Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.

John J. Foxe, Kristen P. Morie, Peter J. Laud, Matthew J. Rowson, Eveline A. de Bruin, Simon P. Kelly

Research output: Contribution to journalArticle

Abstract

Caffeine and L-theanine, both naturally occurring in tea, affect the ability to make rapid phasic deployments of attention to locations in space as reflected in behavioural performance and alpha-band oscillatory brain activity (8-14 Hz). However, surprisingly little is known about how these compounds affect an aspect of attention that has been more popularly associated with tea, namely vigilant attention: the ability to maintain focus on monotonous tasks over protracted time-periods. Twenty-seven participants performed the Sustained Attention to Response Task (SART) over a two-hour session on each of four days, on which they were administered caffeine (50 mg), theanine (100 mg), the combination, or placebo in a double-blind, randomized, cross-over fashion. Concurrently, we recorded oscillatory brain activity through high-density electroencephalography (EEG). We asked whether either compound alone, or both in combination, would affect performance of the task in terms of reduced error rates over time, and whether changes in alpha-band activity would show a relationship to such changes in performance. When treated with placebo, participants showed a rise in error rates, a pattern that is commonly observed with increasing time-on-task, whereas after caffeine and theanine ingestion, error rates were significantly reduced. The combined treatment did not confer any additional benefits over either compound alone, suggesting that the individual compounds may confer maximal benefits at the dosages employed. Alpha-band oscillatory activity was significantly reduced on ingestion of caffeine, particularly in the first hour. This effect was not changed by addition of theanine in the combined treatment. Theanine alone did not affect alpha-band activity.

Original languageEnglish (US)
Pages (from-to)2320-2327
Number of pages8
JournalNeuropharmacology
Volume62
Issue number7
StatePublished - Jun 2012
Externally publishedYes

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Caffeine
Maintenance
Aptitude
Tea
Eating
Placebos
Brain
Task Performance and Analysis
Electroencephalography
theanine
Therapeutics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Foxe, J. J., Morie, K. P., Laud, P. J., Rowson, M. J., de Bruin, E. A., & Kelly, S. P. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology, 62(7), 2320-2327.

Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. / Foxe, John J.; Morie, Kristen P.; Laud, Peter J.; Rowson, Matthew J.; de Bruin, Eveline A.; Kelly, Simon P.

In: Neuropharmacology, Vol. 62, No. 7, 06.2012, p. 2320-2327.

Research output: Contribution to journalArticle

Foxe, JJ, Morie, KP, Laud, PJ, Rowson, MJ, de Bruin, EA & Kelly, SP 2012, 'Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.', Neuropharmacology, vol. 62, no. 7, pp. 2320-2327.
Foxe JJ, Morie KP, Laud PJ, Rowson MJ, de Bruin EA, Kelly SP. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology. 2012 Jun;62(7):2320-2327.
Foxe, John J. ; Morie, Kristen P. ; Laud, Peter J. ; Rowson, Matthew J. ; de Bruin, Eveline A. ; Kelly, Simon P. / Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. In: Neuropharmacology. 2012 ; Vol. 62, No. 7. pp. 2320-2327.
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