Assessing anxious features in depressed outpatients

Shawn M. Mcclintock, Mustafa M. Husain, Ira H. Bernstein, Stephen R. Wisniewski, Madhukar H. Trivedi, David Morris, Jonathan E. Alpert, Diane Warden, James F. Luther, Susan G. Kornstein, Melanie M. Biggs, Maurizio Fava, A. John Rush

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Both the 17-item Hamilton Rating Scale for Depression (HRSD 17) and 30-item Inventory of Depressive Symptomatology - Clinician-rated (IDS-C 30) contain a subscale that assesses anxious symptoms. We used classical test theory and item response theory methods to assess and compare the psychometric properties of the two anxiety subscales (HRSD ANX and IDS-C ANX) in a large sample (N=3453) of outpatients with non-psychotic major depressive disorder in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Approximately 48% of evaluable participants had at least one concurrent anxiety disorder by the self-report Psychiatric Diagnostic Screening Questionnaire (PDSQ). The HRSD ANX and IDS-C ANX were highly correlated (r=0.75) and both had moderate internal consistency given their limited number of items (HRSD ANX Cronbach's alpha=0.48; IDS-C ANX Cronbach's alpha=0.58). The optimal threshold for ascribing the presence/absence of anxious features was found at a total score of eight or nine for the HRSD ANX and seven or eight for the IDS-C ANX. It would seem beneficial to delete item 17 (loss of insight) from the HRSD ANX as it negatively correlated with the scale's total score. Both the HRSD ANX and IDS-C ANX subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes.

Original languageEnglish (US)
JournalInternational Journal of Methods in Psychiatric Research
Volume20
Issue number4
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Psychometrics
Outpatients
Depression
Major Depressive Disorder
Anxiety Disorders
Self Report
Psychiatry
Anxiety
Equipment and Supplies
Research
Therapeutics
IDS 30
Surveys and Questionnaires

Keywords

  • Anxiety
  • Depression
  • Measurement-based care
  • Rating scales
  • STAR*D

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Mcclintock, S. M., Husain, M. M., Bernstein, I. H., Wisniewski, S. R., Trivedi, M. H., Morris, D., ... Rush, A. J. (2011). Assessing anxious features in depressed outpatients. International Journal of Methods in Psychiatric Research, 20(4). https://doi.org/10.1002/mpr.353

Assessing anxious features in depressed outpatients. / Mcclintock, Shawn M.; Husain, Mustafa M.; Bernstein, Ira H.; Wisniewski, Stephen R.; Trivedi, Madhukar H.; Morris, David; Alpert, Jonathan E.; Warden, Diane; Luther, James F.; Kornstein, Susan G.; Biggs, Melanie M.; Fava, Maurizio; Rush, A. John.

In: International Journal of Methods in Psychiatric Research, Vol. 20, No. 4, 12.2011.

Research output: Contribution to journalArticle

Mcclintock, SM, Husain, MM, Bernstein, IH, Wisniewski, SR, Trivedi, MH, Morris, D, Alpert, JE, Warden, D, Luther, JF, Kornstein, SG, Biggs, MM, Fava, M & Rush, AJ 2011, 'Assessing anxious features in depressed outpatients', International Journal of Methods in Psychiatric Research, vol. 20, no. 4. https://doi.org/10.1002/mpr.353
Mcclintock SM, Husain MM, Bernstein IH, Wisniewski SR, Trivedi MH, Morris D et al. Assessing anxious features in depressed outpatients. International Journal of Methods in Psychiatric Research. 2011 Dec;20(4). https://doi.org/10.1002/mpr.353
Mcclintock, Shawn M. ; Husain, Mustafa M. ; Bernstein, Ira H. ; Wisniewski, Stephen R. ; Trivedi, Madhukar H. ; Morris, David ; Alpert, Jonathan E. ; Warden, Diane ; Luther, James F. ; Kornstein, Susan G. ; Biggs, Melanie M. ; Fava, Maurizio ; Rush, A. John. / Assessing anxious features in depressed outpatients. In: International Journal of Methods in Psychiatric Research. 2011 ; Vol. 20, No. 4.
@article{66d2fac2f941465fb479e0da9f9af5cb,
title = "Assessing anxious features in depressed outpatients",
abstract = "Both the 17-item Hamilton Rating Scale for Depression (HRSD 17) and 30-item Inventory of Depressive Symptomatology - Clinician-rated (IDS-C 30) contain a subscale that assesses anxious symptoms. We used classical test theory and item response theory methods to assess and compare the psychometric properties of the two anxiety subscales (HRSD ANX and IDS-C ANX) in a large sample (N=3453) of outpatients with non-psychotic major depressive disorder in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Approximately 48{\%} of evaluable participants had at least one concurrent anxiety disorder by the self-report Psychiatric Diagnostic Screening Questionnaire (PDSQ). The HRSD ANX and IDS-C ANX were highly correlated (r=0.75) and both had moderate internal consistency given their limited number of items (HRSD ANX Cronbach's alpha=0.48; IDS-C ANX Cronbach's alpha=0.58). The optimal threshold for ascribing the presence/absence of anxious features was found at a total score of eight or nine for the HRSD ANX and seven or eight for the IDS-C ANX. It would seem beneficial to delete item 17 (loss of insight) from the HRSD ANX as it negatively correlated with the scale's total score. Both the HRSD ANX and IDS-C ANX subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes.",
keywords = "Anxiety, Depression, Measurement-based care, Rating scales, STAR*D",
author = "Mcclintock, {Shawn M.} and Husain, {Mustafa M.} and Bernstein, {Ira H.} and Wisniewski, {Stephen R.} and Trivedi, {Madhukar H.} and David Morris and Alpert, {Jonathan E.} and Diane Warden and Luther, {James F.} and Kornstein, {Susan G.} and Biggs, {Melanie M.} and Maurizio Fava and Rush, {A. John}",
year = "2011",
month = "12",
doi = "10.1002/mpr.353",
language = "English (US)",
volume = "20",
journal = "International Journal of Methods in Psychiatric Research",
issn = "1049-8931",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

