeling. Methods: MEDLINE, Current Contents, PsychINFO, and Cochrane Libraries were searched for studies published before May 14, 2007. We assessed quality using the internal validity criteria of the US Preventive Services Task Force. Results: We pooled effect sizes for 2 specific outcomes (hip fracture and bone density) and synthesized data qualitatively for 4 outcomes (non-hip fracture, bone density loss over time, bone response to estrogen replacement, and bone remodeling). Compared with abstainers, persons consuming from more than 0.5 to 1.0 drinks per day had lower hip fracture risk (relative risk = 0.80 [95% confidence interval, 0.71-0.91]), and persons consuming more than 2 drinks per day had higher risk (relative risk = 1.39 [95% confidence interval, 1.08-1.79]). A linear relationship existed between femoral neck bone density and alcohol consumption. Because studies often combined moderate and heavier drinkers in a single category, we could not assess relative associations between alcohol consumption and bone density in moderate compared with heavy drinkers. Conclusion: Compared with abstainers and heavier drinkers, persons who consume 0.5 to 1.0 drink per day have a lower risk of hip fracture. Although available evidence suggests a favorable effect of alcohol consumption on bone density, a precise range of beneficial alcohol consumption cannot be determined.
KW - Alcohol
KW - Bone mineral density
KW - Hip fracture
KW - Meta-analysis
KW - Osteoporosis
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U2 - 10.1016/j.amjmed.2007.12.012
DO - 10.1016/j.amjmed.2007.12.012
M3 - Article
C2 - 18456037
AN - SCOPUS:43049094836
SN - 0002-9343
VL - 121
SP - 406
EP - 418
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 5
ER -