Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes

Ilkay Aksu, Mehmet Ates, Basak Baykara, Muge Kiray, Ali Riza Sisman, Erkan Buyuk, Burak Baykara, Caner Cetinkaya, Hikmet Gumus, Nazan Uysal

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

It is well known that diabetes mellitus may cause neuropsychiatric disorders such as anxiety disorders. Diabetes may also cause reduced IGF-1 (insulin like growth factor-1) levels in brain and blood. The purpose of the present study was to investigate the relationship between diabetes induced anxiety and IGF-1 levels in diabetic rats. The anxiety levels of rats were assessed 2 weeks after intraperitoneal injection of streptozotocin. Diabetic rats had higher levels of anxiety, as they spent more time in closed branches in elevated-plus-maze-test and less time in the center cells of open-field-arena. Prefrontal cortex (PFC) IGF-1 levels and neuron numbers were decreased and apoptosis was increased in diabetic rats. Blood IGF-1 levels decreased in a time dependent fashion following streptozotocin injection while blood corticosterone levels increased. They had higher malondialdehyde levels and lower superoxide dismutase enzyme activity. Oxidative stress may negatively affect blood and PFC tissue IGF-1 levels. Reduction in IGF-1 may cause PFC damage, which may eventually trigger anxiety in diabetic rats. Therapeutic strategies that increase blood and brain tissue IGF-1 levels may be promising to prevent psychiatric sequelae of diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalNeuroscience Letters
Volume531
Issue number2
DOIs
StatePublished - Dec 7 2012

Fingerprint

Experimental Diabetes Mellitus
Somatomedins
Prefrontal Cortex
Anxiety
Streptozocin
Diabetes Mellitus
Brain
Corticosterone
Anxiety Disorders
Intraperitoneal Injections
Malondialdehyde
Superoxide Dismutase
Psychiatry
Oxidative Stress
Apoptosis
Neurons
Injections
Enzymes

Keywords

  • Anxiety
  • Corticosterone
  • Diabetes
  • IGF-1
  • MDA
  • Prefrontal cortex
  • SOD

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes. / Aksu, Ilkay; Ates, Mehmet; Baykara, Basak; Kiray, Muge; Sisman, Ali Riza; Buyuk, Erkan; Baykara, Burak; Cetinkaya, Caner; Gumus, Hikmet; Uysal, Nazan.

In: Neuroscience Letters, Vol. 531, No. 2, 07.12.2012, p. 176-181.

Research output: Contribution to journalArticle

Aksu, I, Ates, M, Baykara, B, Kiray, M, Sisman, AR, Buyuk, E, Baykara, B, Cetinkaya, C, Gumus, H & Uysal, N 2012, 'Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes', Neuroscience Letters, vol. 531, no. 2, pp. 176-181. https://doi.org/10.1016/j.neulet.2012.10.045
Aksu, Ilkay ; Ates, Mehmet ; Baykara, Basak ; Kiray, Muge ; Sisman, Ali Riza ; Buyuk, Erkan ; Baykara, Burak ; Cetinkaya, Caner ; Gumus, Hikmet ; Uysal, Nazan. / Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes. In: Neuroscience Letters. 2012 ; Vol. 531, No. 2. pp. 176-181.
@article{cfd395327860477e8a16111693314ae1,
title = "Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes",
abstract = "It is well known that diabetes mellitus may cause neuropsychiatric disorders such as anxiety disorders. Diabetes may also cause reduced IGF-1 (insulin like growth factor-1) levels in brain and blood. The purpose of the present study was to investigate the relationship between diabetes induced anxiety and IGF-1 levels in diabetic rats. The anxiety levels of rats were assessed 2 weeks after intraperitoneal injection of streptozotocin. Diabetic rats had higher levels of anxiety, as they spent more time in closed branches in elevated-plus-maze-test and less time in the center cells of open-field-arena. Prefrontal cortex (PFC) IGF-1 levels and neuron numbers were decreased and apoptosis was increased in diabetic rats. Blood IGF-1 levels decreased in a time dependent fashion following streptozotocin injection while blood corticosterone levels increased. They had higher malondialdehyde levels and lower superoxide dismutase enzyme activity. Oxidative stress may negatively affect blood and PFC tissue IGF-1 levels. Reduction in IGF-1 may cause PFC damage, which may eventually trigger anxiety in diabetic rats. Therapeutic strategies that increase blood and brain tissue IGF-1 levels may be promising to prevent psychiatric sequelae of diabetes mellitus.",
keywords = "Anxiety, Corticosterone, Diabetes, IGF-1, MDA, Prefrontal cortex, SOD",
author = "Ilkay Aksu and Mehmet Ates and Basak Baykara and Muge Kiray and Sisman, {Ali Riza} and Erkan Buyuk and Burak Baykara and Caner Cetinkaya and Hikmet Gumus and Nazan Uysal",
year = "2012",
month = "12",
day = "7",
doi = "10.1016/j.neulet.2012.10.045",
language = "English (US)",
volume = "531",
pages = "176--181",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes

