Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers

Ines N. Nishimoto, Javier Pintos, Nicholas F. Schlecht, Humberto Torloni, André L. Carvalho, Luiz P. Kowalski, Eduardo L. Franco

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Most of the evidence identifying determinants of UADT cancer risk comes from hospital-based case-control studies. However, such studies are thought to be influenced by selection bias given the extent of association of tobacco smoking and alcohol drinking with other diseases in the general population. We assessed the extent of selection bias due to inclusion of controls with tobacco or alcohol related diseases in a hospital-based case-control study of upper aero-digestive tract (UADT) cancers in Brazil. Methods. Risk factor information was obtained from 784 cases and 1568 non-cancer controls. Causes of hospitalization for controls were scored according to their likelihood of association with tobacco and alcohol. Odds ratios (OR) were calculated by conditional logistic regression with and without exclusion of controls with tobacco or alcohol related diseases. Results. The OR for smoking slightly increased after exclusion of controls with tobacco-related diseases, from 15.3 (95% confidence interval [CI]: 9.7, 24.2) among heaviest smokers (pack-years > 91) to 18.6 (95%CI: 11.4, 30.2). The OR for alcohol consumption remained unchanged after exclusion of controls with alcohol related diseases. Associations of low magnitude for some dietary variables (citric fruits, carotene-rich foods, spicy foods, maté tea) and wood stove use were not appreciably affected by the exclusion of controls. Conclusion. The bias introduced by controls with tobacco and alcohol related diseases is small, when these exposures are investigated as determinants, and almost negligible when considered as confounders of the association between other factors and UADT cancers.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalJournal of Cancer Epidemiology and Prevention
Volume7
Issue number3
StatePublished - 2002
Externally publishedYes

Fingerprint

Selection Bias
Gastrointestinal Tract
Case-Control Studies
Tobacco
Alcohols
Neoplasms
Odds Ratio
Alcohol Drinking
Smoking
Confidence Intervals
Food
Tea
Carotenoids
Brazil
Fruit
Hospitalization
Logistic Models
Population

Keywords

  • Case-control studies
  • Epidemiological methods
  • Head and neck neoplasms
  • Risk factors
  • Selection bias

ASJC Scopus subject areas

  • Epidemiology
  • Cancer Research

Cite this

Nishimoto, I. N., Pintos, J., Schlecht, N. F., Torloni, H., Carvalho, A. L., Kowalski, L. P., & Franco, E. L. (2002). Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers. Journal of Cancer Epidemiology and Prevention, 7(3), 131-141.

Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers. / Nishimoto, Ines N.; Pintos, Javier; Schlecht, Nicholas F.; Torloni, Humberto; Carvalho, André L.; Kowalski, Luiz P.; Franco, Eduardo L.

In: Journal of Cancer Epidemiology and Prevention, Vol. 7, No. 3, 2002, p. 131-141.

Research output: Contribution to journalArticle

Nishimoto, IN, Pintos, J, Schlecht, NF, Torloni, H, Carvalho, AL, Kowalski, LP & Franco, EL 2002, 'Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers', Journal of Cancer Epidemiology and Prevention, vol. 7, no. 3, pp. 131-141.
Nishimoto, Ines N. ; Pintos, Javier ; Schlecht, Nicholas F. ; Torloni, Humberto ; Carvalho, André L. ; Kowalski, Luiz P. ; Franco, Eduardo L. / Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers. In: Journal of Cancer Epidemiology and Prevention. 2002 ; Vol. 7, No. 3. pp. 131-141.
@article{90dc3b2789864db9b5884428ea817e7f,
title = "Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers",
abstract = "Background. Most of the evidence identifying determinants of UADT cancer risk comes from hospital-based case-control studies. However, such studies are thought to be influenced by selection bias given the extent of association of tobacco smoking and alcohol drinking with other diseases in the general population. We assessed the extent of selection bias due to inclusion of controls with tobacco or alcohol related diseases in a hospital-based case-control study of upper aero-digestive tract (UADT) cancers in Brazil. Methods. Risk factor information was obtained from 784 cases and 1568 non-cancer controls. Causes of hospitalization for controls were scored according to their likelihood of association with tobacco and alcohol. Odds ratios (OR) were calculated by conditional logistic regression with and without exclusion of controls with tobacco or alcohol related diseases. Results. The OR for smoking slightly increased after exclusion of controls with tobacco-related diseases, from 15.3 (95{\%} confidence interval [CI]: 9.7, 24.2) among heaviest smokers (pack-years > 91) to 18.6 (95{\%}CI: 11.4, 30.2). The OR for alcohol consumption remained unchanged after exclusion of controls with alcohol related diseases. Associations of low magnitude for some dietary variables (citric fruits, carotene-rich foods, spicy foods, mat{\'e} tea) and wood stove use were not appreciably affected by the exclusion of controls. Conclusion. The bias introduced by controls with tobacco and alcohol related diseases is small, when these exposures are investigated as determinants, and almost negligible when considered as confounders of the association between other factors and UADT cancers.",
keywords = "Case-control studies, Epidemiological methods, Head and neck neoplasms, Risk factors, Selection bias",
author = "Nishimoto, {Ines N.} and Javier Pintos and Schlecht, {Nicholas F.} and Humberto Torloni and Carvalho, {Andr{\'e} L.} and Kowalski, {Luiz P.} and Franco, {Eduardo L.}",
year = "2002",
language = "English (US)",
volume = "7",
pages = "131--141",
journal = "Journal of Cancer Epidemiology and Prevention",
issn = "1476-6647",
publisher = "Isis Medical Media Ltd.",
number = "3",

}

TY - JOUR

T1 - Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers

AU - Nishimoto, Ines N.

AU - Pintos, Javier

AU - Schlecht, Nicholas F.

AU - Torloni, Humberto

AU - Carvalho, André L.

AU - Kowalski, Luiz P.

AU - Franco, Eduardo L.

PY - 2002

Y1 - 2002

N2 - Background. Most of the evidence identifying determinants of UADT cancer risk comes from hospital-based case-control studies. However, such studies are thought to be influenced by selection bias given the extent of association of tobacco smoking and alcohol drinking with other diseases in the general population. We assessed the extent of selection bias due to inclusion of controls with tobacco or alcohol related diseases in a hospital-based case-control study of upper aero-digestive tract (UADT) cancers in Brazil. Methods. Risk factor information was obtained from 784 cases and 1568 non-cancer controls. Causes of hospitalization for controls were scored according to their likelihood of association with tobacco and alcohol. Odds ratios (OR) were calculated by conditional logistic regression with and without exclusion of controls with tobacco or alcohol related diseases. Results. The OR for smoking slightly increased after exclusion of controls with tobacco-related diseases, from 15.3 (95% confidence interval [CI]: 9.7, 24.2) among heaviest smokers (pack-years > 91) to 18.6 (95%CI: 11.4, 30.2). The OR for alcohol consumption remained unchanged after exclusion of controls with alcohol related diseases. Associations of low magnitude for some dietary variables (citric fruits, carotene-rich foods, spicy foods, maté tea) and wood stove use were not appreciably affected by the exclusion of controls. Conclusion. The bias introduced by controls with tobacco and alcohol related diseases is small, when these exposures are investigated as determinants, and almost negligible when considered as confounders of the association between other factors and UADT cancers.

AB - Background. Most of the evidence identifying determinants of UADT cancer risk comes from hospital-based case-control studies. However, such studies are thought to be influenced by selection bias given the extent of association of tobacco smoking and alcohol drinking with other diseases in the general population. We assessed the extent of selection bias due to inclusion of controls with tobacco or alcohol related diseases in a hospital-based case-control study of upper aero-digestive tract (UADT) cancers in Brazil. Methods. Risk factor information was obtained from 784 cases and 1568 non-cancer controls. Causes of hospitalization for controls were scored according to their likelihood of association with tobacco and alcohol. Odds ratios (OR) were calculated by conditional logistic regression with and without exclusion of controls with tobacco or alcohol related diseases. Results. The OR for smoking slightly increased after exclusion of controls with tobacco-related diseases, from 15.3 (95% confidence interval [CI]: 9.7, 24.2) among heaviest smokers (pack-years > 91) to 18.6 (95%CI: 11.4, 30.2). The OR for alcohol consumption remained unchanged after exclusion of controls with alcohol related diseases. Associations of low magnitude for some dietary variables (citric fruits, carotene-rich foods, spicy foods, maté tea) and wood stove use were not appreciably affected by the exclusion of controls. Conclusion. The bias introduced by controls with tobacco and alcohol related diseases is small, when these exposures are investigated as determinants, and almost negligible when considered as confounders of the association between other factors and UADT cancers.

KW - Case-control studies

KW - Epidemiological methods

KW - Head and neck neoplasms

KW - Risk factors

KW - Selection bias

UR - http://www.scopus.com/inward/record.url?scp=0037987788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037987788&partnerID=8YFLogxK

M3 - Article

C2 - 12665212

AN - SCOPUS:0037987788

VL - 7

SP - 131

EP - 141

JO - Journal of Cancer Epidemiology and Prevention

JF - Journal of Cancer Epidemiology and Prevention

SN - 1476-6647

IS - 3

ER -