Assessment of salivary function change in nasopharyngeal carcinoma treated by parotid-sparing radiotherapy

Wen Shan Liu, Hsiang-Chi Kuo, Jin Ching Lin, Mao Chang Su, Jong Kang Lee, Ming Jen Chou, Ming Chih Chou, Huei Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE: The purpose of this study was to evaluate function of major salivary glands, subjective xerostomia, and correlation between subjective and objective xerostomia scoring after precision-oriented radiotherapy for nasopharyngeal carcinoma. MATERIALS AND METHODS: From 2000 to 2002, 34 patients with histologically proven non-metastatic nasopharyngeal carcinoma received definitive therapy by parotid-sparing radiotherapy, which included intensity-modulated radiotherapy (33 patients > 60 Gy), 3D-conformal radiotherapy, and brachytherapy boost. Salivary function was assessed by sialoscintigraphy pre-irradiation and post-irradiation at 1, 6, 12, and 18 months. The salivary stimulated secretion ratio (SSR) was used to evaluate function of submandibular and parotid glands. Subjective and objective xerostomia was monitored by the LENT/SOMA system. RESULTS: The median dose to parotid gland was 34.6 Gy (interquartile range, 32.9-36.5 Gy). The median dose to submandibular gland was 60.5 Gy (interquartile range, 58.1-61.5 Gy). Parotid-gland post-irradiation median SSR at 1 (0.01, P = 0.000) and 6 (0.08, P = 0.002) months showed significant reduction compared with pre-irradiation data (0.30). After 12 months, parotid-gland median SSR (12 months, 0.22, P = 0.734; 18 months, 0.16, P = 0.885) lost significance compared with pre-irradiation data. Submandibular-gland postirradiation median SSR at 1 (P= 0.000), 6 (P= 0.000), 12 (P = 0.000), and 18 (P = 0.000) months all showed significant reduction compared with pre-irradiation data. There were significant correlations between LENT/SOMA subjective and objective xerostomia scores at 6 months (r = 0.657, P = 0.000), 12 months (r = 0.480, P = 0.013), and 18 months (r = 0.591, P= 0.002). CONCLUSIONS: With parotid-sparing radiotherapy for nasopharyngeal carcinoma, gland function can recover significantly 12 months after radiotherapy. There were significant rank-order correlations between LENT/SOMA subjective and objective (analytic) grading scores at 6 to 18 months' follow-up.

Original languageEnglish (US)
Pages (from-to)494-500
Number of pages7
JournalCancer Journal
Volume12
Issue number6
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

Xerostomia
Parotid Gland
Submandibular Gland
Radiotherapy
Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Brachytherapy
Salivary Glands
Nasopharyngeal carcinoma
Therapeutics

Keywords

  • Intensity modulated radiotherapy
  • Nasopharyngeal carcinoma
  • Parotid gland
  • Sialoscintigraphy
  • Submandibular gland
  • Xerostomia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Assessment of salivary function change in nasopharyngeal carcinoma treated by parotid-sparing radiotherapy. / Liu, Wen Shan; Kuo, Hsiang-Chi; Lin, Jin Ching; Su, Mao Chang; Lee, Jong Kang; Chou, Ming Jen; Chou, Ming Chih; Lee, Huei.

In: Cancer Journal, Vol. 12, No. 6, 11.2006, p. 494-500.

