Assessment of the association of copd and asthma with in-hospital mortality in patients with covid-19. A systematic review, meta-analysis, and meta-regression analysis

Felix M. Reyes, Manuel Hache-Marliere, Dimitris Karamanis, Cesar G. Berto, Rodolfo Estrada, Matthew Langston, George Ntaios, Perminder Gulani, Chirag D. Shah, Leonidas Palaiodimos

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Together, chronic obstructive pulmonary disease (COPD) and asthma account for the most common non-infectious respiratory pathologies. Conflicting preliminary studies have shown varied effect for COPD and asthma as prognostic factors for mortality in coronavirus disease 2019 (COVID-19). The aim of this study was to explore the association of COPD and asthma with in-hospital mortality in patients with COVID-19 by systematically reviewing and synthesizing with a meta-analysis the available observational studies. MEDLINE, Scopus, and medRxiv databases were reviewed. A random-effects model meta-analysis was used, and I-square was utilized to assess for heterogeneity. In-hospital mortality was defined as the primary endpoint. Sensitivity and meta-regression analyses were performed. Thirty studies with 21,309 patients were included in this meta-analysis (1465 with COPD and 633 with asthma). Hospitalized COVID-19 patients with COPD had higher risk of death compared to those without COPD (OR: 2.29; 95% CI: 1.79–2.93; I2 59.6%). No significant difference in in-hospital mortality was seen in patients with and without asthma (OR: 0.87; 95% CI: 0.68–1.10; I2 0.0%). The likelihood of death was significantly higher in patients with COPD that were hospitalized with COVID-19 compared to patients without COPD. Further studies are needed to assess whether this association is independent or not. No significant difference was demonstrated in COVID-19-related mortality between patients with and without asthma.

Original languageEnglish (US)
Article number2087
JournalJournal of Clinical Medicine
Volume10
Issue number10
DOIs
StatePublished - May 2021

Keywords

  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • COVID-19
  • Meta-analysis
  • Mortality

ASJC Scopus subject areas

  • Medicine(all)

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