Apathy correlates with cognitive performance, functional disability, and HIV RNA plasma levels in HIV-positive individuals

Miriam E. Shapiro, Jeannette R. Mahoney, Barry S. Zingman, David L. Pogge, Joe Verghese

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.

Original languageEnglish (US)
Pages (from-to)934-945
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Volume35
Issue number9
DOIs
StatePublished - Nov 1 2013

Fingerprint

Apathy
HIV
RNA

Keywords

  • Aging
  • Apathy
  • Cognitive performance
  • Functional disability
  • HIV

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Clinical Psychology

Cite this

@article{7f3a545a1639478a8d6c5aa4d8a21674,
title = "Apathy correlates with cognitive performance, functional disability, and HIV RNA plasma levels in HIV-positive individuals",
abstract = "We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.",
keywords = "Aging, Apathy, Cognitive performance, Functional disability, HIV",
author = "Shapiro, {Miriam E.} and Mahoney, {Jeannette R.} and Zingman, {Barry S.} and Pogge, {David L.} and Joe Verghese",
year = "2013",
month = "11",
day = "1",
doi = "10.1080/13803395.2013.838941",
language = "English (US)",
volume = "35",
pages = "934--945",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "1380-3395",
publisher = "Psychology Press Ltd",
number = "9",

}

TY - JOUR

T1 - Apathy correlates with cognitive performance, functional disability, and HIV RNA plasma levels in HIV-positive individuals

AU - Shapiro, Miriam E.

AU - Mahoney, Jeannette R.

AU - Zingman, Barry S.

AU - Pogge, David L.

AU - Verghese, Joe

PY - 2013/11/1

Y1 - 2013/11/1

N2 - We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.

AB - We examined the relationship of apathy with neurocognitive performance, age, disease markers, and functional disability in 116 HIV-infected individuals. Apathy was assessed with the Apathy Evaluation Scale and was significantly associated with highest HIV plasma level, functional disability, and neurocognitive performance. Individuals with higher apathy levels demonstrated a stronger association between age and processing speed performance. Our findings suggest that apathy is related to poor neuropsychological functioning, HIV plasma levels, and increased functional disability in individuals with HIV. Additionally, to our knowledge, this is the first study to demonstrate an interactive effect of age and apathy on neuropsychological performance in HIV.

KW - Aging

KW - Apathy

KW - Cognitive performance

KW - Functional disability

KW - HIV

UR - http://www.scopus.com/inward/record.url?scp=84886727297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886727297&partnerID=8YFLogxK

U2 - 10.1080/13803395.2013.838941

DO - 10.1080/13803395.2013.838941

M3 - Article

C2 - 24090038

AN - SCOPUS:84886727297

VL - 35

SP - 934

EP - 945

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 1380-3395

IS - 9

ER -