Research output: Contribution to journalArticle

Liu, Wen Shan ; Kuo, Hsiang-Chi ; Lin, Jin Ching ; Su, Mao Chang ; Lee, Jong Kang ; Chou, Ming Jen ; Chou, Ming Chih ; Lee, Huei. / Assessment of salivary function change in nasopharyngeal carcinoma treated by parotid-sparing radiotherapy. In: Cancer Journal. 2006 ; Vol. 12, No. 6. pp. 494-500.
@article{36251eff594246c68b40ce791127ea99,
title = "Assessment of salivary function change in nasopharyngeal carcinoma treated by parotid-sparing radiotherapy",
abstract = "PURPOSE: The purpose of this study was to evaluate function of major salivary glands, subjective xerostomia, and correlation between subjective and objective xerostomia scoring after precision-oriented radiotherapy for nasopharyngeal carcinoma. MATERIALS AND METHODS: From 2000 to 2002, 34 patients with histologically proven non-metastatic nasopharyngeal carcinoma received definitive therapy by parotid-sparing radiotherapy, which included intensity-modulated radiotherapy (33 patients > 60 Gy), 3D-conformal radiotherapy, and brachytherapy boost. Salivary function was assessed by sialoscintigraphy pre-irradiation and post-irradiation at 1, 6, 12, and 18 months. The salivary stimulated secretion ratio (SSR) was used to evaluate function of submandibular and parotid glands. Subjective and objective xerostomia was monitored by the LENT/SOMA system. RESULTS: The median dose to parotid gland was 34.6 Gy (interquartile range, 32.9-36.5 Gy). The median dose to submandibular gland was 60.5 Gy (interquartile range, 58.1-61.5 Gy). Parotid-gland post-irradiation median SSR at 1 (0.01, P = 0.000) and 6 (0.08, P = 0.002) months showed significant reduction compared with pre-irradiation data (0.30). After 12 months, parotid-gland median SSR (12 months, 0.22, P = 0.734; 18 months, 0.16, P = 0.885) lost significance compared with pre-irradiation data. Submandibular-gland postirradiation median SSR at 1 (P= 0.000), 6 (P= 0.000), 12 (P = 0.000), and 18 (P = 0.000) months all showed significant reduction compared with pre-irradiation data. There were significant correlations between LENT/SOMA subjective and objective xerostomia scores at 6 months (r = 0.657, P = 0.000), 12 months (r = 0.480, P = 0.013), and 18 months (r = 0.591, P= 0.002). CONCLUSIONS: With parotid-sparing radiotherapy for nasopharyngeal carcinoma, gland function can recover significantly 12 months after radiotherapy. There were significant rank-order correlations between LENT/SOMA subjective and objective (analytic) grading scores at 6 to 18 months' follow-up.",
keywords = "Intensity modulated radiotherapy, Nasopharyngeal carcinoma, Parotid gland, Sialoscintigraphy, Submandibular gland, Xerostomia",
author = "Liu, {Wen Shan} and Hsiang-Chi Kuo and Lin, {Jin Ching} and Su, {Mao Chang} and Lee, {Jong Kang} and Chou, {Ming Jen} and Chou, {Ming Chih} and Huei Lee",
year = "2006",
month = "11",
doi = "10.1097/00130404-200611000-00009",
language = "English (US)",
volume = "12",
pages = "494--500",
journal = "Cancer journal (Sudbury, Mass.)",
issn = "1528-9117",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Assessment of salivary function change in nasopharyngeal carcinoma treated by parotid-sparing radiotherapy

