Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Elizabeth K. Speliotes, Cristen J. Willer, Sonja I. Berndt, Keri L. Monda, Gudmar Thorleifsson, Anne U. Jackson, Hana Lango Allen, Cecilia M. Lindgren, Jian'An Luan, Reedik Mägi, Joshua C. Randall, Sailaja Vedantam, Thomas W. Winkler, Lu Qi, Tsegaselassie Workalemahu, Iris Heid, Valgerdur Steinthorsdottir, Heather Stringham, Michael N. Weedon, Eeleanor Wheeler & 356 others Andrew R. Wood, Teresa Ferreira, Robert J. Weyant, Ayellet V. Segrè, Karol Eestrada, Liming Liang, James Nemesh, Ju Hyun Park, Stefan Gustafsson, Tuomas O. Kilpeläinen, Jian Yang, Nabila Bouatia-Naji, Tõnu Eesko, Mary F. Feitosa, Zoltán Kutalik, Massimo Mangino, Soumya Raychaudhuri, Andre Scherag, Albert Vernon Smith, Ryan Welch, Jing Hua Zhao, Katja K. Aben, Devin M. Absher, Najaf Amin, Anna L. Dixon, Eeva Fisher, Nicole Glazer, Michael E. Goddard, Nancy Heard-Costa, Volker Hoesel, Jouke Jan Hottenga, Åsa Johansson, Toby Johnson, Shamika Ketkar, Claudia Lamina, Shengxu Li, Miriam F. Moffatt, Richard H. Myers, Narisu Narisu, John R B Perry, Marjolein J. Peters, Micheal Preuss, Samuli Ripatti, Fernando Rivadeneira, Camilla Sandholt, Laura J. Scott, Nicholas J. Timpson, Jonathan P. Tyrer, Sophie Van Wingerden, Richard Watanabe, Charles C. White, Fredrik Wiklund, Christina Barlassina, Daniel I. Chasman, Matthew N. Cooper, John Olov Jansson, Robert W. Lawrence, Niina Pellikka, Inga Prokopenko, Jianxin Shi, Eelisabeth Thiering, Helene Alavere, Maria T S Alibrandi, Peter Almgren, Alice Arnold, Thor Aspelund, Larry D. Atwood, Beverley Balkau, Anthony J. Balmforth, Amanda J. Bennett, Yoav Ben-Shlomo, Richard Bergman, Sven Bergmann, Heike Biebermann, Alexandra I F Blakemore, Tanja Boes, Lori Bonnycastle, Stefan R. Bornstein, Morris J. Brown, Thomas A. Buchanan, Fabio Busonero, Harry Campbell, Francesco P. Cappuccio, Christine Cavalcanti-Proença, Yii Dder Ida Chen, Chih Mei Chen, Peter Chines, Robert Clarke, Lachlan Coin, John Connell, Ian Day, Martin Den Heijer, Jubao Duan, Shah Eebrahim, Paul Eelliott, Roberto Eelosua, Gudny Eeiriksdottir, Micheal R. Eerdos, Johan G. Eeriksson, Maurizio F. Facheris, Stephan B. Felix, Pamela Fischer-Posovszky, Aaron R. Folsom, Nele Friedrich, Nelson B. Freimer, Mao Fu, Stefan Gaget, Pablo V. Gejman, Eeco J. Geus, Christian Gieger, Anette P. Gjesing, Anuj Goel, Philippe Goyette, Harald Grallert, Jürgen Gräßler, Danielle Greenawalt, Christopher J. Groves, Vilmundur Gudnason, Candace Guiducci, Anna Lliisa Hartikainen, Neelam Hassanali, Alistair Hall, Aki Havulinna, Caroline Hayward, Andrew Heath, Christian Hengstenberg, Andrew A. Hicks, Anke Hinney, Albert Hofman, Georg Homuth, Jennie Hui, Wilmar Igl, Carlos Iribarren, Bo Isomaa, Kevin B. Jacobs, Ivonne Jarick, Eelizabeth Jewell, Ulrich John, Torben Jørgensen, Pekka Jousilahti, Antti Jula, Marika Kaakinen, Eeero Kajantie, Lee Kaplan, Sekar Kathiresan, Johannes Kettunen, Leena Kinnunen, Joshua Knowles, Ivana Kolcic, Inke R. König, Seppo Koskinen, Peter Kovacs, Johanna Kusisto, Peter Kraft, Kirsti Kvaløy, Jaana Laitinen, Olivier Lantieri, Chiara Lanzani, Lenore J. Launer, Cecile Lecoeur, Terho Lehtimäki, Guillaume Lettre, Jianjun Liu, Marja Lissa Lokki, Mattias Lorentzon, Robert Luben, Barbara Ludwig, Magic, Paolo Manunta, Diana Marek, Michel Marre, Nicholas G. Martin, Wendy McArdle, Anne McCarthy, Barbara McKnight, Thomas Meitinger, Olle Melander, David Meyre, Kristian Midthjell, Grant Montgomery, Mario A. Morken, Andrew P. Morris, Rosanda Mulic, Julius Ngwa, Mari Nelis, Matt J. Neville, Dale R. Nyholt, Christopher J. O'Ddonnell, Stephen O'Rahilly, Ken Ong, Ben Ostra, Guillaume Paré, Alex Parker, Markus Perola, Irene Pichler, Kirsi H. Pietiläinen, Carl P. Platou, Ozren Polasek, Anneli Pouta, Suzanne Rafelt, Olli Raitakari, Nigel Rayner, Martin Ridderstråle, Winfried Rief, Aimo Ruokonen, Neil R. Robertson, Peter Rzehak, Veikko Salomaa, Alan R. Sanders, Manjinder Sandhu, Serena Sanna, Jouko Saramies, Markku J. Savolainen, Susann Scherag, Sabine Schipf, Stefan Schreiber, Heribert Schunkert, Kaisa Silander, Juha Sinisalo, David S. Siscovick, Jan H. Smit, Nicole Soranzo, Ulla Sovio, Jonathan Stephens, Ida Surakka, Amy J. Swift, Mari Lliis Tammesoo, Jean Claude Tardif, Maris Teder-Laving, Tanya Teslovich, John R. Thompson, Brian Thomson, Anke Tönjes, Tiinamaija Tuomi, Joyce B J Van Meurs, Gert Jan Van OMen, Vincent Vatin, Jorma Viikari, Sophie Visvikis-Siest, Veronique Vitart, Carla I. Vogel, Benjamin F. Voight, Lindsay Waite, Henri Wallaschofski, Bragi Walters, Elisabeth Widen, Susanna Wiegand, Sarah H. Wild, Gonneke Willemsen, Deniel R. Witte, Jacqueline Witteman, Jianfeng Xu, Qunyuan Zhang, Lina Zgaga, Andreas Ziegler, Paavo Zitting, John P. Beilby, I. Ssadaf FarOqi, Johannes Hebebrand, Heikki V. Huikuri, Alan James, Mika Kähönen, Douglas F. Levinson, Fabio MacCiardi, Markku S. Nieminen, Claes Ohlsson, Lyle J. Palmer, Paul Ridker, Micheal Stumvoll, Jacques Beckmann, Heiner Boeing, Eeric Boerwinkle, Dorret I. BOmsma, Mark J. Caulfield, Stephan J. Chanock, Francis Collins, L. Adrienne Cupples, George Davey Smith, Jeanette Eerdmann, Philippe Frogue, Henrik Grönberg, Ulf Gyllensten, Per Hall, Torben Hansen, Tamara B. Harris, Andrew T. Hattersley, Richard B. Hayes, Joachim Heinrich, Frank B. Hu, Kristian Hveem, Thomas Illig, Marjo Riitta Jarvelin, Jaakko Kaprio, Fredrik Karpe, Kay Ttee Khaw, Lambertus A. Kiemeney, Heiko Krude, Markku Laakso, Debbie A. Lawlor, Andres Metspalu, Patricia B. Munroe, Willem H. Ouwehand, Oluf Pedersen, Brenda W. Penninx, Annette Peters, Peter P. Pramstaller, Thomas Quertermous, Thomas Reinehr, Aila Rissanen, Igor Rudan, Nilesh J. Samani, Peter E H Schwarz, Alan R. Shuldiner, Timothy D. Spector, Jaakko Tuomilehto, Manuela Uda, André Uitterlinden, Timo Valle, Martin Wabitsch, Gérard Waeber, Nicholas J. Wareham, Hugh Watkins, James F. Wilson, Alan F. Wright, M. Ccarola Zillikens, Nilanjan ChatterjE, Steven A. McCarroll, Shaun Purcell, Eric Schadt, Peter Visscher, Themistocles L. Assimes, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Leif C. Groop, Talin Haritunians, David J. Hunter, Robert C. Kaplan, Karen Mohlke, Jeffrey R. O'ConneL, Leena Peltonen, David SchleSinger, David P. P Strachan, Cornelia Van Duijn, H. Erich Wichmann, Timothy M. Frayling, Unnur Thorsteinsdottir, Gonçalo R. Abecasis, Inês Barroso, Michael Boehnke, Kari StefanSon, Kari E. North, Mark I. McArthy, Joel N. Hirschhorn, Erik IngelSon, Ruth J F Loos

