Assessment of Thyroid Function

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The thyroid hormones Thyroxine (T4) and Triiodothyronine (T3) can be measured directly in serum by radioimmunoassay. Most serum T4 and T3 circulates bound to specific serum-binding proteins but, the small unbound fraction, free T4, correlates best with hormonal activity. The free T4 concentration can be measured directly and also can be estimated from the T3 resin uptake as the free T4 index (FT4-1). In hypothyroidism, T4 and FT4-1 are decreased and when the disorder results from thyroid gland failure, serum TSH will be elevated as well. Indeed, an increase in serum TSH is the most sensitive index of thyroid gland failure. Hyperthyroidism is associated with increased serum T4, T3, and free T4. About 5% of patients have a selective increase in T3 secretion: T3 thyrotoxicosis. In these, serum T4 is normal but serum T3 is elevated. An absent TSH response to thyrotropin-releasing hormone (TRH) is the hallmark of hyperthyroidism due to suppression of anterior pituitary TSH secretion.

Original languageEnglish (US)
Pages (from-to)476-478
Number of pages3
JournalOphthalmology
Volume88
Issue number6
DOIs
StatePublished - Jan 1 1981

Keywords

  • free T
  • hyperthyroidism
  • hypothyroidism
  • serum thyrotropin (TSH)
  • thyroid
  • thyrotropin-releas ing hormone (TRH)
  • thyroxine (T)
  • triidothyronine (T)

ASJC Scopus subject areas

  • Ophthalmology

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