Abstract
We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles ε2ε3 and ε4 and extreme human longevity and age at death. By using three different genetic models and two definitions of extreme longevity based on either a threshold model or age at death, we show that ε4 is associated with a substantially decreased odds for extreme longevity, and increased risk for death that persists even beyond ages reached by less than 1% of the population. We also show that carrying the ε2ε2 or ε2ε3 genotype is associated with significantly increased odds to reach extreme longevity, with decreased risk for death compared with carrying the genotype ε3ε3 but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 44-51 |
| Number of pages | 8 |
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| Volume | 74 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
Cite this
APOE Alleles and Extreme Human Longevity. / Sebastiani, Paola; Gurinovich, Anastasia; Nygaard, Marianne; Sasaki, Takashi; Sweigart, Benjamin; Bae, Harold; Andersen, Stacy L.; Villa, Francesco; Atzmon, Gil; Christensen, Kaare; Arai, Yasumichi; Barzilai, Nir; Puca, Annibale; Christiansen, Lene; Hirose, Nobuyoshi; Perls, Thomas T.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 74, No. 1, 01.01.2019, p. 44-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - APOE Alleles and Extreme Human Longevity
AU - Sebastiani, Paola
AU - Gurinovich, Anastasia
AU - Nygaard, Marianne
AU - Sasaki, Takashi
AU - Sweigart, Benjamin
AU - Bae, Harold
AU - Andersen, Stacy L.
AU - Villa, Francesco
AU - Atzmon, Gil
AU - Christensen, Kaare
AU - Arai, Yasumichi
AU - Barzilai, Nir
AU - Puca, Annibale
AU - Christiansen, Lene
AU - Hirose, Nobuyoshi
AU - Perls, Thomas T.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles ε2ε3 and ε4 and extreme human longevity and age at death. By using three different genetic models and two definitions of extreme longevity based on either a threshold model or age at death, we show that ε4 is associated with a substantially decreased odds for extreme longevity, and increased risk for death that persists even beyond ages reached by less than 1% of the population. We also show that carrying the ε2ε2 or ε2ε3 genotype is associated with significantly increased odds to reach extreme longevity, with decreased risk for death compared with carrying the genotype ε3ε3 but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.
AB - We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles ε2ε3 and ε4 and extreme human longevity and age at death. By using three different genetic models and two definitions of extreme longevity based on either a threshold model or age at death, we show that ε4 is associated with a substantially decreased odds for extreme longevity, and increased risk for death that persists even beyond ages reached by less than 1% of the population. We also show that carrying the ε2ε2 or ε2ε3 genotype is associated with significantly increased odds to reach extreme longevity, with decreased risk for death compared with carrying the genotype ε3ε3 but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.
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U2 - 10.1093/gerona/gly174
DO - 10.1093/gerona/gly174
M3 - Article
VL - 74
SP - 44
EP - 51
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 1
ER -