Research output: Contribution to journalArticle

1828 Citations (Scopus)

Abstract

Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.

Original languageEnglish (US)
Pages (from-to)937-948
Number of pages12
JournalNature Genetics
Volume42
Issue number11
DOIs
StatePublished - Nov 2010

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Body Mass Index
Obesity
Single Nucleotide Polymorphism
Incretins
Pro-Opiomelanocortin
Genetic Loci
Brain-Derived Neurotrophic Factor
Human Body
Body Weight
Genes
methanohexohydroisoindoline ethylguanidine hemisulfate

ASJC Scopus subject areas

  • Genetics

Cite this

Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., ... Loos, R. J. F. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42(11), 937-948. https://doi.org/10.1038/ng.686

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. / Speliotes, Elizabeth K.; Willer, Cristen J.; Berndt, Sonja I.; Monda, Keri L.; Thorleifsson, Gudmar; Jackson, Anne U.; Allen, Hana Lango; Lindgren, Cecilia M.; Luan, Jian'An; Mägi, Reedik; Randall, Joshua C.; Vedantam, Sailaja; Winkler, Thomas W.; Qi, Lu; Workalemahu, Tsegaselassie; Heid, Iris; Steinthorsdottir, Valgerdur; Stringham, Heather; Weedon, Michael N.; Wheeler, Eeleanor; Wood, Andrew R.; Ferreira, Teresa; Weyant, Robert J.; Segrè, Ayellet V.; Eestrada, Karol; Liang, Liming; Nemesh, James; Park, Ju Hyun; Gustafsson, Stefan; Kilpeläinen, Tuomas O.; Yang, Jian; Bouatia-Naji, Nabila; Eesko, Tõnu; Feitosa, Mary F.; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Smith, Albert Vernon; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K.; Absher, Devin M.; Amin, Najaf; Dixon, Anna L.; Fisher, Eeva; Glazer, Nicole; Goddard, Michael E.; Heard-Costa, Nancy; Hoesel, Volker; Hottenga, Jouke Jan; Johansson, Åsa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, Shengxu; Moffatt, Miriam F.; Myers, Richard H.; Narisu, Narisu; Perry, John R B; Peters, Marjolein J.; Preuss, Micheal; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla; Scott, Laura J.; Timpson, Nicholas J.; Tyrer, Jonathan P.; Van Wingerden, Sophie; Watanabe, Richard; White, Charles C.; Wiklund, Fredrik; Barlassina, Christina; Chasman, Daniel I.; Cooper, Matthew N.; Jansson, John Olov; Lawrence, Robert W.; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Eelisabeth; Alavere, Helene; Alibrandi, Maria T S; Almgren, Peter; Arnold, Alice; Aspelund, Thor; Atwood, Larry D.; Balkau, Beverley; Balmforth, Anthony J.; Bennett, Amanda J.; Ben-Shlomo, Yoav; Bergman, Richard; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I F; Boes, Tanja; Bonnycastle, Lori; Bornstein, Stefan R.; Brown, Morris J.; Buchanan, Thomas A.; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P.; Cavalcanti-Proença, Christine; Ida Chen, Yii Dder; Chen, Chih Mei; Chines, Peter; Clarke, Robert; Coin, Lachlan; Connell, John; Day, Ian; Den Heijer, Martin; Duan, Jubao; Eebrahim, Shah; Eelliott, Paul; Eelosua, Roberto; Eeiriksdottir, Gudny; Eerdos, Micheal R.; Eeriksson, Johan G.; Facheris, Maurizio F.; Felix, Stephan B.; Fischer-Posovszky, Pamela; Folsom, Aaron R.; Friedrich, Nele; Freimer, Nelson B.; Fu, Mao; Gaget, Stefan; Gejman, Pablo V.; Geus, Eeco J.; Gieger, Christian; Gjesing, Anette P.; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Gräßler, Jürgen; Greenawalt, Danielle; Groves, Christopher J.; Gudnason, Vilmundur; Guiducci, Candace; Hartikainen, Anna Lliisa; Hassanali, Neelam; Hall, Alistair; Havulinna, Aki; Hayward, Caroline; Heath, Andrew; Hengstenberg, Christian; Hicks, Andrew A.; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; Jacobs, Kevin B.; Jarick, Ivonne; Jewell, Eelizabeth; John, Ulrich; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eeero; Kaplan, Lee; Kathiresan, Sekar; Kettunen, Johannes; Kinnunen, Leena; Knowles, Joshua; Kolcic, Ivana; König, Inke R.; Koskinen, Seppo; Kovacs, Peter; Kusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J.; Lecoeur, Cecile; Lehtimäki, Terho; Lettre, Guillaume; Liu, Jianjun; Lokki, Marja Lissa; Lorentzon, Mattias; Luben, Robert; Ludwig, Barbara; Magic; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G.; McArdle, Wendy; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; Montgomery, Grant; Morken, Mario A.; Morris, Andrew P.; Mulic, Rosanda; Ngwa, Julius; Nelis, Mari; Neville, Matt J.; Nyholt, Dale R.; O'Ddonnell, Christopher J.; O'Rahilly, Stephen; Ong, Ken; Ostra, Ben; Paré, Guillaume; Parker, Alex; Perola, Markus; Pichler, Irene; Pietiläinen, Kirsi H.; Platou, Carl P.; Polasek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel; Ridderstråle, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R.; Rzehak, Peter; Salomaa, Veikko; Sanders, Alan R.; Sandhu, Manjinder; Sanna, Serena; Saramies, Jouko; Savolainen, Markku J.; Scherag, Susann; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; Siscovick, David S.; Smit, Jan H.; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J.; Tammesoo, Mari Lliis; Tardif, Jean Claude; Teder-Laving, Maris; Teslovich, Tanya; Thompson, John R.; Thomson, Brian; Tönjes, Anke; Tuomi, Tiinamaija; Van Meurs, Joyce B J; Van OMen, Gert Jan; Vatin, Vincent; Viikari, Jorma; Visvikis-Siest, Sophie; Vitart, Veronique; Vogel, Carla I.; Voight, Benjamin F.; Waite, Lindsay; Wallaschofski, Henri; Walters, Bragi; Widen, Elisabeth; Wiegand, Susanna; Wild, Sarah H.; Willemsen, Gonneke; Witte, Deniel R.; Witteman, Jacqueline; Xu, Jianfeng; Zhang, Qunyuan; Zgaga, Lina; Ziegler, Andreas; Zitting, Paavo; Beilby, John P.; FarOqi, I. Ssadaf; Hebebrand, Johannes; Huikuri, Heikki V.; James, Alan; Kähönen, Mika; Levinson, Douglas F.; MacCiardi, Fabio; Nieminen, Markku S.; Ohlsson, Claes; Palmer, Lyle J.; Ridker, Paul; Stumvoll, Micheal; Beckmann, Jacques; Boeing, Heiner; Boerwinkle, Eeric; BOmsma, Dorret I.; Caulfield, Mark J.; Chanock, Stephan J.; Collins, Francis; Cupples, L. Adrienne; Smith, George Davey; Eerdmann, Jeanette; Frogue, Philippe; Grönberg, Henrik; Gyllensten, Ulf; Hall, Per; Hansen, Torben; Harris, Tamara B.; Hattersley, Andrew T.; Hayes, Richard B.; Heinrich, Joachim; Hu, Frank B.; Hveem, Kristian; Illig, Thomas; Jarvelin, Marjo Riitta; Kaprio, Jaakko; Karpe, Fredrik; Khaw, Kay Ttee; Kiemeney, Lambertus A.; Krude, Heiko; Laakso, Markku; Lawlor, Debbie A.; Metspalu, Andres; Munroe, Patricia B.; Ouwehand, Willem H.; Pedersen, Oluf; Penninx, Brenda W.; Peters, Annette; Pramstaller, Peter P.; Quertermous, Thomas; Reinehr, Thomas; Rissanen, Aila; Rudan, Igor; Samani, Nilesh J.; Schwarz, Peter E H; Shuldiner, Alan R.; Spector, Timothy D.; Tuomilehto, Jaakko; Uda, Manuela; Uitterlinden, André; Valle, Timo; Wabitsch, Martin; Waeber, Gérard; Wareham, Nicholas J.; Watkins, Hugh; Wilson, James F.; Wright, Alan F.; Zillikens, M. Ccarola; ChatterjE, Nilanjan; McCarroll, Steven A.; Purcell, Shaun; Schadt, Eric; Visscher, Peter; Assimes, Themistocles L.; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Groop, Leif C.; Haritunians, Talin; Hunter, David J.; Kaplan, Robert C.; Mohlke, Karen; O'ConneL, Jeffrey R.; Peltonen, Leena; SchleSinger, David; P Strachan, David P.; Van Duijn, Cornelia; Wichmann, H. Erich; Frayling, Timothy M.; Thorsteinsdottir, Unnur; Abecasis, Gonçalo R.; Barroso, Inês; Boehnke, Michael; StefanSon, Kari; North, Kari E.; McArthy, Mark I.; Hirschhorn, Joel N.; IngelSon, Erik; Loos, Ruth J F.

