Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration

Assumpta A. Madu, Martin Mayers, Ruth Perkins, Weiguo Liu, George L. Drusano, Resham Aswani, Christian N. Madu, Michael H. Miller

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The overall importance of the peak or the mean serum concentrations as predictors of ocular drug penetration is unknown. To address this fundamental question with an agent which shows promise as adjunctive therapy in the treatment of endophthalmitis, we studied the penetration of ciprofloxacin into the aqueous and vitreous humors following three different modes of systemic administration. New Zealand white rabbits received either a single bolus dose (40 mg kg-1), three intermittent doses of 13.33 mg kg-1 evenly spaced over an 8 hr period, or a continuous infusion of 40 mg kg-1 over an 8 hr period. Pharmacokinetic analysis was performed using RSTRIP II, a non-linear, least square regression model analysis program, The serum area under the concentration-time curve (AUC) values for each mode of drug administration were similar: 32.9 μg hr ml-1 for single dose, 31.9 μg hr ml-1 for intermittent dose, and 33.8 μg hr ml-1 for continuous infusion modes. The percentage penetration into the aqueous and vitreous were also similar; 30.5% and 6.5% for a single dose, 31.6% and 7.4% for intermittent doses and 30.0% and 7.5% for continuous infusion. The penetration into the aqueous and Vitreous humors was not influenced by mode of administration. As with other quinolones we have studied, elimination rates were similar for the central and peripheral compartments in the post-distributive phase. Vitreous humor ciprofloxacin concentrations achieved were below that which inhibits most Staphylococcus epidermidis, the most common isolate in patients with post-operative endophthalmitis.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalExperimental Eye Research
Volume63
Issue number2
DOIs
StatePublished - Aug 1996

Fingerprint

Vitreous Body
Ciprofloxacin
Endophthalmitis
Aqueous Humor
Staphylococcus epidermidis
Quinolones
Least-Squares Analysis
Serum
Pharmaceutical Preparations
Pharmacokinetics
Regression Analysis
Rabbits
Therapeutics

Keywords

  • Animal model
  • Ciprofloxacin
  • Pharmacodynamics
  • Pharmacokinetics
  • Vitreous humor

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Madu, A. A., Mayers, M., Perkins, R., Liu, W., Drusano, G. L., Aswani, R., ... Miller, M. H. (1996). Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration. Experimental Eye Research, 63(2), 129-136. https://doi.org/10.1006/exer.1996.0101

Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration. / Madu, Assumpta A.; Mayers, Martin; Perkins, Ruth; Liu, Weiguo; Drusano, George L.; Aswani, Resham; Madu, Christian N.; Miller, Michael H.

In: Experimental Eye Research, Vol. 63, No. 2, 08.1996, p. 129-136.

Research output: Contribution to journalArticle

Madu, AA, Mayers, M, Perkins, R, Liu, W, Drusano, GL, Aswani, R, Madu, CN & Miller, MH 1996, 'Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration', Experimental Eye Research, vol. 63, no. 2, pp. 129-136. https://doi.org/10.1006/exer.1996.0101
Madu, Assumpta A. ; Mayers, Martin ; Perkins, Ruth ; Liu, Weiguo ; Drusano, George L. ; Aswani, Resham ; Madu, Christian N. ; Miller, Michael H. / Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration. In: Experimental Eye Research. 1996 ; Vol. 63, No. 2. pp. 129-136.
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