Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

Helmuth H G van Es, A. Bout, J. Liu, L. Anderson, A. M V Duncan, P. Bosma, R. Oude Elferink, P. L M Jansen, Jayanta Roy-Chowdhury, E. Schurr

Research output: Contribution to journalArticle

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Abstract

UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1 A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.

Original languageEnglish (US)
Pages (from-to)114-116
Number of pages3
JournalCytogenetic and Genome Research
Volume63
Issue number2
DOIs
StatePublished - 1993

Fingerprint

Glucuronosyltransferase
Protein Isoforms
Chromosomes
bilirubin glucuronoside glucuronosyltransferase
Genes
Glucuronic Acid
Alternative Splicing
Human Genome
Multigene Family
Bilirubin
In Situ Hybridization
Complementary DNA
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

van Es, H. H. G., Bout, A., Liu, J., Anderson, L., Duncan, A. M. V., Bosma, P., ... Schurr, E. (1993). Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. Cytogenetic and Genome Research, 63(2), 114-116. https://doi.org/10.1159/000133513

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. / van Es, Helmuth H G; Bout, A.; Liu, J.; Anderson, L.; Duncan, A. M V; Bosma, P.; Oude Elferink, R.; Jansen, P. L M; Roy-Chowdhury, Jayanta; Schurr, E.

In: Cytogenetic and Genome Research, Vol. 63, No. 2, 1993, p. 114-116.

Research output: Contribution to journalArticle

van Es, HHG, Bout, A, Liu, J, Anderson, L, Duncan, AMV, Bosma, P, Oude Elferink, R, Jansen, PLM, Roy-Chowdhury, J & Schurr, E 1993, 'Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37', Cytogenetic and Genome Research, vol. 63, no. 2, pp. 114-116. https://doi.org/10.1159/000133513
van Es, Helmuth H G ; Bout, A. ; Liu, J. ; Anderson, L. ; Duncan, A. M V ; Bosma, P. ; Oude Elferink, R. ; Jansen, P. L M ; Roy-Chowdhury, Jayanta ; Schurr, E. / Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. In: Cytogenetic and Genome Research. 1993 ; Vol. 63, No. 2. pp. 114-116.
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