In: Nature Genetics, Vol. 42, No. 11, 11.2010, p. 937-948.

Research output: Contribution to journalArticle

Speliotes, EK, Willer, CJ, Berndt, SI, Monda, KL, Thorleifsson, G, Jackson, AU, Allen, HL, Lindgren, CM, Luan, JA, Mägi, R, Randall, JC, Vedantam, S, Winkler, TW, Qi, L, Workalemahu, T, Heid, I, Steinthorsdottir, V, Stringham, H, Weedon, MN, Wheeler, E, Wood, AR, Ferreira, T, Weyant, RJ, Segrè, AV, Eestrada, K, Liang, L, Nemesh, J, Park, JH, Gustafsson, S, Kilpeläinen, TO, Yang, J, Bouatia-Naji, N, Eesko, T, Feitosa, MF, Kutalik, Z, Mangino, M, Raychaudhuri, S, Scherag, A, Smith, AV, Welch, R, Zhao, JH, Aben, KK, Absher, DM, Amin, N, Dixon, AL, Fisher, E, Glazer, N, Goddard, ME, Heard-Costa, N, Hoesel, V, Hottenga, JJ, Johansson, Å, Johnson, T, Ketkar, S, Lamina, C, Li, S, Moffatt, MF, Myers, RH, Narisu, N, Perry, JRB, Peters, MJ, Preuss, M, Ripatti, S, Rivadeneira, F, Sandholt, C, Scott, LJ, Timpson, NJ, Tyrer, JP, Van Wingerden, S, Watanabe, R, White, CC, Wiklund, F, Barlassina, C, Chasman, DI, Cooper, MN, Jansson, JO, Lawrence, RW, Pellikka, N, Prokopenko, I, Shi, J, Thiering, E, Alavere, H, Alibrandi, MTS, Almgren, P, Arnold, A, Aspelund, T, Atwood, LD, Balkau, B, Balmforth, AJ, Bennett, AJ, Ben-Shlomo, Y, Bergman, R, Bergmann, S, Biebermann, H, Blakemore, AIF, Boes, T, Bonnycastle, L, Bornstein, SR, Brown, MJ, Buchanan, TA, Busonero, F, Campbell, H, Cappuccio, FP, Cavalcanti-Proença, C, Ida Chen, YD, Chen, CM, Chines, P, Clarke, R, Coin, L, Connell, J, Day, I, Den Heijer, M, Duan, J, Eebrahim, S, Eelliott, P, Eelosua, R, Eeiriksdottir, G, Eerdos, MR, Eeriksson, JG, Facheris, MF, Felix, SB, Fischer-Posovszky, P, Folsom, AR, Friedrich, N, Freimer, NB, Fu, M, Gaget, S, Gejman, PV, Geus, EJ, Gieger, C, Gjesing, AP, Goel, A, Goyette, P, Grallert, H, Gräßler, J, Greenawalt, D, Groves, CJ, Gudnason, V, Guiducci, C, Hartikainen, AL, Hassanali, N, Hall, A, Havulinna, A, Hayward, C, Heath, A, Hengstenberg, C, Hicks, AA, Hinney, A, Hofman, A, Homuth, G, Hui, J, Igl, W, Iribarren, C, Isomaa, B, Jacobs, KB, Jarick, I, Jewell, E, John, U, Jørgensen, T, Jousilahti, P, Jula, A, Kaakinen, M, Kajantie, E, Kaplan, L, Kathiresan, S, Kettunen, J, Kinnunen, L, Knowles, J, Kolcic, I, König, IR, Koskinen, S, Kovacs, P, Kusisto, J, Kraft, P, Kvaløy, K, Laitinen, J, Lantieri, O, Lanzani, C, Launer, LJ, Lecoeur, C, Lehtimäki, T, Lettre, G, Liu, J, Lokki, ML, Lorentzon, M, Luben, R, Ludwig, B, Magic, Manunta, P, Marek, D, Marre, M, Martin, NG, McArdle, W, McCarthy, A, McKnight, B, Meitinger, T, Melander, O, Meyre, D, Midthjell, K, Montgomery, G, Morken, MA, Morris, AP, Mulic, R, Ngwa, J, Nelis, M, Neville, MJ, Nyholt, DR, O'Ddonnell, CJ, O'Rahilly, S, Ong, K, Ostra, B, Paré, G, Parker, A, Perola, M, Pichler, I, Pietiläinen, KH, Platou, CP, Polasek, O, Pouta, A, Rafelt, S, Raitakari, O, Rayner, N, Ridderstråle, M, Rief, W, Ruokonen, A, Robertson, NR, Rzehak, P, Salomaa, V, Sanders, AR, Sandhu, M, Sanna, S, Saramies, J, Savolainen, MJ, Scherag, S, Schipf, S, Schreiber, S, Schunkert, H, Silander, K, Sinisalo, J, Siscovick, DS, Smit, JH, Soranzo, N, Sovio, U, Stephens, J, Surakka, I, Swift, AJ, Tammesoo, ML, Tardif, JC, Teder-Laving, M, Teslovich, T, Thompson, JR, Thomson, B, Tönjes, A, Tuomi, T, Van Meurs, JBJ, Van OMen, GJ, Vatin, V, Viikari, J, Visvikis-Siest, S, Vitart, V, Vogel, CI, Voight, BF, Waite, L, Wallaschofski, H, Walters, B, Widen, E, Wiegand, S, Wild, SH, Willemsen, G, Witte, DR, Witteman, J, Xu, J, Zhang, Q, Zgaga, L, Ziegler, A, Zitting, P, Beilby, JP, FarOqi, IS, Hebebrand, J, Huikuri, HV, James, A, Kähönen, M, Levinson, DF, MacCiardi, F, Nieminen, MS, Ohlsson, C, Palmer, LJ, Ridker, P, Stumvoll, M, Beckmann, J, Boeing, H, Boerwinkle, E, BOmsma, DI, Caulfield, MJ, Chanock, SJ, Collins, F, Cupples, LA, Smith, GD, Eerdmann, J, Frogue, P, Grönberg, H, Gyllensten, U, Hall, P, Hansen, T, Harris, TB, Hattersley, AT, Hayes, RB, Heinrich, J, Hu, FB, Hveem, K, Illig, T, Jarvelin, MR, Kaprio, J, Karpe, F, Khaw, KT, Kiemeney, LA, Krude, H, Laakso, M, Lawlor, DA, Metspalu, A, Munroe, PB, Ouwehand, WH, Pedersen, O, Penninx, BW, Peters, A, Pramstaller, PP, Quertermous, T, Reinehr, T, Rissanen, A, Rudan, I, Samani, NJ, Schwarz, PEH, Shuldiner, AR, Spector, TD, Tuomilehto, J, Uda, M, Uitterlinden, A, Valle, T, Wabitsch, M, Waeber, G, Wareham, NJ, Watkins, H, Wilson, JF, Wright, AF, Zillikens, MC, ChatterjE, N, McCarroll, SA, Purcell, S, Schadt, E, Visscher, P, Assimes, TL, Borecki, IB, Deloukas, P, Fox, CS, Groop, LC, Haritunians, T, Hunter, DJ, Kaplan, RC, Mohlke, K, O'ConneL, JR, Peltonen, L, SchleSinger, D, P Strachan, DP, Van Duijn, C, Wichmann, HE, Frayling, TM, Thorsteinsdottir, U, Abecasis, GR, Barroso, I, Boehnke, M, StefanSon, K, North, KE, McArthy, MI, Hirschhorn, JN, IngelSon, E & Loos, RJF 2010, 'Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index', Nature Genetics, vol. 42, no. 11, pp. 937-948. https://doi.org/10.1038/ng.686
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics. 2010 Nov;42(11):937-948. https://doi.org/10.1038/ng.686
Speliotes, Elizabeth K. ; Willer, Cristen J. ; Berndt, Sonja I. ; Monda, Keri L. ; Thorleifsson, Gudmar ; Jackson, Anne U. ; Allen, Hana Lango ; Lindgren, Cecilia M. ; Luan, Jian'An ; Mägi, Reedik ; Randall, Joshua C. ; Vedantam, Sailaja ; Winkler, Thomas W. ; Qi, Lu ; Workalemahu, Tsegaselassie ; Heid, Iris ; Steinthorsdottir, Valgerdur ; Stringham, Heather ; Weedon, Michael N. ; Wheeler, Eeleanor ; Wood, Andrew R. ; Ferreira, Teresa ; Weyant, Robert J. ; Segrè, Ayellet V. ; Eestrada, Karol ; Liang, Liming ; Nemesh, James ; Park, Ju Hyun ; Gustafsson, Stefan ; Kilpeläinen, Tuomas O. ; Yang, Jian ; Bouatia-Naji, Nabila ; Eesko, Tõnu ; Feitosa, Mary F. ; Kutalik, Zoltán ; Mangino, Massimo ; Raychaudhuri, Soumya ; Scherag, Andre ; Smith, Albert Vernon ; Welch, Ryan ; Zhao, Jing Hua ; Aben, Katja K. ; Absher, Devin M. ; Amin, Najaf ; Dixon, Anna L. ; Fisher, Eeva ; Glazer, Nicole ; Goddard, Michael E. ; Heard-Costa, Nancy ; Hoesel, Volker ; Hottenga, Jouke Jan ; Johansson, Åsa ; Johnson, Toby ; Ketkar, Shamika ; Lamina, Claudia ; Li, Shengxu ; Moffatt, Miriam F. ; Myers, Richard H. ; Narisu, Narisu ; Perry, John R B ; Peters, Marjolein J. ; Preuss, Micheal ; Ripatti, Samuli ; Rivadeneira, Fernando ; Sandholt, Camilla ; Scott, Laura J. ; Timpson, Nicholas J. ; Tyrer, Jonathan P. ; Van Wingerden, Sophie ; Watanabe, Richard ; White, Charles C. ; Wiklund, Fredrik ; Barlassina, Christina ; Chasman, Daniel I. ; Cooper, Matthew N. ; Jansson, John Olov ; Lawrence, Robert W. ; Pellikka, Niina ; Prokopenko, Inga ; Shi, Jianxin ; Thiering, Eelisabeth ; Alavere, Helene ; Alibrandi, Maria T S ; Almgren, Peter ; Arnold, Alice ; Aspelund, Thor ; Atwood, Larry D. ; Balkau, Beverley ; Balmforth, Anthony J. ; Bennett, Amanda J. ; Ben-Shlomo, Yoav ; Bergman, Richard ; Bergmann, Sven ; Biebermann, Heike ; Blakemore, Alexandra I F ; Boes, Tanja ; Bonnycastle, Lori ; Bornstein, Stefan R. ; Brown, Morris J. ; Buchanan, Thomas A. ; Busonero, Fabio ; Campbell, Harry ; Cappuccio, Francesco P. ; Cavalcanti-Proença, Christine ; Ida Chen, Yii Dder ; Chen, Chih Mei ; Chines, Peter ; Clarke, Robert ; Coin, Lachlan ; Connell, John ; Day, Ian ; Den Heijer, Martin ; Duan, Jubao ; Eebrahim, Shah ; Eelliott, Paul ; Eelosua, Roberto ; Eeiriksdottir, Gudny ; Eerdos, Micheal R. ; Eeriksson, Johan G. ; Facheris, Maurizio F. ; Felix, Stephan B. ; Fischer-Posovszky, Pamela ; Folsom, Aaron R. ; Friedrich, Nele ; Freimer, Nelson B. ; Fu, Mao ; Gaget, Stefan ; Gejman, Pablo V. ; Geus, Eeco J. ; Gieger, Christian ; Gjesing, Anette P. ; Goel, Anuj ; Goyette, Philippe ; Grallert, Harald ; Gräßler, Jürgen ; Greenawalt, Danielle ; Groves, Christopher J. ; Gudnason, Vilmundur ; Guiducci, Candace ; Hartikainen, Anna Lliisa ; Hassanali, Neelam ; Hall, Alistair ; Havulinna, Aki ; Hayward, Caroline ; Heath, Andrew ; Hengstenberg, Christian ; Hicks, Andrew A. ; Hinney, Anke ; Hofman, Albert ; Homuth, Georg ; Hui, Jennie ; Igl, Wilmar ; Iribarren, Carlos ; Isomaa, Bo ; Jacobs, Kevin B. ; Jarick, Ivonne ; Jewell, Eelizabeth ; John, Ulrich ; Jørgensen, Torben ; Jousilahti, Pekka ; Jula, Antti ; Kaakinen, Marika ; Kajantie, Eeero ; Kaplan, Lee ; Kathiresan, Sekar ; Kettunen, Johannes ; Kinnunen, Leena ; Knowles, Joshua ; Kolcic, Ivana ; König, Inke R. ; Koskinen, Seppo ; Kovacs, Peter ; Kusisto, Johanna ; Kraft, Peter ; Kvaløy, Kirsti ; Laitinen, Jaana ; Lantieri, Olivier ; Lanzani, Chiara ; Launer, Lenore J. ; Lecoeur, Cecile ; Lehtimäki, Terho ; Lettre, Guillaume ; Liu, Jianjun ; Lokki, Marja Lissa ; Lorentzon, Mattias ; Luben, Robert ; Ludwig, Barbara ; Magic ; Manunta, Paolo ; Marek, Diana ; Marre, Michel ; Martin, Nicholas G. ; McArdle, Wendy ; McCarthy, Anne ; McKnight, Barbara ; Meitinger, Thomas ; Melander, Olle ; Meyre, David ; Midthjell, Kristian ; Montgomery, Grant ; Morken, Mario A. ; Morris, Andrew P. ; Mulic, Rosanda ; Ngwa, Julius ; Nelis, Mari ; Neville, Matt J. ; Nyholt, Dale R. ; O'Ddonnell, Christopher J. ; O'Rahilly, Stephen ; Ong, Ken ; Ostra, Ben ; Paré, Guillaume ; Parker, Alex ; Perola, Markus ; Pichler, Irene ; Pietiläinen, Kirsi H. ; Platou, Carl P. ; Polasek, Ozren ; Pouta, Anneli ; Rafelt, Suzanne ; Raitakari, Olli ; Rayner, Nigel ; Ridderstråle, Martin ; Rief, Winfried ; Ruokonen, Aimo ; Robertson, Neil R. ; Rzehak, Peter ; Salomaa, Veikko ; Sanders, Alan R. ; Sandhu, Manjinder ; Sanna, Serena ; Saramies, Jouko ; Savolainen, Markku J. ; Scherag, Susann ; Schipf, Sabine ; Schreiber, Stefan ; Schunkert, Heribert ; Silander, Kaisa ; Sinisalo, Juha ; Siscovick, David S. ; Smit, Jan H. ; Soranzo, Nicole ; Sovio, Ulla ; Stephens, Jonathan ; Surakka, Ida ; Swift, Amy J. ; Tammesoo, Mari Lliis ; Tardif, Jean Claude ; Teder-Laving, Maris ; Teslovich, Tanya ; Thompson, John R. ; Thomson, Brian ; Tönjes, Anke ; Tuomi, Tiinamaija ; Van Meurs, Joyce B J ; Van OMen, Gert Jan ; Vatin, Vincent ; Viikari, Jorma ; Visvikis-Siest, Sophie ; Vitart, Veronique ; Vogel, Carla I. ; Voight, Benjamin F. ; Waite, Lindsay ; Wallaschofski, Henri ; Walters, Bragi ; Widen, Elisabeth ; Wiegand, Susanna ; Wild, Sarah H. ; Willemsen, Gonneke ; Witte, Deniel R. ; Witteman, Jacqueline ; Xu, Jianfeng ; Zhang, Qunyuan ; Zgaga, Lina ; Ziegler, Andreas ; Zitting, Paavo ; Beilby, John P. ; FarOqi, I. Ssadaf ; Hebebrand, Johannes ; Huikuri, Heikki V. ; James, Alan ; Kähönen, Mika ; Levinson, Douglas F. ; MacCiardi, Fabio ; Nieminen, Markku S. ; Ohlsson, Claes ; Palmer, Lyle J. ; Ridker, Paul ; Stumvoll, Micheal ; Beckmann, Jacques ; Boeing, Heiner ; Boerwinkle, Eeric ; BOmsma, Dorret I. ; Caulfield, Mark J. ; Chanock, Stephan J. ; Collins, Francis ; Cupples, L. Adrienne ; Smith, George Davey ; Eerdmann, Jeanette ; Frogue, Philippe ; Grönberg, Henrik ; Gyllensten, Ulf ; Hall, Per ; Hansen, Torben ; Harris, Tamara B. ; Hattersley, Andrew T. ; Hayes, Richard B. ; Heinrich, Joachim ; Hu, Frank B. ; Hveem, Kristian ; Illig, Thomas ; Jarvelin, Marjo Riitta ; Kaprio, Jaakko ; Karpe, Fredrik ; Khaw, Kay Ttee ; Kiemeney, Lambertus A. ; Krude, Heiko ; Laakso, Markku ; Lawlor, Debbie A. ; Metspalu, Andres ; Munroe, Patricia B. ; Ouwehand, Willem H. ; Pedersen, Oluf ; Penninx, Brenda W. ; Peters, Annette ; Pramstaller, Peter P. ; Quertermous, Thomas ; Reinehr, Thomas ; Rissanen, Aila ; Rudan, Igor ; Samani, Nilesh J. ; Schwarz, Peter E H ; Shuldiner, Alan R. ; Spector, Timothy D. ; Tuomilehto, Jaakko ; Uda, Manuela ; Uitterlinden, André ; Valle, Timo ; Wabitsch, Martin ; Waeber, Gérard ; Wareham, Nicholas J. ; Watkins, Hugh ; Wilson, James F. ; Wright, Alan F. ; Zillikens, M. Ccarola ; ChatterjE, Nilanjan ; McCarroll, Steven A. ; Purcell, Shaun ; Schadt, Eric ; Visscher, Peter ; Assimes, Themistocles L. ; Borecki, Ingrid B. ; Deloukas, Panos ; Fox, Caroline S. ; Groop, Leif C. ; Haritunians, Talin ; Hunter, David J. ; Kaplan, Robert C. ; Mohlke, Karen ; O'ConneL, Jeffrey R. ; Peltonen, Leena ; SchleSinger, David ; P Strachan, David P. ; Van Duijn, Cornelia ; Wichmann, H. Erich ; Frayling, Timothy M. ; Thorsteinsdottir, Unnur ; Abecasis, Gonçalo R. ; Barroso, Inês ; Boehnke, Michael ; StefanSon, Kari ; North, Kari E. ; McArthy, Mark I. ; Hirschhorn, Joel N. ; IngelSon, Erik ; Loos, Ruth J F. / Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. In: Nature Genetics. 2010 ; Vol. 42, No. 11. pp. 937-948.
@article{516d8e729d3046c69e7158157894e98c,
title = "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index",
abstract = "Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.",
author = "Speliotes, {Elizabeth K.} and Willer, {Cristen J.} and Berndt, {Sonja I.} and Monda, {Keri L.} and Gudmar Thorleifsson and Jackson, {Anne U.} and Allen, {Hana Lango} and Lindgren, {Cecilia M.} and Jian'An Luan and Reedik M{\"a}gi and Randall, {Joshua C.} and Sailaja Vedantam and Winkler, {Thomas W.} and Lu Qi and Tsegaselassie Workalemahu and Iris Heid and Valgerdur Steinthorsdottir and Heather Stringham and Weedon, {Michael N.} and Eeleanor Wheeler and Wood, {Andrew R.} and Teresa Ferreira and Weyant, {Robert J.} and Segr{\`e}, {Ayellet V.} and Karol Eestrada and Liming Liang and James Nemesh and Park, {Ju Hyun} and Stefan Gustafsson and Kilpel{\"a}inen, {Tuomas O.} and Jian Yang and Nabila Bouatia-Naji and T{\~o}nu Eesko and Feitosa, {Mary F.} and Zolt{\'a}n Kutalik and Massimo Mangino and Soumya Raychaudhuri and Andre Scherag and Smith, {Albert Vernon} and Ryan Welch and Zhao, {Jing Hua} and Aben, {Katja K.} and Absher, {Devin M.} and Najaf Amin and Dixon, {Anna L.} and Eeva Fisher and Nicole Glazer and Goddard, {Michael E.} and Nancy Heard-Costa and Volker Hoesel and Hottenga, {Jouke Jan} and {\AA}sa Johansson and Toby Johnson and Shamika Ketkar and Claudia Lamina and Shengxu Li and Moffatt, {Miriam F.} and Myers, {Richard H.} and Narisu Narisu and Perry, {John R B} and Peters, {Marjolein J.} and Micheal Preuss and Samuli Ripatti and Fernando Rivadeneira and Camilla Sandholt and Scott, {Laura J.} and Timpson, {Nicholas J.} and Tyrer, {Jonathan P.} and {Van Wingerden}, Sophie and Richard Watanabe and White, {Charles C.} and Fredrik Wiklund and Christina Barlassina and Chasman, {Daniel I.} and Cooper, {Matthew N.} and Jansson, {John Olov} and Lawrence, {Robert W.} and Niina Pellikka and Inga Prokopenko and Jianxin Shi and Eelisabeth Thiering and Helene Alavere and Alibrandi, {Maria T S} and Peter Almgren and Alice Arnold and Thor Aspelund and Atwood, {Larry D.} and Beverley Balkau and Balmforth, {Anthony J.} and Bennett, {Amanda J.} and Yoav Ben-Shlomo and Richard Bergman and Sven Bergmann and Heike Biebermann and Blakemore, {Alexandra I F} and Tanja Boes and Lori Bonnycastle and Bornstein, {Stefan R.} and Brown, {Morris J.} and Buchanan, {Thomas A.} and Fabio Busonero and Harry Campbell and Cappuccio, {Francesco P.} and Christine Cavalcanti-Proen{\cc}a and {Ida Chen}, {Yii Dder} and Chen, {Chih Mei} and Peter Chines and Robert Clarke and Lachlan Coin and John Connell and Ian Day and {Den Heijer}, Martin and Jubao Duan and Shah Eebrahim and Paul Eelliott and Roberto Eelosua and Gudny Eeiriksdottir and Eerdos, {Micheal R.} and Eeriksson, {Johan G.} and Facheris, {Maurizio F.} and Felix, {Stephan B.} and Pamela Fischer-Posovszky and Folsom, {Aaron R.} and Nele Friedrich and Freimer, {Nelson B.} and Mao Fu and Stefan Gaget and Gejman, {Pablo V.} and Geus, {Eeco J.} and Christian Gieger and Gjesing, {Anette P.} and Anuj Goel and Philippe Goyette and Harald Grallert and J{\"u}rgen Gr{\"a}{\ss}ler and Danielle Greenawalt and Groves, {Christopher J.