APOE Alleles and Extreme Human Longevity

Paola Sebastiani, Anastasia Gurinovich, Marianne Nygaard, Takashi Sasaki, Benjamin Sweigart, Harold Bae, Stacy L. Andersen, Francesco Villa, Gil Atzmon, Kaare Christensen, Yasumichi Arai, Nir Barzilai, Annibale Puca, Lene Christiansen, Nobuyoshi Hirose, Thomas T. Perls

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles ε2ε3 and ε4 and extreme human longevity and age at death. By using three different genetic models and two definitions of extreme longevity based on either a threshold model or age at death, we show that ε4 is associated with a substantially decreased odds for extreme longevity, and increased risk for death that persists even beyond ages reached by less than 1% of the population. We also show that carrying the ε2ε2 or ε2ε3 genotype is associated with significantly increased odds to reach extreme longevity, with decreased risk for death compared with carrying the genotype ε3ε3 but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.

Original languageEnglish (US)
Pages (from-to)44-51
Number of pages8
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume74
Issue number1
DOIs
StatePublished - Jan 1 2019

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Alleles
Genotype
Population
New England
Retirement
Genetic Models
Risk Reduction Behavior
Health
Genes

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., ... Perls, T. T. (2019). APOE Alleles and Extreme Human Longevity. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(1), 44-51. https://doi.org/10.1093/gerona/gly174

APOE Alleles and Extreme Human Longevity. / Sebastiani, Paola; Gurinovich, Anastasia; Nygaard, Marianne; Sasaki, Takashi; Sweigart, Benjamin; Bae, Harold; Andersen, Stacy L.; Villa, Francesco; Atzmon, Gil; Christensen, Kaare; Arai, Yasumichi; Barzilai, Nir; Puca, Annibale; Christiansen, Lene; Hirose, Nobuyoshi; Perls, Thomas T.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 74, No. 1, 01.01.2019, p. 44-51.

Research output: Contribution to journalArticle

Sebastiani, P, Gurinovich, A, Nygaard, M, Sasaki, T, Sweigart, B, Bae, H, Andersen, SL, Villa, F, Atzmon, G, Christensen, K, Arai, Y, Barzilai, N, Puca, A, Christiansen, L, Hirose, N & Perls, TT 2019, 'APOE Alleles and Extreme Human Longevity' The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 1, pp. 44-51. https://doi.org/10.1093/gerona/gly174
Sebastiani, Paola ; Gurinovich, Anastasia ; Nygaard, Marianne ; Sasaki, Takashi ; Sweigart, Benjamin ; Bae, Harold ; Andersen, Stacy L. ; Villa, Francesco ; Atzmon, Gil ; Christensen, Kaare ; Arai, Yasumichi ; Barzilai, Nir ; Puca, Annibale ; Christiansen, Lene ; Hirose, Nobuyoshi ; Perls, Thomas T. / APOE Alleles and Extreme Human Longevity. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2019 ; Vol. 74, No. 1. pp. 44-51.
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