Arterial wave reflection in HIV-infected and HIV-uninfected rwandan women

Jason M. Lazar, Xi Wu, Qiuhu Shi, Abel Kagame, Mardge Cohen, Agnes Binagwaho, Louis Munyakazi, Louis Salciccioli, Di Shi, Kathryn Anastos

Research output: Contribution to journalArticle

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Abstract

To assess differences in arterial wave reflection, a marker of atherosclerosis, in HIV-positive and HIV-negative Rwandan women, applanation tonometry was performed on 276 HIV+ and 67 HIV- participants. Radial artery pressure waveforms were recorded and central aortic waveforms were derived by validated transfer function. Central augmentation index (C-AI), central pulse pressure (C-PP), and peripheral augmentation index (P-AI) were measured. HIV+ participants were younger and had lower diastolic blood pressure (BP) and 41% of the HIV+ women were taking antiretroviral therapy (ART). Mean C-AI and P-AI were significantly lower in HIV-infected than in uninfected participants (20.3±12.0 vs. 25.5±12.1, p=0.002 and 74.6±18.8 vs. 83.7±20.0, p<0.001). After age matching, C-AI, C-PP, and P-AI were similar among the groups. On multivariate analysis, age, heart rate, weight, and mean arterial pressure were independently associated with C-AI (R2=0.33, p<0.0001). Among HIV-infected women, current CD4 count did not correlate with C-AI (Rho=-0.01, p=0.84), C-PP (Rho=0.09, p=0.16), or P-AI (Rho=-0.01, p=0.83). In conclusion, HIV infection was not associated with increased arterial wave reflection in women with little exposure to antiretroviral therapy and without CV risk factors. Whether long-term ART increases measures of arterial stiffness remains unknown.

Original languageEnglish (US)
Pages (from-to)877-882
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2009

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HIV
Blood Pressure
Vascular Stiffness
Radial Artery
Manometry
CD4 Lymphocyte Count
HIV Infections
Atherosclerosis
Arterial Pressure
Therapeutics
Multivariate Analysis
Heart Rate
Pressure
Weights and Measures

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Arterial wave reflection in HIV-infected and HIV-uninfected rwandan women. / Lazar, Jason M.; Wu, Xi; Shi, Qiuhu; Kagame, Abel; Cohen, Mardge; Binagwaho, Agnes; Munyakazi, Louis; Salciccioli, Louis; Shi, Di; Anastos, Kathryn.

In: AIDS Research and Human Retroviruses, Vol. 25, No. 9, 01.09.2009, p. 877-882.

Research output: Contribution to journalArticle

Lazar, JM, Wu, X, Shi, Q, Kagame, A, Cohen, M, Binagwaho, A, Munyakazi, L, Salciccioli, L, Shi, D & Anastos, K 2009, 'Arterial wave reflection in HIV-infected and HIV-uninfected rwandan women', AIDS Research and Human Retroviruses, vol. 25, no. 9, pp. 877-882. https://doi.org/10.1089/aid.2008.0269
Lazar, Jason M. ; Wu, Xi ; Shi, Qiuhu ; Kagame, Abel ; Cohen, Mardge ; Binagwaho, Agnes ; Munyakazi, Louis ; Salciccioli, Louis ; Shi, Di ; Anastos, Kathryn. / Arterial wave reflection in HIV-infected and HIV-uninfected rwandan women. In: AIDS Research and Human Retroviruses. 2009 ; Vol. 25, No. 9. pp. 877-882.
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AB - To assess differences in arterial wave reflection, a marker of atherosclerosis, in HIV-positive and HIV-negative Rwandan women, applanation tonometry was performed on 276 HIV+ and 67 HIV- participants. Radial artery pressure waveforms were recorded and central aortic waveforms were derived by validated transfer function. Central augmentation index (C-AI), central pulse pressure (C-PP), and peripheral augmentation index (P-AI) were measured. HIV+ participants were younger and had lower diastolic blood pressure (BP) and 41% of the HIV+ women were taking antiretroviral therapy (ART). Mean C-AI and P-AI were significantly lower in HIV-infected than in uninfected participants (20.3±12.0 vs. 25.5±12.1, p=0.002 and 74.6±18.8 vs. 83.7±20.0, p<0.001). After age matching, C-AI, C-PP, and P-AI were similar among the groups. On multivariate analysis, age, heart rate, weight, and mean arterial pressure were independently associated with C-AI (R2=0.33, p<0.0001). Among HIV-infected women, current CD4 count did not correlate with C-AI (Rho=-0.01, p=0.84), C-PP (Rho=0.09, p=0.16), or P-AI (Rho=-0.01, p=0.83). In conclusion, HIV infection was not associated with increased arterial wave reflection in women with little exposure to antiretroviral therapy and without CV risk factors. Whether long-term ART increases measures of arterial stiffness remains unknown.

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