APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention

The Pounds Lost Trial

Xiaomin Zhang, Qibin Qi, George A. Bray, Frank B. Hu, Frank M. Sacks, Lu Qi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The apolipoprotein A5 gene (APOA5) is a major gene that regulates lipid metabolism and is modulated by dietary factors. A novel variant rs964184 in APOA5 was identified to be associated with lipids in genome-wide association studies. Objective: We examined whether this variant modified changes in lipid concentrations in response to a 2-y weight-loss diet intervention in a randomized trial. Design: The current analyses were secondary analyses of a data set from the Pounds Lost Trial. We genotyped APOA5 rs964184 in 734 overweight or obese adults who were randomly assigned to one of 4 diets that differed in percentages of energy derived from fat, protein, and carbohydrate for 2 y. We evaluated changes in fasting serum concentrations of total cholesterol (TC), LDL cholesterol, HDL cholesterol, and triglyceride from baseline to 2 y of follow-up. Results: After a 2-y dietary intervention, we showed significant interactions between the APOA5 rs964184 polymorphism and dietary fat intake (low compared with high) in the determination of changes in TC, LDL cholesterol, and HDL cholesterol (P-interaction = 0.007, 0.017, and 0.006, respectively). In the low-fat intake group (20% of energy derived from fat), carriers of the risk allele (G allele) exhibited greater reductions in TC and LDL cholesterol than did noncarriers (P = 0.036 and 0.039, respectively), whereas in the high-fat diet group (40% of energy derived from fat), participants with the G allele had a greater increase in HDL cholesterol than did participants without this allele (P = 0.038). Conclusion: Our data showed better improvement in lipid profiles from long-term low-fat diet intake in the APOA5 rs964184 risk allele. The Pounds Lost Trial was registered at clinicaltrials.gov as NCT00072995.

Original languageEnglish (US)
Pages (from-to)917-922
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume96
Issue number4
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Fingerprint

Reducing Diet
Genotype
Lipids
Alleles
Fats
LDL Cholesterol
HDL Cholesterol
Genes
Cholesterol
Fat-Restricted Diet
Genome-Wide Association Study
Dietary Fats
High Fat Diet
Lipid Metabolism
Apolipoprotein A-V
Fasting
Triglycerides
Carbohydrates
Diet
Serum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention : The Pounds Lost Trial. / Zhang, Xiaomin; Qi, Qibin; Bray, George A.; Hu, Frank B.; Sacks, Frank M.; Qi, Lu.

In: American Journal of Clinical Nutrition, Vol. 96, No. 4, 01.10.2012, p. 917-922.

Research output: Contribution to journalArticle

Zhang, Xiaomin ; Qi, Qibin ; Bray, George A. ; Hu, Frank B. ; Sacks, Frank M. ; Qi, Lu. / APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention : The Pounds Lost Trial. In: American Journal of Clinical Nutrition. 2012 ; Vol. 96, No. 4. pp. 917-922.
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abstract = "Background: The apolipoprotein A5 gene (APOA5) is a major gene that regulates lipid metabolism and is modulated by dietary factors. A novel variant rs964184 in APOA5 was identified to be associated with lipids in genome-wide association studies. Objective: We examined whether this variant modified changes in lipid concentrations in response to a 2-y weight-loss diet intervention in a randomized trial. Design: The current analyses were secondary analyses of a data set from the Pounds Lost Trial. We genotyped APOA5 rs964184 in 734 overweight or obese adults who were randomly assigned to one of 4 diets that differed in percentages of energy derived from fat, protein, and carbohydrate for 2 y. We evaluated changes in fasting serum concentrations of total cholesterol (TC), LDL cholesterol, HDL cholesterol, and triglyceride from baseline to 2 y of follow-up. Results: After a 2-y dietary intervention, we showed significant interactions between the APOA5 rs964184 polymorphism and dietary fat intake (low compared with high) in the determination of changes in TC, LDL cholesterol, and HDL cholesterol (P-interaction = 0.007, 0.017, and 0.006, respectively). In the low-fat intake group (20{\%} of energy derived from fat), carriers of the risk allele (G allele) exhibited greater reductions in TC and LDL cholesterol than did noncarriers (P = 0.036 and 0.039, respectively), whereas in the high-fat diet group (40{\%} of energy derived from fat), participants with the G allele had a greater increase in HDL cholesterol than did participants without this allele (P = 0.038). Conclusion: Our data showed better improvement in lipid profiles from long-term low-fat diet intake in the APOA5 rs964184 risk allele. The Pounds Lost Trial was registered at clinicaltrials.gov as NCT00072995.",
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