Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

Hector M. González; Wassim Tarraf; Xueqiu Jian; Priscilla M. Vásquez; Robert Kaplan; Bharat Thyagarajan; Martha Daviglus; Melissa Lamar; Linda C. Gallo; Donglin Zeng; Myriam Fornage

doi:10.1038/s41598-018-35573-3

Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

Hector M. González, Wassim Tarraf, Xueqiu Jian, Priscilla M. Vásquez, Robert Kaplan, Bharat Thyagarajan, Martha Daviglus, Melissa Lamar, Linda C. Gallo, Donglin Zeng, Myriam Fornage

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.

Original language	English (US)
Article number	17578
Journal	Scientific reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-35573-3
State	Published - Dec 1 2018

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González, H. M., Tarraf, W., Jian, X., Vásquez, P. M., Kaplan, R., Thyagarajan, B., Daviglus, M., Lamar, M., Gallo, L. C., Zeng, D., & Fornage, M. (2018). Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). Scientific reports, 8(1), Article 17578. https://doi.org/10.1038/s41598-018-35573-3

González, HM, Tarraf, W, Jian, X, Vásquez, PM, Kaplan, R, Thyagarajan, B, Daviglus, M, Lamar, M, Gallo, LC, Zeng, D & Fornage, M 2018, 'Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)', Scientific reports, vol. 8, no. 1, 17578. https://doi.org/10.1038/s41598-018-35573-3

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abstract = "The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer{\textquoteright}s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.",

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AU - Kaplan, Robert

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Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

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