Arrhythmogenic right ventricular cardiomyopathy (ARVC/D): A systematic literature review

Jorge Romero, Eeliany Mejia-Lopez, Carlos Manrique, Richard Lucariello

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a genetic form of cardiomyopathy (CM) usually transmitted with an autosomal dominant pattern. It primary affects the right ventricle (RV), but may involve the left ventricle (LV) and culminate in biventricular heart failure (HF), life threatening ventricular arrhythmias and sudden cardiac death (SCD). It accounts for 11%-22% of cases of SCD in the young athlete population. Pathologically is characterized by myocardial atrophy, fibrofatty replacement and chamber dilation. Diagnosis is often difficult due to the nonspecific nature of the disease and the broad spectrum of phenotypic variations. Therefore consensus diagnostic criteria have been developed and combined electrocardiography, echocardiography, cardiac magnetic resonance imaging (CMRI) and myocardial biopsy. Early detection, family screening and risk stratification are the cornerstones in the diagnostic evaluation. Implantable cardioverter-defibrillator (ICD) implantation, ablative procedures and heart transplantation are currently the main therapeutic options.

Original languageEnglish (US)
Pages (from-to)97-114
Number of pages18
JournalClinical Medicine Insights: Cardiology
Volume7
DOIs
StatePublished - May 21 2013

Keywords

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC/D)
  • Cardiomyopathy
  • Sudden cardiac death
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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