Abstract
The effect of the antitumor fraction isolated from the α2-globulin region of normal human serum (NHG-I) upon murine (FELC) and human (K562) erythroleukemic cells in vitro was determined NHG-I inhibited the growth of both actively growing FELC and K562 cells in a dose-dependent manner. However, it had no effect upon mitomycin C treated FELC which were unable to divide nor upon dimethylsulfoxide-induced FELC in stationary phase. These results indicate that NHG-I has a cytostatic effect upon cell growth and suggests that its action may be dependent upon DNA synthesis. This is in marked contrast to TNF, the α2-globulin factor obtained from murine serum which is also not species-specific but whose action upon these cell lines is cytotoxic.
Original language | English (US) |
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Pages (from-to) | 93-99 |
Number of pages | 7 |
Journal | Experimental Cell Biology |
Volume | 53 |
Issue number | 2 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology