Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure

Evidence from the Strong Heart Study

Miranda Jones Spratlen, Mary V. Gamble, Maria Grau-Perez, Chin Chi Kuo, Lyle G. Best, Joseph Yracheta, Kevin Francesconi, Walter Goessler, Yasmin Mossavar-Rahmani, Meghan Hall, Jason G. Umans, Amanda Fretts, Ana Navas-Acien

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

B-vitamins involved in one-carbon metabolism (OCM) can affect arsenic metabolism efficiency in highly arsenic exposed, undernourished populations. We evaluated whether dietary intake of OCM nutrients (including vitamins B2, B6, folate (B9), and B12) was associated with arsenic metabolism in a more nourished population exposed to lower arsenic than previously studied. Dietary intake of OCM nutrients and urine arsenic was evaluated in 405 participants from the Strong Heart Study. Arsenic exposure was measured as the sum of iAs, monomethylarsonate (MMA) and dimethylarsenate (DMA) in urine. Arsenic metabolism was measured as the individual percentages of each metabolite over their sum (iAs%, MMA%, DMA%). In adjusted models, increasing intake of vitamins B2 and B6 was associated with modest but significant decreases in iAs% and MMA% and increases in DMA%. A significant interaction was found between high folate and B6 with enhanced arsenic metabolism efficiency. Our findings suggest OCM nutrients may influence arsenic metabolism in populations with moderate arsenic exposure. Stronger and independent associations were observed with B2 and B6, vitamins previously understudied in relation to arsenic. Research is needed to evaluate whether targeting B-vitamin intake can serve as a strategy for the prevention of arsenic-related health effects at low-moderate arsenic exposure.

Original languageEnglish (US)
Pages (from-to)387-397
Number of pages11
JournalFood and Chemical Toxicology
Volume105
DOIs
StatePublished - Jul 1 2017

Fingerprint

Arsenic
arsenic
Metabolism
Carbon
heart
metabolism
carbon
Vitamin B 6
Riboflavin
riboflavin
Nutrients
Vitamin B Complex
vitamin B complex
at-risk population
pyridoxine
Folic Acid
folic acid
Food
food intake
nutrients

Keywords

  • Arsenic metabolism
  • B-vitamins
  • Dietary intake
  • One-carbon metabolism
  • Strong Heart Study

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Spratlen, M. J., Gamble, M. V., Grau-Perez, M., Kuo, C. C., Best, L. G., Yracheta, J., ... Navas-Acien, A. (2017). Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: Evidence from the Strong Heart Study. Food and Chemical Toxicology, 105, 387-397. https://doi.org/10.1016/j.fct.2017.05.004

Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure : Evidence from the Strong Heart Study. / Spratlen, Miranda Jones; Gamble, Mary V.; Grau-Perez, Maria; Kuo, Chin Chi; Best, Lyle G.; Yracheta, Joseph; Francesconi, Kevin; Goessler, Walter; Mossavar-Rahmani, Yasmin; Hall, Meghan; Umans, Jason G.; Fretts, Amanda; Navas-Acien, Ana.

In: Food and Chemical Toxicology, Vol. 105, 01.07.2017, p. 387-397.

Research output: Contribution to journalArticle

Spratlen, MJ, Gamble, MV, Grau-Perez, M, Kuo, CC, Best, LG, Yracheta, J, Francesconi, K, Goessler, W, Mossavar-Rahmani, Y, Hall, M, Umans, JG, Fretts, A & Navas-Acien, A 2017, 'Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: Evidence from the Strong Heart Study', Food and Chemical Toxicology, vol. 105, pp. 387-397. https://doi.org/10.1016/j.fct.2017.05.004
Spratlen, Miranda Jones ; Gamble, Mary V. ; Grau-Perez, Maria ; Kuo, Chin Chi ; Best, Lyle G. ; Yracheta, Joseph ; Francesconi, Kevin ; Goessler, Walter ; Mossavar-Rahmani, Yasmin ; Hall, Meghan ; Umans, Jason G. ; Fretts, Amanda ; Navas-Acien, Ana. / Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure : Evidence from the Strong Heart Study. In: Food and Chemical Toxicology. 2017 ; Vol. 105. pp. 387-397.
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