Assessing renal function after partial nephrectomy using renal nuclear scintigraphy and estimated glomerular filtration rate

Alexander I. Sankin, John P. Sfakianos, Jeffrey Schiff, Daniel Sjoberg, Jonathan A. Coleman

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Abstract

Objective: To create a model intended to more accurately characterize renal function alteration after partial nephrectomy using a combination of renal scintigraphy and estimated glomerular filtration rate (eGFR). Methods: Thirty-two partial nephrectomy patients from a single center with preoperative and postoperative renal scans were reviewed. Renal scan data were used to calculate proportional eGFR in the involved kidney as a product of the percentage function of the operated kidney and total eGFR. Linear regression models were created to describe endpoints (postoperative eGFR, involved kidney percent function, proportional eGFR) as functions of clinical variables associated with kidney damage. Results: For the ipsilateral kidney, mean preoperative percent function and eGFR were 50% (SD, 4.8) and 31 mL/min/m 2 (SD, 3.4), respectively; postoperative percent function and involved kidney eGFR were 44% (SD, 9.0) and 27 mL/min/m 2 (SD, 9.0), respectively. Decreased postoperative proportional eGFR was significantly associated with increased clamp time and tumor size in univariate linear regression models. Clamp time was associated with total eGFR, where tumor size was not. Additionally, clamp time and tumor size explain more of the variation in proportional eGFR (R 2 = 0.39 and R 2 = 0.17, respectively), compared to percent effort and total eGFR. Conclusion: Proportional eGFR has a stronger association with putative factors of renal dysfunction after partial nephrectomy, including clamp time and tumor size, compared to total eGFR, indicating it may be a more sensitive marker of renal function after partial nephrectomy.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalUrology
Volume80
Issue number2
DOIs
StatePublished - Aug 2012
Externally publishedYes

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Nephrectomy
Glomerular Filtration Rate
Radionuclide Imaging
Kidney
Linear Models
Neoplasms

ASJC Scopus subject areas

  • Urology

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Assessing renal function after partial nephrectomy using renal nuclear scintigraphy and estimated glomerular filtration rate. / Sankin, Alexander I.; Sfakianos, John P.; Schiff, Jeffrey; Sjoberg, Daniel; Coleman, Jonathan A.

In: Urology, Vol. 80, No. 2, 08.2012, p. 343-346.

Research output: Contribution to journalArticle

Sankin, Alexander I. ; Sfakianos, John P. ; Schiff, Jeffrey ; Sjoberg, Daniel ; Coleman, Jonathan A. / Assessing renal function after partial nephrectomy using renal nuclear scintigraphy and estimated glomerular filtration rate. In: Urology. 2012 ; Vol. 80, No. 2. pp. 343-346.
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