} and Vilmundur Gudnason and Candace Guiducci and Hartikainen, {Anna Lliisa} and Neelam Hassanali and Alistair Hall and Aki Havulinna and Caroline Hayward and Andrew Heath and Christian Hengstenberg and Hicks, {Andrew A.} and Anke Hinney and Albert Hofman and Georg Homuth and Jennie Hui and Wilmar Igl and Carlos Iribarren and Bo Isomaa and Jacobs, {Kevin B.} and Ivonne Jarick and Eelizabeth Jewell and Ulrich John and Torben J{\o}rgensen and Pekka Jousilahti and Antti Jula and Marika Kaakinen and Eeero Kajantie and Lee Kaplan and Sekar Kathiresan and Johannes Kettunen and Leena Kinnunen and Joshua Knowles and Ivana Kolcic and K{\"o}nig, {Inke R.} and Seppo Koskinen and Peter Kovacs and Johanna Kusisto and Peter Kraft and Kirsti Kval{\o}y and Jaana Laitinen and Olivier Lantieri and Chiara Lanzani and Launer, {Lenore J.} and Cecile Lecoeur and Terho Lehtim{\"a}ki and Guillaume Lettre and Jianjun Liu and Lokki, {Marja Lissa} and Mattias Lorentzon and Robert Luben and Barbara Ludwig and Magic and Paolo Manunta and Diana Marek and Michel Marre and Martin, {Nicholas G.} and Wendy McArdle and Anne McCarthy and Barbara McKnight and Thomas Meitinger and Olle Melander and David Meyre and Kristian Midthjell and Grant Montgomery and Morken, {Mario A.} and Morris, {Andrew P.} and Rosanda Mulic and Julius Ngwa and Mari Nelis and Neville, {Matt J.} and Nyholt, {Dale R.} and O'Ddonnell, {Christopher J.} and Stephen O'Rahilly and Ken Ong and Ben Ostra and Guillaume Par{\'e} and Alex Parker and Markus Perola and Irene Pichler and Pietil{\"a}inen, {Kirsi H.} and Platou, {Carl P.} and Ozren Polasek and Anneli Pouta and Suzanne Rafelt and Olli Raitakari and Nigel Rayner and Martin Ridderstr{\aa}le and Winfried Rief and Aimo Ruokonen and Robertson, {Neil R.} and Peter Rzehak and Veikko Salomaa and Sanders, {Alan R.} and Manjinder Sandhu and Serena Sanna and Jouko Saramies and Savolainen, {Markku J.} and Susann Scherag and Sabine Schipf and Stefan Schreiber and Heribert Schunkert and Kaisa Silander and Juha Sinisalo and Siscovick, {David S.} and Smit, {Jan H.} and Nicole Soranzo and Ulla Sovio and Jonathan Stephens and Ida Surakka and Swift, {Amy J.} and Tammesoo, {Mari Lliis} and Tardif, {Jean Claude} and Maris Teder-Laving and Tanya Teslovich and Thompson, {John R.} and Brian Thomson and Anke T{\"o}njes and Tiinamaija Tuomi and {Van Meurs}, {Joyce B J} and {Van OMen}, {Gert Jan} and Vincent Vatin and Jorma Viikari and Sophie Visvikis-Siest and Veronique Vitart and Vogel, {Carla I.} and Voight, {Benjamin F.} and Lindsay Waite and Henri Wallaschofski and Bragi Walters and Elisabeth Widen and Susanna Wiegand and Wild, {Sarah H.} and Gonneke Willemsen and Witte, {Deniel R.} and Jacqueline Witteman and Jianfeng Xu and Qunyuan Zhang and Lina Zgaga and Andreas Ziegler and Paavo Zitting and Beilby, {John P.} and FarOqi, {I. Ssadaf} and Johannes Hebebrand and Huikuri, {Heikki V.} and Alan James and Mika K{\"a}h{\"o}nen and Levinson, {Douglas F.} and Fabio MacCiardi and Nieminen, {Markku S.} and Claes Ohlsson and Palmer, {Lyle J.} and Paul Ridker and Micheal Stumvoll and Jacques Beckmann and Heiner Boeing and Eeric Boerwinkle and BOmsma, {Dorret I.} and Caulfield, {Mark J.} and Chanock, {Stephan J.} and Francis Collins and Cupples, {L. Adrienne} and Smith, {George Davey} and Jeanette Eerdmann and Philippe Frogue and Henrik Gr{\"o}nberg and Ulf Gyllensten and Per Hall and Torben Hansen and Harris, {Tamara B.} and Hattersley, {Andrew T.} and Hayes, {Richard B.} and Joachim Heinrich and Hu, {Frank B.} and Kristian Hveem and Thomas Illig and Jarvelin, {Marjo Riitta} and Jaakko Kaprio and Fredrik Karpe and Khaw, {Kay Ttee} and Kiemeney, {Lambertus A.} and Heiko Krude and Markku Laakso and Lawlor, {Debbie A.} and Andres Metspalu and Munroe, {Patricia B.} and Ouwehand, {Willem H.} and Oluf Pedersen and Penninx, {Brenda W.} and Annette Peters and Pramstaller, {Peter P.} and Thomas Quertermous and Thomas Reinehr and Aila Rissanen and Igor Rudan and Samani, {Nilesh J.} and Schwarz, {Peter E H} and Shuldiner, {Alan R.} and Spector, {Timothy D.} and Jaakko Tuomilehto and Manuela Uda and Andr{\'e} Uitterlinden and Timo Valle and Martin Wabitsch and G{\'e}rard Waeber and Wareham, {Nicholas J.} and Hugh Watkins and Wilson, {James F.} and Wright, {Alan F.} and Zillikens, {M. Ccarola} and Nilanjan ChatterjE and McCarroll, {Steven A.} and Shaun Purcell and Eric Schadt and Peter Visscher and Assimes, {Themistocles L.} and Borecki, {Ingrid B.} and Panos Deloukas and Fox, {Caroline S.} and Groop, {Leif C.} and Talin Haritunians and Hunter, {David J.} and Kaplan, {Robert C.} and Karen Mohlke and O'ConneL, {Jeffrey R.} and Leena Peltonen and David SchleSinger and {P Strachan}, {David P.} and {Van Duijn}, Cornelia and Wichmann, {H. Erich} and Frayling, {Timothy M.} and Unnur Thorsteinsdottir and Abecasis, {Gon{\cc}alo R.} and In{\^e}s Barroso and Michael Boehnke and Kari StefanSon and North, {Kari E.} and McArthy, {Mark I.} and Hirschhorn, {Joel N.} and Erik IngelSon and Loos, {Ruth J F}",
year = "2010",
month = "11",
doi = "10.1038/ng.686",
language = "English (US)",
volume = "42",
pages = "937--948",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

