Aspiration occurence during chemoradiation for head and neck cancer

Nam P. Nguyen, Herbert J. Smith, Suresh Dutta, Alan Alfieri, Debra North, Phuc D. Nguyen, L. E E Howard, Tomas Martinez, Claire Lemanski, Adir Ludin, Ly M. Nguyen, Sabah Sallah

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.

Original languageEnglish (US)
Pages (from-to)1669-1672
Number of pages4
JournalAnticancer Research
Volume27
Issue number3 B
StatePublished - May 2007

Fingerprint

Head and Neck Neoplasms
Deglutition
Barium
Thorax
X-Rays
Aspiration Pneumonia
Mucositis
Neutropenia
Patient Care
Radiation
Anti-Bacterial Agents

Keywords

  • Aspiration
  • Chemoradiation
  • Head and neck cancer
  • Pneumonia
  • Swallow

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nguyen, N. P., Smith, H. J., Dutta, S., Alfieri, A., North, D., Nguyen, P. D., ... Sallah, S. (2007). Aspiration occurence during chemoradiation for head and neck cancer. Anticancer Research, 27(3 B), 1669-1672.

Aspiration occurence during chemoradiation for head and neck cancer. / Nguyen, Nam P.; Smith, Herbert J.; Dutta, Suresh; Alfieri, Alan; North, Debra; Nguyen, Phuc D.; Howard, L. E E; Martinez, Tomas; Lemanski, Claire; Ludin, Adir; Nguyen, Ly M.; Sallah, Sabah.

In: Anticancer Research, Vol. 27, No. 3 B, 05.2007, p. 1669-1672.

Research output: Contribution to journalArticle

Nguyen, NP, Smith, HJ, Dutta, S, Alfieri, A, North, D, Nguyen, PD, Howard, LEE, Martinez, T, Lemanski, C, Ludin, A, Nguyen, LM & Sallah, S 2007, 'Aspiration occurence during chemoradiation for head and neck cancer', Anticancer Research, vol. 27, no. 3 B, pp. 1669-1672.
Nguyen NP, Smith HJ, Dutta S, Alfieri A, North D, Nguyen PD et al. Aspiration occurence during chemoradiation for head and neck cancer. Anticancer Research. 2007 May;27(3 B):1669-1672.
Nguyen, Nam P. ; Smith, Herbert J. ; Dutta, Suresh ; Alfieri, Alan ; North, Debra ; Nguyen, Phuc D. ; Howard, L. E E ; Martinez, Tomas ; Lemanski, Claire ; Ludin, Adir ; Nguyen, Ly M. ; Sallah, Sabah. / Aspiration occurence during chemoradiation for head and neck cancer. In: Anticancer Research. 2007 ; Vol. 27, No. 3 B. pp. 1669-1672.
@article{abd95c1806d04d7eac9dd90430ddaac8,
title = "Aspiration occurence during chemoradiation for head and neck cancer",
abstract = "Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13{\%}) developed aspiration during chemoradiation. Twelve patients (10{\%}) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3{\%}) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5{\%}) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.",
keywords = "Aspiration, Chemoradiation, Head and neck cancer, Pneumonia, Swallow",
author = "Nguyen, {Nam P.} and Smith, {Herbert J.} and Suresh Dutta and Alan Alfieri and Debra North and Nguyen, {Phuc D.} and Howard, {L. E E} and Tomas Martinez and Claire Lemanski and Adir Ludin and Nguyen, {Ly M.} and Sabah Sallah",
year = "2007",
month = "5",
language = "English (US)",
volume = "27",
pages = "1669--1672",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "3 B",

}

TY - JOUR

T1 - Aspiration occurence during chemoradiation for head and neck cancer

AU - Nguyen, Nam P.

AU - Smith, Herbert J.

AU - Dutta, Suresh

AU - Alfieri, Alan

AU - North, Debra

AU - Nguyen, Phuc D.

AU - Howard, L. E E

AU - Martinez, Tomas

AU - Lemanski, Claire

AU - Ludin, Adir

AU - Nguyen, Ly M.

AU - Sallah, Sabah

PY - 2007/5

Y1 - 2007/5

N2 - Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.

AB - Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.

KW - Aspiration

KW - Chemoradiation

KW - Head and neck cancer

KW - Pneumonia

KW - Swallow

UR - http://www.scopus.com/inward/record.url?scp=34249330694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249330694&partnerID=8YFLogxK

M3 - Article

C2 - 17595794

AN - SCOPUS:34249330694

VL - 27

SP - 1669

EP - 1672

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 3 B

ER -