TY - JOUR
T1 - Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure
T2 - Evidence from the Strong Heart Study
AU - Spratlen, Miranda Jones
AU - Gamble, Mary V.
AU - Grau-Perez, Maria
AU - Kuo, Chin Chi
AU - Best, Lyle G.
AU - Yracheta, Joseph
AU - Francesconi, Kevin
AU - Goessler, Walter
AU - Mossavar-Rahmani, Yasmin
AU - Hall, Meghan
AU - Umans, Jason G.
AU - Fretts, Amanda
AU - Navas-Acien, Ana
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/7/1
Y1 - 2017/7/1
N2 - B-vitamins involved in one-carbon metabolism (OCM) can affect arsenic metabolism efficiency in highly arsenic exposed, undernourished populations. We evaluated whether dietary intake of OCM nutrients (including vitamins B2, B6, folate (B9), and B12) was associated with arsenic metabolism in a more nourished population exposed to lower arsenic than previously studied. Dietary intake of OCM nutrients and urine arsenic was evaluated in 405 participants from the Strong Heart Study. Arsenic exposure was measured as the sum of iAs, monomethylarsonate (MMA) and dimethylarsenate (DMA) in urine. Arsenic metabolism was measured as the individual percentages of each metabolite over their sum (iAs%, MMA%, DMA%). In adjusted models, increasing intake of vitamins B2 and B6 was associated with modest but significant decreases in iAs% and MMA% and increases in DMA%. A significant interaction was found between high folate and B6 with enhanced arsenic metabolism efficiency. Our findings suggest OCM nutrients may influence arsenic metabolism in populations with moderate arsenic exposure. Stronger and independent associations were observed with B2 and B6, vitamins previously understudied in relation to arsenic. Research is needed to evaluate whether targeting B-vitamin intake can serve as a strategy for the prevention of arsenic-related health effects at low-moderate arsenic exposure.
AB - B-vitamins involved in one-carbon metabolism (OCM) can affect arsenic metabolism efficiency in highly arsenic exposed, undernourished populations. We evaluated whether dietary intake of OCM nutrients (including vitamins B2, B6, folate (B9), and B12) was associated with arsenic metabolism in a more nourished population exposed to lower arsenic than previously studied. Dietary intake of OCM nutrients and urine arsenic was evaluated in 405 participants from the Strong Heart Study. Arsenic exposure was measured as the sum of iAs, monomethylarsonate (MMA) and dimethylarsenate (DMA) in urine. Arsenic metabolism was measured as the individual percentages of each metabolite over their sum (iAs%, MMA%, DMA%). In adjusted models, increasing intake of vitamins B2 and B6 was associated with modest but significant decreases in iAs% and MMA% and increases in DMA%. A significant interaction was found between high folate and B6 with enhanced arsenic metabolism efficiency. Our findings suggest OCM nutrients may influence arsenic metabolism in populations with moderate arsenic exposure. Stronger and independent associations were observed with B2 and B6, vitamins previously understudied in relation to arsenic. Research is needed to evaluate whether targeting B-vitamin intake can serve as a strategy for the prevention of arsenic-related health effects at low-moderate arsenic exposure.
KW - Arsenic metabolism
KW - B-vitamins
KW - Dietary intake
KW - One-carbon metabolism
KW - Strong Heart Study
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UR - http://www.scopus.com/inward/citedby.url?scp=85018931179&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2017.05.004
DO - 10.1016/j.fct.2017.05.004
M3 - Article
C2 - 28479390
AN - SCOPUS:85018931179
SN - 0278-6915
VL - 105
SP - 387
EP - 397
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -
