Apolipoprotein E and category fluency

Evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease

Virginia M. Rosen, Trey Sunderland, James Levy, Angela Harwell, Lori McGee, Christopher Hammond, Deepa Bhupali, Karen Putnam, Judy Bergeson, Charlene Lefkowitz

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Two groups of non-demented individuals, who differed on genetic risk for Alzheimer's disease (AD) based on their apolipoprotein E (APOE) genotype, were tested on a category fluency task. Twenty ε4 carriers and twenty ε4 non-carriers were tape recorded while saying animal names for ten minutes. Five measures were examined: total names generated; total clusters; mean cluster size; mean within-cluster retrieval time; and mean between-cluster retrieval time. Groups were matched on age and education and scored as normal on a battery of psychometric tests. The ε4 carriers generated significantly fewer names and clusters, and took significantly longer to access clusters, when compared to the ε4 non-carriers. No group differences were found for cluster size or within-cluster retrieval times. We previously reported [Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia 40, 2226-2233] that the ε4 carriers in the present study scored significantly lower than the ε4 non-carriers on a measure of working memory/attentional capacity [Operation Span Task, see Turner, M. L., Engle, R. W. (1989). Is working memory capacity task dependent? Journal of Memory and Language 28, 127-154]. In the present study, a significant negative relationship found between span performance and between-cluster retrieval times suggested that reduced attentional capacity may have negatively impacted semantic access for the ε4 carriers. Finally, we found significant relationships between a Trail Making Test [Reitan, R. M. (1992). Trail Making Test, manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory] "switch" measure (Form B-Form A) and three of the five fluency measures. The findings suggested that the ε4 carrier's reduced attentional capacity may have interfered with their covertly shifting attention among subcategories in the fluency task, resulting in fewer names and clusters generated and longer times to access clusters.

Original languageEnglish (US)
Pages (from-to)647-658
Number of pages12
JournalNeuropsychologia
Volume43
Issue number4
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Apolipoproteins E
Semantics
Alzheimer Disease
Names
Short-Term Memory
Trail Making Test
Neuropsychology
Psychometrics
Research Design
Language
Genotype
Education

Keywords

  • APOE
  • Attention
  • Retrieval
  • Switching
  • Working memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Apolipoprotein E and category fluency : Evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease. / Rosen, Virginia M.; Sunderland, Trey; Levy, James; Harwell, Angela; McGee, Lori; Hammond, Christopher; Bhupali, Deepa; Putnam, Karen; Bergeson, Judy; Lefkowitz, Charlene.

In: Neuropsychologia, Vol. 43, No. 4, 2005, p. 647-658.

Research output: Contribution to journalArticle

Rosen, VM, Sunderland, T, Levy, J, Harwell, A, McGee, L, Hammond, C, Bhupali, D, Putnam, K, Bergeson, J & Lefkowitz, C 2005, 'Apolipoprotein E and category fluency: Evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease', Neuropsychologia, vol. 43, no. 4, pp. 647-658. https://doi.org/10.1016/j.neuropsychologia.2004.06.022
Rosen, Virginia M. ; Sunderland, Trey ; Levy, James ; Harwell, Angela ; McGee, Lori ; Hammond, Christopher ; Bhupali, Deepa ; Putnam, Karen ; Bergeson, Judy ; Lefkowitz, Charlene. / Apolipoprotein E and category fluency : Evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease. In: Neuropsychologia. 2005 ; Vol. 43, No. 4. pp. 647-658.
@article{6b8e63212c38496bb16a64c2a5022007,
title = "Apolipoprotein E and category fluency: Evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease",
abstract = "Two groups of non-demented individuals, who differed on genetic risk for Alzheimer's disease (AD) based on their apolipoprotein E (APOE) genotype, were tested on a category fluency task. Twenty ε4 carriers and twenty ε4 non-carriers were tape recorded while saying animal names for ten minutes. Five measures were examined: total names generated; total clusters; mean cluster size; mean within-cluster retrieval time; and mean between-cluster retrieval time. Groups were matched on age and education and scored as normal on a battery of psychometric tests. The ε4 carriers generated significantly fewer names and clusters, and took significantly longer to access clusters, when compared to the ε4 non-carriers. No group differences were found for cluster size or within-cluster retrieval times. We previously reported [Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia 40, 2226-2233] that the ε4 carriers in the present study scored significantly lower than the ε4 non-carriers on a measure of working memory/attentional capacity [Operation Span Task, see Turner, M. L., Engle, R. W. (1989). Is working memory capacity task dependent? Journal of Memory and Language 28, 127-154]. In the present study, a significant negative relationship found between span performance and between-cluster retrieval times suggested that reduced attentional capacity may have negatively impacted semantic access for the ε4 carriers. Finally, we found significant relationships between a Trail Making Test [Reitan, R. M. (1992). Trail Making Test, manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory] {"}switch{"} measure (Form B-Form A) and three of the five fluency measures. The findings suggested that the ε4 carrier's reduced attentional capacity may have interfered with their covertly shifting attention among subcategories in the fluency task, resulting in fewer names and clusters generated and longer times to access clusters.",
keywords = "APOE, Attention, Retrieval, Switching, Working memory",
author = "Rosen, {Virginia M.} and Trey Sunderland and James Levy and Angela Harwell and Lori McGee and Christopher Hammond and Deepa Bhupali and Karen Putnam and Judy Bergeson and Charlene Lefkowitz",
year = "2005",
doi = "10.1016/j.neuropsychologia.2004.06.022",
language = "English (US)",
volume = "43",
pages = "647--658",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Apolipoprotein E and category fluency

