@article{f136f9e8f0b84c31b79a8d7800531fc4,
title = "Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation",
abstract = "The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, we provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, we describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have evaluated the drug combination in patients with severe infection. Finally, we describe the current state of current clinical practice as it relates to the thiamine, ascorbic acid, and hydrocortisone combination and present an overview of the randomized, placebo-controlled, multi-center Ascorbic acid, Corticosteroids, and Thiamine in Sepsis (ACTS) trial and other planned/ongoing randomized clinical trials.",
keywords = "Ascorbic acid, Corticosteroids, Metabolic resuscitation, Sepsis, Thiamine",
author = "Ari Moskowitz and Andersen, {Lars W.} and Huang, {David T.} and Berg, {Katherine M.} and Grossestreuer, {Anne V.} and Marik, {Paul E.} and Sherwin, {Robert L.} and Hou, {Peter C.} and Becker, {Lance B.} and Cocchi, {Michael N.} and Pratik Doshi and Jonathan Gong and Ayan Sen and Donnino, {Michael W.}",
note = "Funding Information: The ACTS trial is supported by a grant from the Open Philanthropy Project. Dr. Cocchi is funded by a grant from the American Heart Association (15SDG22420010). Dr. Moskowitz and Dr. Berg are supported by grants from the National Institutes of Health (K23GM128005–01 & 1K23HL128814–01, respectively). Dr. Grossestreuer is supported by a KL2/Catalyst Medical Research Investigator Training award (an appointed KL2 award) from Harvard Catalyst |The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award KL2 TR001100) Dr. Hou is supported by a grant from the National Institutes of Health (UO1HL122989–03). Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = oct,
day = "29",
doi = "10.1186/s13054-018-2217-4",
language = "English (US)",
volume = "22",
journal = "Critical Care",
issn = "1466-609X",
publisher = "Springer Science + Business Media",
number = "1",
}