TY - JOUR

T1 - Assessing anxious features in depressed outpatients

AU - Mcclintock, Shawn M.

AU - Husain, Mustafa M.

AU - Bernstein, Ira H.

AU - Wisniewski, Stephen R.

AU - Trivedi, Madhukar H.

AU - Morris, David

AU - Alpert, Jonathan E.

AU - Warden, Diane

AU - Luther, James F.

AU - Kornstein, Susan G.

AU - Biggs, Melanie M.

AU - Fava, Maurizio

AU - Rush, A. John

PY - 2011/12

Y1 - 2011/12

N2 - Both the 17-item Hamilton Rating Scale for Depression (HRSD 17) and 30-item Inventory of Depressive Symptomatology - Clinician-rated (IDS-C 30) contain a subscale that assesses anxious symptoms. We used classical test theory and item response theory methods to assess and compare the psychometric properties of the two anxiety subscales (HRSD ANX and IDS-C ANX) in a large sample (N=3453) of outpatients with non-psychotic major depressive disorder in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Approximately 48% of evaluable participants had at least one concurrent anxiety disorder by the self-report Psychiatric Diagnostic Screening Questionnaire (PDSQ). The HRSD ANX and IDS-C ANX were highly correlated (r=0.75) and both had moderate internal consistency given their limited number of items (HRSD ANX Cronbach's alpha=0.48; IDS-C ANX Cronbach's alpha=0.58). The optimal threshold for ascribing the presence/absence of anxious features was found at a total score of eight or nine for the HRSD ANX and seven or eight for the IDS-C ANX. It would seem beneficial to delete item 17 (loss of insight) from the HRSD ANX as it negatively correlated with the scale's total score. Both the HRSD ANX and IDS-C ANX subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes.

AB - Both the 17-item Hamilton Rating Scale for Depression (HRSD 17) and 30-item Inventory of Depressive Symptomatology - Clinician-rated (IDS-C 30) contain a subscale that assesses anxious symptoms. We used classical test theory and item response theory methods to assess and compare the psychometric properties of the two anxiety subscales (HRSD ANX and IDS-C ANX) in a large sample (N=3453) of outpatients with non-psychotic major depressive disorder in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Approximately 48% of evaluable participants had at least one concurrent anxiety disorder by the self-report Psychiatric Diagnostic Screening Questionnaire (PDSQ). The HRSD ANX and IDS-C ANX were highly correlated (r=0.75) and both had moderate internal consistency given their limited number of items (HRSD ANX Cronbach's alpha=0.48; IDS-C ANX Cronbach's alpha=0.58). The optimal threshold for ascribing the presence/absence of anxious features was found at a total score of eight or nine for the HRSD ANX and seven or eight for the IDS-C ANX. It would seem beneficial to delete item 17 (loss of insight) from the HRSD ANX as it negatively correlated with the scale's total score. Both the HRSD ANX and IDS-C ANX subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes.

KW - Anxiety

KW - Depression

KW - Measurement-based care

KW - Rating scales

KW - STARD

UR - http://www.scopus.com/inward/record.url?scp=82155166262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82155166262&partnerID=8YFLogxK

U2 - 10.1002/mpr.353

DO - 10.1002/mpr.353

M3 - Article

VL - 20

JO - International Journal of Methods in Psychiatric Research

JF - International Journal of Methods in Psychiatric Research

SN - 1049-8931

IS - 4

ER -