T2 - Evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease

AU - Rosen, Virginia M.

AU - Sunderland, Trey

AU - Levy, James

AU - Harwell, Angela

AU - McGee, Lori

AU - Hammond, Christopher

AU - Bhupali, Deepa

AU - Putnam, Karen

AU - Bergeson, Judy

AU - Lefkowitz, Charlene

PY - 2005

Y1 - 2005

N2 - Two groups of non-demented individuals, who differed on genetic risk for Alzheimer's disease (AD) based on their apolipoprotein E (APOE) genotype, were tested on a category fluency task. Twenty ε4 carriers and twenty ε4 non-carriers were tape recorded while saying animal names for ten minutes. Five measures were examined: total names generated; total clusters; mean cluster size; mean within-cluster retrieval time; and mean between-cluster retrieval time. Groups were matched on age and education and scored as normal on a battery of psychometric tests. The ε4 carriers generated significantly fewer names and clusters, and took significantly longer to access clusters, when compared to the ε4 non-carriers. No group differences were found for cluster size or within-cluster retrieval times. We previously reported [Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia 40, 2226-2233] that the ε4 carriers in the present study scored significantly lower than the ε4 non-carriers on a measure of working memory/attentional capacity [Operation Span Task, see Turner, M. L., Engle, R. W. (1989). Is working memory capacity task dependent? Journal of Memory and Language 28, 127-154]. In the present study, a significant negative relationship found between span performance and between-cluster retrieval times suggested that reduced attentional capacity may have negatively impacted semantic access for the ε4 carriers. Finally, we found significant relationships between a Trail Making Test [Reitan, R. M. (1992). Trail Making Test, manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory] "switch" measure (Form B-Form A) and three of the five fluency measures. The findings suggested that the ε4 carrier's reduced attentional capacity may have interfered with their covertly shifting attention among subcategories in the fluency task, resulting in fewer names and clusters generated and longer times to access clusters.

AB - Two groups of non-demented individuals, who differed on genetic risk for Alzheimer's disease (AD) based on their apolipoprotein E (APOE) genotype, were tested on a category fluency task. Twenty ε4 carriers and twenty ε4 non-carriers were tape recorded while saying animal names for ten minutes. Five measures were examined: total names generated; total clusters; mean cluster size; mean within-cluster retrieval time; and mean between-cluster retrieval time. Groups were matched on age and education and scored as normal on a battery of psychometric tests. The ε4 carriers generated significantly fewer names and clusters, and took significantly longer to access clusters, when compared to the ε4 non-carriers. No group differences were found for cluster size or within-cluster retrieval times. We previously reported [Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia 40, 2226-2233] that the ε4 carriers in the present study scored significantly lower than the ε4 non-carriers on a measure of working memory/attentional capacity [Operation Span Task, see Turner, M. L., Engle, R. W. (1989). Is working memory capacity task dependent? Journal of Memory and Language 28, 127-154]. In the present study, a significant negative relationship found between span performance and between-cluster retrieval times suggested that reduced attentional capacity may have negatively impacted semantic access for the ε4 carriers. Finally, we found significant relationships between a Trail Making Test [Reitan, R. M. (1992). Trail Making Test, manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory] "switch" measure (Form B-Form A) and three of the five fluency measures. The findings suggested that the ε4 carrier's reduced attentional capacity may have interfered with their covertly shifting attention among subcategories in the fluency task, resulting in fewer names and clusters generated and longer times to access clusters.

KW - APOE

KW - Attention

KW - Retrieval

KW - Switching

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=13844277058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844277058&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2004.06.022

DO - 10.1016/j.neuropsychologia.2004.06.022

M3 - Article

VL - 43

SP - 647

EP - 658

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 4

ER -