Assessment of multiple task activation and reproducibility in patients with benign and low-grade neoplasms

Rachel D. McKinsey, C. H. Moritz, M. E. Meyerand, W. A. Tomé

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Twenty-four patients with proven benign and low-grade brain neoplasms each performed two iterations of four fMRI paradigms: language (word generation), primary and associa tion auditory (text listening), upper limb fine motor control (alternating-limb bilateral finger tapping), and primary visual perception (reversing checkerboard). Activation clusters with varying thresholds were generated for each scan and used to calculate reproducibility parameters: Difference in the Center of Mass (COM) location, Rsize, and R overlap. The average difference in the COM, Rsize, and Roverlap values ranged from 1.70 ± 0.53 mm -10.60 ± 3.21 mm, 0.6 ± 0.04-0.90 ± 0.05 and 0.23 ± 0.12 -1 ± 0.16 respectively for all tasks. These values are within the range of, or higher than, previously published reports on fMRI test-retest precision. FMRI is indicated to be a noninvasive tool with acceptable reproducibility measures for assessing the localizations of multiple language and sensorimotor functions in patients scheduled for radiotherapy treatment.

Original languageEnglish (US)
Pages (from-to)319-326
Number of pages8
JournalTechnology in Cancer Research and Treatment
Issue number4
StatePublished - Aug 2010
Externally publishedYes


  • Benign and low-grade brain neoplasms
  • Blood oxygen level dependent
  • Reproducibility
  • fMRI

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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