Antitumor activity of normal human globulin: Effects on murine and human erythroleukemic cells:

Kimita Suyama, J. Goldstein, S. Green

Research output: Contribution to journalArticle

Abstract

The effect of the antitumor fraction isolated from the α2-globulin region of normal human serum (NHG-I) upon murine (FELC) and human (K562) erythroleukemic cells in vitro was determined NHG-I inhibited the growth of both actively growing FELC and K562 cells in a dose-dependent manner. However, it had no effect upon mitomycin C treated FELC which were unable to divide nor upon dimethylsulfoxide-induced FELC in stationary phase. These results indicate that NHG-I has a cytostatic effect upon cell growth and suggests that its action may be dependent upon DNA synthesis. This is in marked contrast to TNF, the α2-globulin factor obtained from murine serum which is also not species-specific but whose action upon these cell lines is cytotoxic.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalExperimental Cell Biology
Volume53
Issue number2
StatePublished - 1985
Externally publishedYes

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K562 Cells
Globulins
Human Activities
Cytostatic Agents
Mitomycin
Growth
Dimethyl Sulfoxide
Serum
Cell Line
DNA
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology

Cite this

Antitumor activity of normal human globulin : Effects on murine and human erythroleukemic cells: / Suyama, Kimita; Goldstein, J.; Green, S.

In: Experimental Cell Biology, Vol. 53, No. 2, 1985, p. 93-99.

Research output: Contribution to journalArticle

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