AU - Speliotes, Elizabeth K.

AU - Willer, Cristen J.

AU - Berndt, Sonja I.

AU - Monda, Keri L.

AU - Thorleifsson, Gudmar

AU - Jackson, Anne U.

AU - Allen, Hana Lango

AU - Lindgren, Cecilia M.

AU - Luan, Jian'An

AU - Mägi, Reedik

AU - Randall, Joshua C.

AU - Vedantam, Sailaja

AU - Winkler, Thomas W.

AU - Qi, Lu

AU - Workalemahu, Tsegaselassie

AU - Heid, Iris

AU - Steinthorsdottir, Valgerdur

AU - Stringham, Heather

AU - Weedon, Michael N.

AU - Wheeler, Eeleanor

AU - Wood, Andrew R.

AU - Ferreira, Teresa

AU - Weyant, Robert J.

AU - Segrè, Ayellet V.

AU - Eestrada, Karol

AU - Liang, Liming

AU - Nemesh, James

AU - Park, Ju Hyun

AU - Gustafsson, Stefan

AU - Kilpeläinen, Tuomas O.

AU - Yang, Jian

AU - Bouatia-Naji, Nabila

AU - Eesko, Tõnu

AU - Feitosa, Mary F.

AU - Kutalik, Zoltán

AU - Mangino, Massimo

AU - Raychaudhuri, Soumya

AU - Scherag, Andre

AU - Smith, Albert Vernon

AU - Welch, Ryan

AU - Zhao, Jing Hua

AU - Aben, Katja K.

