Apathy correlates with cognitive performance, functional disability, and HIV RNA plasma levels in HIV-positive individuals

Miriam E. Shapiro, Jeannette R. Mahoney, Barry S. Zingman, David L. Pogge, Joe Verghese

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.

Original languageEnglish (US)
Pages (from-to)934-945
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Volume35
Issue number9
DOIs
StatePublished - Nov 1 2013

Keywords

  • Aging
  • Apathy
  • Cognitive performance
  • Functional disability
  • HIV

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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