Are neuropathological conditions relevant to ethylmercury exposure?

Michael Aschner, Sandra Ceccatelli

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Mercury and mercurial compounds are among the environmentally ubiquitous substances most toxic to both wildlife and humans. Once released into the environment from both natural and anthropogenic sources, mercury exists mainly as three different molecular species: elemental, inorganic, and organic. Potential health risks have been reported from exposure to all forms; however, of particular concern for human exposure relate to the potent neurotoxic effects of methylmercury (MeHg), especially for the developing nervous system. The general population is primarily exposed to MeHg by seafood consumption. In addition, some pharmaceuticals, including vaccines, have been, and some continue to be, a ubiquitous source of exposure to mercurials. A significant controversy has been whether the vaccine preservative ethylmercury thiosalicylate, commonly known as thimerosal, could cause the development of autism. In this review, we have discussed the hypothesis that exposure to thimerosal during childhood may be a primary cause of autism. The conclusion is that there are no reliable data indicating that administration of vaccines containing thimerosal is a primary cause of autism. However, one cannot rule out the possibility that the individual gene profile and/or gene-environment interactions may play a role in modulating the response to acquired risk by modifying the individual susceptibility.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalNeurotoxicity Research
Volume18
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Thimerosal
Autistic Disorder
Vaccines
Mercury
Genes
Mercury Compounds
Seafood
Gene-Environment Interaction
Poisons
Health risks
Neurology
Nervous System
Health
Pharmaceutical Preparations
Population

Keywords

  • Autism
  • Ethylmercury
  • Mercury
  • Neuropathology
  • Thimerosal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Are neuropathological conditions relevant to ethylmercury exposure? / Aschner, Michael; Ceccatelli, Sandra.

In: Neurotoxicity Research, Vol. 18, No. 1, 2010, p. 59-68.

Research output: Contribution to journalArticle

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