Aspergillus sinusitis in two HIV-infected men.

A case report of two HIV-infected men diagnosed with aspergillus sinusitis is provided. Despite aggressive treatment with antifungal agents, such as amphotericin B and itraconazole, the sinusitis would not resolve. Both protease inhibitor-naive patients were treated with the same antiretroviral regimen. Only one of the patients had a dramatic drop in viral load; the other patient succumbed to neurologic deficits and respiratory failure. Many patients who are using protease inhibitors continue to have good clinical status despite rising viral loads. The availability of antiretroviral therapy has changed the outlook for opportunistic infections, such as severe intestinal cryptosporidiosis, PML, and azole-resistant oral candidiasis. The key role in recovery is successful treatment with antiretroviral therapy to enable the body to fight such infections.