Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

Hector M. González, Wassim Tarraf, Xueqiu Jian, Priscilla M. Vásquez, Robert C. Kaplan, Bharat Thyagarajan, Martha Daviglus, Melissa Lamar, Linda C. Gallo, Donglin Zeng, Myriam Fornage

Research output: Contribution to journalArticle

Abstract

The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.

Original languageEnglish (US)
Article number17578
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

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Apolipoproteins E
Hispanic Americans
Genotype
Apolipoprotein E4
Alzheimer Disease
Protein Isoforms
Cardiovascular Diseases
Cholesterol
Population

ASJC Scopus subject areas

  • General

Cite this

Apolipoprotein E genotypes among diverse middle-aged and older Latinos : Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). / González, Hector M.; Tarraf, Wassim; Jian, Xueqiu; Vásquez, Priscilla M.; Kaplan, Robert C.; Thyagarajan, Bharat; Daviglus, Martha; Lamar, Melissa; Gallo, Linda C.; Zeng, Donglin; Fornage, Myriam.

In: Scientific Reports, Vol. 8, No. 1, 17578, 01.12.2018.

Research output: Contribution to journalArticle

González, HM, Tarraf, W, Jian, X, Vásquez, PM, Kaplan, RC, Thyagarajan, B, Daviglus, M, Lamar, M, Gallo, LC, Zeng, D & Fornage, M 2018, 'Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)', Scientific Reports, vol. 8, no. 1, 17578. https://doi.org/10.1038/s41598-018-35573-3
González, Hector M. ; Tarraf, Wassim ; Jian, Xueqiu ; Vásquez, Priscilla M. ; Kaplan, Robert C. ; Thyagarajan, Bharat ; Daviglus, Martha ; Lamar, Melissa ; Gallo, Linda C. ; Zeng, Donglin ; Fornage, Myriam. / Apolipoprotein E genotypes among diverse middle-aged and older Latinos : Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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