Assessing Cardiac Metabolism

Heinrich Taegtmeyer, Martin E. Young, Gary D. Lopaschuk, E. Dale Abel, Henri Brunengraber, Victor Darley-Usmar, Christine Des Rosiers, Robert Gerszten, Jan F. Glatz, Julian L. Griffin, Robert J. Gropler, Hermann Georg Holzhuetter, Jorge Kizer, E. Douglas Lewandowski, Craig R. Malloy, Stefan Neubauer, Linda R. Peterson, Michael A. Portman, Fabio A. Recchia, Jennifer E. Van EykThomas J. Wang

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.

Original languageEnglish (US)
Pages (from-to)1659-1701
Number of pages43
JournalCirculation Research
Volume118
Issue number10
DOIs
StatePublished - May 13 2016

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Keywords

  • AHA Scientific Statements
  • metabolic pathways
  • metabolism, cardiac
  • molecular biology
  • radionuclide imaging
  • systems biology

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Taegtmeyer, H., Young, M. E., Lopaschuk, G. D., Abel, E. D., Brunengraber, H., Darley-Usmar, V., Des Rosiers, C., Gerszten, R., Glatz, J. F., Griffin, J. L., Gropler, R. J., Holzhuetter, H. G., Kizer, J., Lewandowski, E. D., Malloy, C. R., Neubauer, S., Peterson, L. R., Portman, M. A., Recchia, F. A., ... Wang, T. J. (2016). Assessing Cardiac Metabolism. Circulation Research, 118(10), 1659-1701. https://doi.org/10.1161/RES.0000000000000097