Antitumor activity of normal human globulin: Effects on murine and human erythroleukemic cells:

K. Suyama, J. Goldstein, S. Green

Research output: Contribution to journalArticle

Abstract

The effect of the antitumor fraction isolated from the α2-globulin region of normal human serum (NHG-I) upon murine (FELC) and human (K562) erythroleukemic cells in vitro was determined NHG-I inhibited the growth of both actively growing FELC and K562 cells in a dose-dependent manner. However, it had no effect upon mitomycin C treated FELC which were unable to divide nor upon dimethylsulfoxide-induced FELC in stationary phase. These results indicate that NHG-I has a cytostatic effect upon cell growth and suggests that its action may be dependent upon DNA synthesis. This is in marked contrast to TNF, the α2-globulin factor obtained from murine serum which is also not species-specific but whose action upon these cell lines is cytotoxic.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalExperimental Cell Biology
Volume53
Issue number2
Publication statusPublished - Jan 1 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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