Arterial wave reflection in HIV-infected and HIV-uninfected rwandan women

Jason M. Lazar, Xi Wu, Qiuhu Shi, Abel Kagame, Mardge Cohen, Agnes Binagwaho, Louis Munyakazi, Louis Salciccioli, Di Shi, Kathryn Anastos

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17 Scopus citations

Abstract

To assess differences in arterial wave reflection, a marker of atherosclerosis, in HIV-positive and HIV-negative Rwandan women, applanation tonometry was performed on 276 HIV+ and 67 HIV- participants. Radial artery pressure waveforms were recorded and central aortic waveforms were derived by validated transfer function. Central augmentation index (C-AI), central pulse pressure (C-PP), and peripheral augmentation index (P-AI) were measured. HIV+ participants were younger and had lower diastolic blood pressure (BP) and 41% of the HIV+ women were taking antiretroviral therapy (ART). Mean C-AI and P-AI were significantly lower in HIV-infected than in uninfected participants (20.3±12.0 vs. 25.5±12.1, p=0.002 and 74.6±18.8 vs. 83.7±20.0, p<0.001). After age matching, C-AI, C-PP, and P-AI were similar among the groups. On multivariate analysis, age, heart rate, weight, and mean arterial pressure were independently associated with C-AI (R2=0.33, p<0.0001). Among HIV-infected women, current CD4 count did not correlate with C-AI (Rho=-0.01, p=0.84), C-PP (Rho=0.09, p=0.16), or P-AI (Rho=-0.01, p=0.83). In conclusion, HIV infection was not associated with increased arterial wave reflection in women with little exposure to antiretroviral therapy and without CV risk factors. Whether long-term ART increases measures of arterial stiffness remains unknown.

Original languageEnglish (US)
Pages (from-to)877-882
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Lazar, J. M., Wu, X., Shi, Q., Kagame, A., Cohen, M., Binagwaho, A., Munyakazi, L., Salciccioli, L., Shi, D., & Anastos, K. (2009). Arterial wave reflection in HIV-infected and HIV-uninfected rwandan women. AIDS Research and Human Retroviruses, 25(9), 877-882. https://doi.org/10.1089/aid.2008.0269