AU - Absher, Devin M.

AU - Amin, Najaf

AU - Dixon, Anna L.

AU - Fisher, Eeva

AU - Glazer, Nicole

AU - Goddard, Michael E.

AU - Heard-Costa, Nancy

AU - Hoesel, Volker

AU - Hottenga, Jouke Jan

AU - Johansson, Åsa

AU - Johnson, Toby

AU - Ketkar, Shamika

AU - Lamina, Claudia

AU - Li, Shengxu

AU - Moffatt, Miriam F.

AU - Myers, Richard H.

AU - Narisu, Narisu

AU - Perry, John R B

AU - Peters, Marjolein J.

AU - Preuss, Micheal

AU - Ripatti, Samuli

AU - Rivadeneira, Fernando

AU - Sandholt, Camilla

AU - Scott, Laura J.

AU - Timpson, Nicholas J.

AU - Tyrer, Jonathan P.

AU - Van Wingerden, Sophie

AU - Watanabe, Richard

AU - White, Charles C.

AU - Wiklund, Fredrik

AU - Barlassina, Christina

AU - Chasman, Daniel I.

AU - Cooper, Matthew N.

AU - Jansson, John Olov

AU - Lawrence, Robert W.

AU - Pellikka, Niina

AU - Prokopenko, Inga

AU - Shi, Jianxin

AU - Thiering, Eelisabeth

AU - Alavere, Helene

AU - Alibrandi, Maria T S

AU - Almgren, Peter

AU - Arnold, Alice

AU - Aspelund, Thor

AU - Atwood, Larry D.

AU - Balkau, Beverley

AU - Balmforth, Anthony J.

AU - Bennett, Amanda J.

AU - Ben-Shlomo, Yoav

AU - Bergman, Richard

AU - Bergmann, Sven

AU - Biebermann, Heike

AU - Blakemore, Alexandra I F

AU - Boes, Tanja

AU - Bonnycastle, Lori

AU - Bornstein, Stefan R.

AU - Brown, Morris J.

AU - Buchanan, Thomas A.

AU - Busonero, Fabio

AU - Campbell, Harry

AU - Cappuccio, Francesco P.

AU - Cavalcanti-Proença, Christine

AU - Ida Chen, Yii Dder

AU - Chen, Chih Mei

AU - Chines, Peter

AU - Clarke, Robert

AU - Coin, Lachlan

AU - Connell, John

AU - Day, Ian

AU - Den Heijer, Martin

AU - Duan, Jubao

AU - Eebrahim, Shah

AU - Eelliott, Paul

AU - Eelosua, Roberto

AU - Eeiriksdottir, Gudny

AU - Eerdos, Micheal R.

AU - Eeriksson, Johan G.

AU - Facheris, Maurizio F.

AU - Felix, Stephan B.

AU - Fischer-Posovszky, Pamela

AU - Folsom, Aaron R.

AU - Friedrich, Nele

AU - Freimer, Nelson B.

AU - Fu, Mao

AU - Gaget, Stefan

AU - Gejman, Pablo V.

AU - Geus, Eeco J.

AU - Gieger, Christian

AU - Gjesing, Anette P.

AU - Goel, Anuj

AU - Goyette, Philippe

AU - Grallert, Harald

AU - Gräßler, Jürgen

AU - Greenawalt, Danielle

AU - Groves, Christopher J.

AU - Gudnason, Vilmundur

AU - Guiducci, Candace

AU - Hartikainen, Anna Lliisa

AU - Hassanali, Neelam

AU - Hall, Alistair

AU - Havulinna, Aki

AU - Hayward, Caroline

AU - Heath, Andrew

AU - Hengstenberg, Christian

AU - Hicks, Andrew A.

AU - Hinney, Anke

AU - Hofman, Albert

AU - Homuth, Georg

AU - Hui, Jennie

AU - Igl, Wilmar

AU - Iribarren, Carlos

AU - Isomaa, Bo

AU - Jacobs, Kevin B.

AU - Jarick, Ivonne

AU - Jewell, Eelizabeth

AU - John, Ulrich

AU - Jørgensen, Torben

AU - Jousilahti, Pekka

AU - Jula, Antti

AU - Kaakinen, Marika

AU - Kajantie, Eeero

AU - Kaplan, Lee

AU - Kathiresan, Sekar

AU - Kettunen, Johannes

AU - Kinnunen, Leena

AU - Knowles, Joshua

AU - Kolcic, Ivana

AU - König, Inke R.

AU - Koskinen, Seppo

AU - Kovacs, Peter

AU - Kusisto, Johanna

AU - Kraft, Peter

AU - Kvaløy, Kirsti

AU - Laitinen, Jaana

AU - Lantieri, Olivier

AU - Lanzani, Chiara

AU - Launer, Lenore J.

AU - Lecoeur, Cecile

AU - Lehtimäki, Terho

AU - Lettre, Guillaume

AU - Liu, Jianjun

AU - Lokki, Marja Lissa

AU - Lorentzon, Mattias

AU - Luben, Robert

AU - Ludwig, Barbara

AU - Magic,

AU - Manunta, Paolo

AU - Marek, Diana

AU - Marre, Michel

AU - Martin, Nicholas G.

AU - McArdle, Wendy

AU - McCarthy, Anne

AU - McKnight, Barbara

AU - Meitinger, Thomas

AU - Melander, Olle

AU - Meyre, David

AU - Midthjell, Kristian

AU - Montgomery, Grant

AU - Morken, Mario A.

AU - Morris, Andrew P.

AU - Mulic, Rosanda

AU - Ngwa, Julius

AU - Nelis, Mari

AU - Neville, Matt J.

AU - Nyholt, Dale R.

AU - O'Ddonnell, Christopher J.

AU - O'Rahilly, Stephen

AU - Ong, Ken

AU - Ostra, Ben

AU - Paré, Guillaume

AU - Parker, Alex

AU - Perola, Markus

AU - Pichler, Irene

AU - Pietiläinen, Kirsi H.

AU - Platou, Carl P.

AU - Polasek, Ozren

AU - Pouta, Anneli

AU - Rafelt, Suzanne

AU - Raitakari, Olli

AU - Rayner, Nigel

AU - Ridderstråle, Martin

AU - Rief, Winfried

AU - Ruokonen, Aimo

AU - Robertson, Neil R.

AU - Rzehak, Peter

AU - Salomaa, Veikko

AU - Sanders, Alan R.

AU - Sandhu, Manjinder

AU - Sanna, Serena

AU - Saramies, Jouko

AU - Savolainen, Markku J.

AU - Scherag, Susann

AU - Schipf, Sabine

AU - Schreiber, Stefan

AU - Schunkert, Heribert

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PY - 2010/11

Y1 - 2010/11

N2 - Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.

AB - Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.

UR - http://www.scopus.com/inward/record.url?scp=78049337953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049337953&partnerID=8YFLogxK

U2 - 10.1038/ng.686

DO - 10.1038/ng.686

M3 - Article

VL - 42

SP - 937

EP - 948

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -