TY - JOUR
T1 - Aspergillus sinusitis in patients with AIDS
T2 - Report of three cases and review
AU - Teh, Winnie
AU - Matti, Brenda S.
AU - Mertz, Gregory J.
AU - Marisiddaiah, Harish
AU - Minamoto, Grace Y.
PY - 1995/9
Y1 - 1995/9
N2 - Invasive aspergillosis is an uncommon but increasingly reported complication of AIDS. Sinusitis, usually bacterial in etiology, is frequently seen among human immunodeficiency virus (HIV)infected patients. We discuss the cases of three patients with AIDS and invasive aspergillus sinusitis seen at our institutions and those of 15 patients who are described in the literature. Seven of the 18 had brain involvement, 3 had orbital involvement, and 7 had mastoid or other bony disease. Three had evidence of concomitant invasive pulmonary aspergillosis. Of 15 patients with evaluable histories, 11 had recognized risks for invasive aspergillosis; 6 had previous sinusitis, otitis, or polyposis; and 11 had prior conditions indicative of advanced HIV-related disease. Despite aggressive surgical intervention and systemic antifungal therapy, nearly all patients died as a result of aspergillosis.
AB - Invasive aspergillosis is an uncommon but increasingly reported complication of AIDS. Sinusitis, usually bacterial in etiology, is frequently seen among human immunodeficiency virus (HIV)infected patients. We discuss the cases of three patients with AIDS and invasive aspergillus sinusitis seen at our institutions and those of 15 patients who are described in the literature. Seven of the 18 had brain involvement, 3 had orbital involvement, and 7 had mastoid or other bony disease. Three had evidence of concomitant invasive pulmonary aspergillosis. Of 15 patients with evaluable histories, 11 had recognized risks for invasive aspergillosis; 6 had previous sinusitis, otitis, or polyposis; and 11 had prior conditions indicative of advanced HIV-related disease. Despite aggressive surgical intervention and systemic antifungal therapy, nearly all patients died as a result of aspergillosis.
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U2 - 10.1093/clinids/21.3.529
DO - 10.1093/clinids/21.3.529
M3 - Article
C2 - 8527538
AN - SCOPUS:0029094284
SN - 1058-4838
VL - 21
SP - 529
EP - 535
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -