Ascorbic Acid: A Putative Biochemical Marker of Irreversible Neurologic Functional Loss Following Spinal Cord Injury

Dennis D. Pietronigro, Vincent Decrescito, John J. Tomasula, Harry B. Demopoulos, Eugene S. Flamm

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The development of permanent parapelegia in spinal injured cats is accompanied by a large progressive decline in total ascorbic acid (AA) and a transient increase in oxidized (AAox) ascorbate. Since AA is involved in a variety of processes required for normal central nervous system (CNS) performance we suggested that such large ascorbate loss may contribute to derangements in spinal cord function following injury.(1) We now demonstrate that methylprednisolone (15 mg/kg) and naloxone (10 mg/kg), two treatments that preserve neurologic function in this model,(2,3) rapidly block deteriorating ascorbate status. Naloxone at 1 mg/kg, a treatment providing no therapeutic benefit, has no protective effect on ascorbate. The results strongly support the hypothesis that loss of ascorbate homeostasis reflects irreversible loss of neurologic function following spinal cord injury. Key Words: Ascorbic acid–Spinal cord injury–Neurologic function.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalCentral Nervous System Trauma
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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