The effect of the antitumor fraction isolated from the α2-globulin region of normal human serum (NHG-I) upon murine (FELC) and human (K562) erythroleukemic cells in vitro was determined NHG-I inhibited the growth of both actively growing FELC and K562 cells in a dose-dependent manner. However, it had no effect upon mitomycin C treated FELC which were unable to divide nor upon dimethylsulfoxide-induced FELC in stationary phase. These results indicate that NHG-I has a cytostatic effect upon cell growth and suggests that its action may be dependent upon DNA synthesis. This is in marked contrast to TNF, the α2-globulin factor obtained from murine serum which is also not species-specific but whose action upon these cell lines is cytotoxic.
|Original language||English (US)|
|Number of pages||7|
|Journal||Experimental Cell Biology|
|Publication status||Published - Jan 1 1985|
ASJC Scopus subject areas
- Cell Biology