TY - JOUR
T1 - Assessment of diastolic function by tissue Doppler echocardiography
T2 - Comparison with standard transmitral and pulmonary venous flow
AU - Farias, Carlos A.
AU - Rodriguez, Leonardo
AU - Garcia, Mario J.
AU - Sun, Jing P.
AU - Klein, Allan L.
AU - Thomas, James D.
PY - 1999/8
Y1 - 1999/8
N2 - The objective of this study was to determine the utility of Doppler tissue echocardiography in the evaluation of diastolic filling and in discriminating between normal subjects and those with various stages of diastolic dysfunction. We measured myocardial velocities in 51 patients with various stages of diastolic dysfunction and in 27 normal volunteers. The discriminating power of each of the standard Doppler indexes of left ventricular filling, pulmonary venous flow, and myocardial velocities was determined with the use of Spearman rank correlation and analysis of variance F statistics. Early diastolic myocardial velocity (E(m)) was higher in normal subjects (16.0 ± 3.8 cm/s) than in patients with either delayed relaxation (n = 15, 7.5 ± 2.2 cm/s), pseudonormal filling (n = 26, 7.6 ± 2.3 cm/s), or restrictive filling (n = 10, 7.4 ± 2.4 cm/s, P < .0001). E(m) was the best single discriminator between control subjects and patients with diastolic dysfunction (P = .7, F = 64.5). Myocardial velocities assessed by Doppler tissue echocardiography are useful in differentiating patients with normal from those with abnormal diastolic function. Myocardial velocity remains reduced even in those stages of diastolic dysfunction characterized by increased preload compensation.
AB - The objective of this study was to determine the utility of Doppler tissue echocardiography in the evaluation of diastolic filling and in discriminating between normal subjects and those with various stages of diastolic dysfunction. We measured myocardial velocities in 51 patients with various stages of diastolic dysfunction and in 27 normal volunteers. The discriminating power of each of the standard Doppler indexes of left ventricular filling, pulmonary venous flow, and myocardial velocities was determined with the use of Spearman rank correlation and analysis of variance F statistics. Early diastolic myocardial velocity (E(m)) was higher in normal subjects (16.0 ± 3.8 cm/s) than in patients with either delayed relaxation (n = 15, 7.5 ± 2.2 cm/s), pseudonormal filling (n = 26, 7.6 ± 2.3 cm/s), or restrictive filling (n = 10, 7.4 ± 2.4 cm/s, P < .0001). E(m) was the best single discriminator between control subjects and patients with diastolic dysfunction (P = .7, F = 64.5). Myocardial velocities assessed by Doppler tissue echocardiography are useful in differentiating patients with normal from those with abnormal diastolic function. Myocardial velocity remains reduced even in those stages of diastolic dysfunction characterized by increased preload compensation.
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U2 - 10.1053/je.1999.v12.a99249
DO - 10.1053/je.1999.v12.a99249
M3 - Article
C2 - 10441216
AN - SCOPUS:0032811178
SN - 0894-7317
VL - 12
SP - 609
EP - 617
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 8
ER -