AU - Aksu, Ilkay

AU - Ates, Mehmet

AU - Baykara, Basak

AU - Kiray, Muge

AU - Sisman, Ali Riza

AU - Buyuk, Erkan

AU - Baykara, Burak

AU - Cetinkaya, Caner

AU - Gumus, Hikmet

AU - Uysal, Nazan

PY - 2012/12/7

Y1 - 2012/12/7

N2 - It is well known that diabetes mellitus may cause neuropsychiatric disorders such as anxiety disorders. Diabetes may also cause reduced IGF-1 (insulin like growth factor-1) levels in brain and blood. The purpose of the present study was to investigate the relationship between diabetes induced anxiety and IGF-1 levels in diabetic rats. The anxiety levels of rats were assessed 2 weeks after intraperitoneal injection of streptozotocin. Diabetic rats had higher levels of anxiety, as they spent more time in closed branches in elevated-plus-maze-test and less time in the center cells of open-field-arena. Prefrontal cortex (PFC) IGF-1 levels and neuron numbers were decreased and apoptosis was increased in diabetic rats. Blood IGF-1 levels decreased in a time dependent fashion following streptozotocin injection while blood corticosterone levels increased. They had higher malondialdehyde levels and lower superoxide dismutase enzyme activity. Oxidative stress may negatively affect blood and PFC tissue IGF-1 levels. Reduction in IGF-1 may cause PFC damage, which may eventually trigger anxiety in diabetic rats. Therapeutic strategies that increase blood and brain tissue IGF-1 levels may be promising to prevent psychiatric sequelae of diabetes mellitus.

AB - It is well known that diabetes mellitus may cause neuropsychiatric disorders such as anxiety disorders. Diabetes may also cause reduced IGF-1 (insulin like growth factor-1) levels in brain and blood. The purpose of the present study was to investigate the relationship between diabetes induced anxiety and IGF-1 levels in diabetic rats. The anxiety levels of rats were assessed 2 weeks after intraperitoneal injection of streptozotocin. Diabetic rats had higher levels of anxiety, as they spent more time in closed branches in elevated-plus-maze-test and less time in the center cells of open-field-arena. Prefrontal cortex (PFC) IGF-1 levels and neuron numbers were decreased and apoptosis was increased in diabetic rats. Blood IGF-1 levels decreased in a time dependent fashion following streptozotocin injection while blood corticosterone levels increased. They had higher malondialdehyde levels and lower superoxide dismutase enzyme activity. Oxidative stress may negatively affect blood and PFC tissue IGF-1 levels. Reduction in IGF-1 may cause PFC damage, which may eventually trigger anxiety in diabetic rats. Therapeutic strategies that increase blood and brain tissue IGF-1 levels may be promising to prevent psychiatric sequelae of diabetes mellitus.

KW - Anxiety

KW - Corticosterone

KW - Diabetes

KW - IGF-1

KW - MDA

KW - Prefrontal cortex

KW - SOD

UR - http://www.scopus.com/inward/record.url?scp=84870405408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870405408&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2012.10.045

DO - 10.1016/j.neulet.2012.10.045

M3 - Article

VL - 531

SP - 176

EP - 181

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -