Assessment of thyroid function

Research output: Contribution to journalArticle

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Abstract

The thyroid hormones Thyroxine (T4) and Triiodothyronine (T3) can be measured directly in serum by radioimmunoassay. Most serum T4 and T3 circulates bound to specific serum-binding proteins but the small unbound fraction, free T4, correlates best with hormonal activity. The free T4 concentration can be measured directly and also can be estimated from the T3-resin uptake as the free T4 index (FT4-1). In hypothyroidism, T4 and FT4-1 are decreased and when the disorder results from thyroid gland failure, serum TSH will be elevated as well. Indeed, an increase in serum TSH is the most sensitive index of thyroid gland failure. Hyperthyroidism is associated with increased serum T4, T3, and free T4. About 5% of patients have a selective increase in T3 secretion, T3 thyrotoxicosis. In these, serum T4 is normal but serum T3 is elevated. An absent TSH response to thyrotropin-releasing hormone (TRH) is the hallmark of hyperthyroidism due to suppression of anterior pituitary TSH secretion.

Original languageEnglish (US)
Pages (from-to)476-478
Number of pages3
JournalOphthalmology
Volume88
Issue number6
StatePublished - 1981

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Thyroid Gland
Serum
Hyperthyroidism
Thyroxine
Thyrotoxicosis
Thyrotropin-Releasing Hormone
Triiodothyronine
Hypothyroidism
Radioimmunoassay
Blood Proteins
Carrier Proteins

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Assessment of thyroid function. / Surks, Martin I.

In: Ophthalmology, Vol. 88, No. 6, 1981, p. 476-478.

Research output: Contribution to journalArticle

Surks, MI 1981, 'Assessment of thyroid function', Ophthalmology, vol. 88, no. 6, pp. 476-478.
Surks, Martin I. / Assessment of thyroid function. In: Ophthalmology. 1981 ; Vol. 88, No. 6. pp. 476-478.
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