AU - Liu, Wen Shan

AU - Kuo, Hsiang-Chi

AU - Lin, Jin Ching

AU - Su, Mao Chang

AU - Lee, Jong Kang

AU - Chou, Ming Jen

AU - Chou, Ming Chih

AU - Lee, Huei

PY - 2006/11

Y1 - 2006/11

N2 - PURPOSE: The purpose of this study was to evaluate function of major salivary glands, subjective xerostomia, and correlation between subjective and objective xerostomia scoring after precision-oriented radiotherapy for nasopharyngeal carcinoma. MATERIALS AND METHODS: From 2000 to 2002, 34 patients with histologically proven non-metastatic nasopharyngeal carcinoma received definitive therapy by parotid-sparing radiotherapy, which included intensity-modulated radiotherapy (33 patients > 60 Gy), 3D-conformal radiotherapy, and brachytherapy boost. Salivary function was assessed by sialoscintigraphy pre-irradiation and post-irradiation at 1, 6, 12, and 18 months. The salivary stimulated secretion ratio (SSR) was used to evaluate function of submandibular and parotid glands. Subjective and objective xerostomia was monitored by the LENT/SOMA system. RESULTS: The median dose to parotid gland was 34.6 Gy (interquartile range, 32.9-36.5 Gy). The median dose to submandibular gland was 60.5 Gy (interquartile range, 58.1-61.5 Gy). Parotid-gland post-irradiation median SSR at 1 (0.01, P = 0.000) and 6 (0.08, P = 0.002) months showed significant reduction compared with pre-irradiation data (0.30). After 12 months, parotid-gland median SSR (12 months, 0.22, P = 0.734; 18 months, 0.16, P = 0.885) lost significance compared with pre-irradiation data. Submandibular-gland postirradiation median SSR at 1 (P= 0.000), 6 (P= 0.000), 12 (P = 0.000), and 18 (P = 0.000) months all showed significant reduction compared with pre-irradiation data. There were significant correlations between LENT/SOMA subjective and objective xerostomia scores at 6 months (r = 0.657, P = 0.000), 12 months (r = 0.480, P = 0.013), and 18 months (r = 0.591, P= 0.002). CONCLUSIONS: With parotid-sparing radiotherapy for nasopharyngeal carcinoma, gland function can recover significantly 12 months after radiotherapy. There were significant rank-order correlations between LENT/SOMA subjective and objective (analytic) grading scores at 6 to 18 months' follow-up.

AB - PURPOSE: The purpose of this study was to evaluate function of major salivary glands, subjective xerostomia, and correlation between subjective and objective xerostomia scoring after precision-oriented radiotherapy for nasopharyngeal carcinoma. MATERIALS AND METHODS: From 2000 to 2002, 34 patients with histologically proven non-metastatic nasopharyngeal carcinoma received definitive therapy by parotid-sparing radiotherapy, which included intensity-modulated radiotherapy (33 patients > 60 Gy), 3D-conformal radiotherapy, and brachytherapy boost. Salivary function was assessed by sialoscintigraphy pre-irradiation and post-irradiation at 1, 6, 12, and 18 months. The salivary stimulated secretion ratio (SSR) was used to evaluate function of submandibular and parotid glands. Subjective and objective xerostomia was monitored by the LENT/SOMA system. RESULTS: The median dose to parotid gland was 34.6 Gy (interquartile range, 32.9-36.5 Gy). The median dose to submandibular gland was 60.5 Gy (interquartile range, 58.1-61.5 Gy). Parotid-gland post-irradiation median SSR at 1 (0.01, P = 0.000) and 6 (0.08, P = 0.002) months showed significant reduction compared with pre-irradiation data (0.30). After 12 months, parotid-gland median SSR (12 months, 0.22, P = 0.734; 18 months, 0.16, P = 0.885) lost significance compared with pre-irradiation data. Submandibular-gland postirradiation median SSR at 1 (P= 0.000), 6 (P= 0.000), 12 (P = 0.000), and 18 (P = 0.000) months all showed significant reduction compared with pre-irradiation data. There were significant correlations between LENT/SOMA subjective and objective xerostomia scores at 6 months (r = 0.657, P = 0.000), 12 months (r = 0.480, P = 0.013), and 18 months (r = 0.591, P= 0.002). CONCLUSIONS: With parotid-sparing radiotherapy for nasopharyngeal carcinoma, gland function can recover significantly 12 months after radiotherapy. There were significant rank-order correlations between LENT/SOMA subjective and objective (analytic) grading scores at 6 to 18 months' follow-up.

KW - Intensity modulated radiotherapy

KW - Nasopharyngeal carcinoma

KW - Parotid gland

KW - Sialoscintigraphy

KW - Submandibular gland

KW - Xerostomia

UR - http://www.scopus.com/inward/record.url?scp=33845875453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845875453&partnerID=8YFLogxK

U2 - 10.1097/00130404-200611000-00009

DO - 10.1097/00130404-200611000-00009

M3 - Article

VL - 12

SP - 494

EP - 500

JO - Cancer journal (Sudbury, Mass.)

JF - Cancer journal (Sudbury, Mass.)

SN - 1528-9117

IS - 6

ER -