Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

Helmuth H.G. van Es, A. Bout, J. Liu, L. Anderson, A. M.V. Duncan, P. Bosma, R. Oude Elferink, P. L.M. Jansen, J. Roy Chowdhury, E. Schurr

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1 A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.

Original languageEnglish (US)
Pages (from-to)114-116
Number of pages3
JournalCytogenetic and Genome Research
Issue number2
StatePublished - 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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