Assessing excess lifetime risk for disease after radiation exposure

Xiaonan (Nan) Xue, R. E. Shore

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this paper, we define the excess lifetime risk for a disease due to radiation exposure, and we evaluate the excess lifetime risk for an exposed group with the same age and with a mixture of ages. We propose two methods to estimate the excess lifetime risk: the standard maximum likelihood approach and a Monte-Carlo approach. Both approaches allow us to construct confidence intervals for the excess lifetime risk and perform hypothesis testing to compare two excess risks. The maximum likelihood approach is straightforward and computationally simple; however, it may not provide good approximations when the normality assumption is violated. The Monte-Carlo approach is always reliable, but often involves heavier computations and additional programming. These two approaches are illustrated and discussed based on a pooled analysis of five cohorts exposed to external radiation and followed up for subsequent thyroid cancer incidence.

Original languageEnglish (US)
Pages (from-to)462-469
Number of pages8
JournalHealth Physics
Volume80
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

radiation exposure
radiation dosage
Radiation
life (durability)
Maximum likelihood
normality
programming
Thyroid Neoplasms
hypothesis testing
confidence
Cohort Studies
confidence interval
incidence
cancer
Radiation Exposure
Confidence Intervals
intervals
Incidence
Testing
radiation

Keywords

  • Exposure, radiation
  • Health effects
  • Radiation effects
  • Risk analysis

ASJC Scopus subject areas

  • Environmental Science (miscellaneous)
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Physics and Astronomy (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Assessing excess lifetime risk for disease after radiation exposure. / Xue, Xiaonan (Nan); Shore, R. E.

In: Health Physics, Vol. 80, No. 5, 2001, p. 462-469.

Research output: Contribution to journalArticle

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