Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results

Alvaro Camacho, Wassim Tarraf, Daniel E. Jimenez, Linda C. Gallo, Patricia Gonzalez, Robert C. Kaplan, Melissa Lamar, Tasneem Khambaty, Bharat Thyagarajan, Krista M. Perreira, Rosalba Hernandez, Jianwen Cai, Martha L. Daviglus, Sylvia Wassertheil-Smoller, Hector M. González

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The purpose of this study is to examine the association between verbal learning, fluency, and processing speed with anxious depression symptomatology (ADS) among diverse Hispanics. We hypothesized an inverse association of anxious depression with neurocognition among Hispanics of different heritage. Design: Data are from the Hispanic Community Health Study/Study of Latinos. The sample included 9,311participants aged 45-74 years (mean: 56.5 years). A latent class analysis of items from the Center for Epidemiological Studies for Depression scale and the Spielberger Trait Anxiety Inventory was used to derive an anxious depression construct. Neurocognitive measures included scores on the Brief Spanish English Verbal Learning Test (B-SEVLT, learning and recall trials), Word Fluency (WF), Digit Symbol Substitution (DSS) test, and a Global Cognitive Score (GCS). We fit survey linear regression models to test the associations between anxious depression symptomatology and cognitive function. We tested for effect modification by sex, Hispanic heritage, and age groups. Results: Among men, 71.6% reported low, 23.3% moderate, and 5.1% high ADS. Among women, 55.1% reported low, 33.2% moderate, and 11.8% high ADS. After controlling for age, sex, sociodemographic characteristics, cardiovascular risk factors and disease, and antidepressant use, we found significant inverse associations between moderate and high anxious depression (ref:low) with B-SEVLT learning and recall, DSS and GCS. Moderate, but not high, anxious depression was inversely associated with WF. Associations were not modified by sex, Hispanic heritage, or age. Conclusions: Increased anxious depression symptomatology is associated with decreased neurocognitive function among Hispanics. Longitudinal studies are needed to establish temporality and infer if negative emotional symptoms precede cognitive deficits.

Original languageEnglish (US)
JournalAmerican Journal of Geriatric Psychiatry
DOIs
StateAccepted/In press - 2017

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Hispanic Americans
Depression
Health
Verbal Learning
Linear Models
Learning
Neurobehavioral Manifestations
Sex Characteristics
Cognition
Antidepressive Agents
Longitudinal Studies
Epidemiologic Studies
Anxiety
Age Groups
Equipment and Supplies

Keywords

  • Anxious depression
  • Dysphoria
  • Hispanic/Latinos
  • Neurocognition

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults : Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results. / Camacho, Alvaro; Tarraf, Wassim; Jimenez, Daniel E.; Gallo, Linda C.; Gonzalez, Patricia; Kaplan, Robert C.; Lamar, Melissa; Khambaty, Tasneem; Thyagarajan, Bharat; Perreira, Krista M.; Hernandez, Rosalba; Cai, Jianwen; Daviglus, Martha L.; Wassertheil-Smoller, Sylvia; González, Hector M.

In: American Journal of Geriatric Psychiatry, 2017.

Research output: Contribution to journalArticle

Camacho, A, Tarraf, W, Jimenez, DE, Gallo, LC, Gonzalez, P, Kaplan, RC, Lamar, M, Khambaty, T, Thyagarajan, B, Perreira, KM, Hernandez, R, Cai, J, Daviglus, ML, Wassertheil-Smoller, S & González, HM 2017, 'Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results', American Journal of Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2017.06.002
Camacho, Alvaro ; Tarraf, Wassim ; Jimenez, Daniel E. ; Gallo, Linda C. ; Gonzalez, Patricia ; Kaplan, Robert C. ; Lamar, Melissa ; Khambaty, Tasneem ; Thyagarajan, Bharat ; Perreira, Krista M. ; Hernandez, Rosalba ; Cai, Jianwen ; Daviglus, Martha L. ; Wassertheil-Smoller, Sylvia ; González, Hector M. / Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults : Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results. In: American Journal of Geriatric Psychiatry. 2017.
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abstract = "Objective: The purpose of this study is to examine the association between verbal learning, fluency, and processing speed with anxious depression symptomatology (ADS) among diverse Hispanics. We hypothesized an inverse association of anxious depression with neurocognition among Hispanics of different heritage. Design: Data are from the Hispanic Community Health Study/Study of Latinos. The sample included 9,311participants aged 45-74 years (mean: 56.5 years). A latent class analysis of items from the Center for Epidemiological Studies for Depression scale and the Spielberger Trait Anxiety Inventory was used to derive an anxious depression construct. Neurocognitive measures included scores on the Brief Spanish English Verbal Learning Test (B-SEVLT, learning and recall trials), Word Fluency (WF), Digit Symbol Substitution (DSS) test, and a Global Cognitive Score (GCS). We fit survey linear regression models to test the associations between anxious depression symptomatology and cognitive function. We tested for effect modification by sex, Hispanic heritage, and age groups. Results: Among men, 71.6{\%} reported low, 23.3{\%} moderate, and 5.1{\%} high ADS. Among women, 55.1{\%} reported low, 33.2{\%} moderate, and 11.8{\%} high ADS. After controlling for age, sex, sociodemographic characteristics, cardiovascular risk factors and disease, and antidepressant use, we found significant inverse associations between moderate and high anxious depression (ref:low) with B-SEVLT learning and recall, DSS and GCS. Moderate, but not high, anxious depression was inversely associated with WF. Associations were not modified by sex, Hispanic heritage, or age. Conclusions: Increased anxious depression symptomatology is associated with decreased neurocognitive function among Hispanics. Longitudinal studies are needed to establish temporality and infer if negative emotional symptoms precede cognitive deficits.",
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AU - Tarraf, Wassim

AU - Jimenez, Daniel E.

AU - Gallo, Linda C.

AU - Gonzalez, Patricia

AU - Kaplan, Robert C.

AU - Lamar, Melissa

AU - Khambaty, Tasneem

AU - Thyagarajan, Bharat

AU - Perreira, Krista M.

AU - Hernandez, Rosalba

AU - Cai, Jianwen

AU - Daviglus, Martha L.

AU - Wassertheil-Smoller, Sylvia

AU - González, Hector M.

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