TY - JOUR
T1 - Apathy correlates with cognitive performance, functional disability, and HIV RNA plasma levels in HIV-positive individuals
AU - Shapiro, Miriam E.
AU - Mahoney, Jeannette R.
AU - Zingman, Barry S.
AU - Pogge, David L.
AU - Verghese, Joe
N1 - Funding Information:
The authors would like to thank the research participants who enrolled in this study, all of the research staff who helped with data collection (especially Deena Peyser and Eugene Dolce), and the community HIV care providers who referred many of their patients to our study. This research was supported by funding from the National Institute of Allergy and Infectious Diseases [grant number P30AI051519-09s]. Address correspondence to: Miriam E. Shapiro, Department of Psychology, Fairleigh Dickinson University, 1000 River Road, Teaneck, NJ 07666, USA (E-mail: miriamshap@gmail.com).
PY - 2013/11/1
Y1 - 2013/11/1
N2 - We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.
AB - We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.
KW - Aging
KW - Apathy
KW - Cognitive performance
KW - Functional disability
KW - HIV
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U2 - 10.1080/13803395.2013.838941
DO - 10.1080/13803395.2013.838941
M3 - Article
C2 - 24090038
AN - SCOPUS:84886727297
SN - 1380-3395
VL - 35
SP - 934
EP - 945
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 9
ER -
