Aptamer:toxin conjugates that specifically target prostate tumor cells

Ted C. Chu; John W. Marks; Laura A. Lavery; Sarah Faulkner; Michael G. Rosenblum; Andrew D. Ellington; Matthew Levy

doi:10.1158/0008-5472.CAN-05-4583

Aptamer:toxin conjugates that specifically target prostate tumor cells

Ted C. Chu, John W. Marks, Laura A. Lavery, Sarah Faulkner, Michael G. Rosenblum, Andrew D. Ellington, Matthew Levy

Research output: Contribution to journal › Article › peer-review

259 Scopus citations

Abstract

We have used RNA aptamer:gelonin conjugates to target and specifically destroy cells overexpressing the known cancer biomarker prostate-specific membrane antigen (PSMA). Aptamer:toxin conjugates have an IC₅₀ of 27 nmol/L and display an increased potency of at least 600-fold relative to cells that do not express PSMA. The aptamer not only promotes uptake into target cells but also decreases the toxicity of gelonin in non-target cells. These results validate the notion that "escort aptamers" may be useful for the treatment of specific tumors expressing unique antigen targets.

Original language	English (US)
Pages (from-to)	5989-5992
Number of pages	4
Journal	Cancer research
Volume	66
Issue number	12
DOIs	https://doi.org/10.1158/0008-5472.CAN-05-4583
State	Published - Jun 15 2006
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/0008-5472.CAN-05-4583

Cite this

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abstract = "We have used RNA aptamer:gelonin conjugates to target and specifically destroy cells overexpressing the known cancer biomarker prostate-specific membrane antigen (PSMA). Aptamer:toxin conjugates have an IC50 of 27 nmol/L and display an increased potency of at least 600-fold relative to cells that do not express PSMA. The aptamer not only promotes uptake into target cells but also decreases the toxicity of gelonin in non-target cells. These results validate the notion that {"}escort aptamers{"} may be useful for the treatment of specific tumors expressing unique antigen targets.",

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AU - Chu, Ted C.

AU - Marks, John W.

AU - Lavery, Laura A.

AU - Faulkner, Sarah

AU - Rosenblum, Michael G.

AU - Ellington, Andrew D.

AU - Levy, Matthew

PY - 2006/6/15

Y1 - 2006/6/15

N2 - We have used RNA aptamer:gelonin conjugates to target and specifically destroy cells overexpressing the known cancer biomarker prostate-specific membrane antigen (PSMA). Aptamer:toxin conjugates have an IC50 of 27 nmol/L and display an increased potency of at least 600-fold relative to cells that do not express PSMA. The aptamer not only promotes uptake into target cells but also decreases the toxicity of gelonin in non-target cells. These results validate the notion that "escort aptamers" may be useful for the treatment of specific tumors expressing unique antigen targets.

AB - We have used RNA aptamer:gelonin conjugates to target and specifically destroy cells overexpressing the known cancer biomarker prostate-specific membrane antigen (PSMA). Aptamer:toxin conjugates have an IC50 of 27 nmol/L and display an increased potency of at least 600-fold relative to cells that do not express PSMA. The aptamer not only promotes uptake into target cells but also decreases the toxicity of gelonin in non-target cells. These results validate the notion that "escort aptamers" may be useful for the treatment of specific tumors expressing unique antigen targets.

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Aptamer:toxin conjugates that specifically target prostate tumor cells

Abstract

ASJC Scopus subject areas

UN SDGs

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