Assessment of lead stores in children: Validation of an 8-hour CaNa2EDTA provocative test

Morri E. Markowitz, John F. Rosen

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Twenty-four-hour CaNa2EDTA provocative tests for the assessment of lead stores were successfully performed in 36 asymptomatic children with mild to moderate undue lead absorption (blood lead concentration ≤69 μg/dl and erythrocyte protoporphyrin ≥50 μg/dl). By comparing lead excretion during the first 8 hours with that excreted during the entire 24-hour test, new criteria have been developed to define positive outcomes. We suggest that the excretion of ≥200 μg lead per 8 hours or a ratio of urinary lead (μg)/CaNa2EDTA administered (mg)≥0.70 after a single intramuscular injection of CaNa2EDTA (500 mg/m2) can identify those children who will respond to chelation treatment with lead diuresis.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalThe Journal of Pediatrics
Issue number3
StatePublished - Mar 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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