Antiretroviral therapy in HIV-infected adolescents: clinical and pharmacologic challenges

Joanna Dobroszycki, Philip Lee, Dina L. Romo, Michael G. Rosenberg, Andrew Wiznia, Jacobo Abadi

Research output: Contribution to journalReview article

Abstract

Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.

Original languageEnglish (US)
Pages (from-to)509-516
Number of pages8
JournalExpert Review of Clinical Pharmacology
Volume10
Issue number5
DOIs
StatePublished - May 4 2017
Externally publishedYes

Fingerprint

HIV
Life Expectancy
Young Adult
Clinical Trials
Therapeutics

Keywords

  • adherence
  • Adolescents
  • antiretoviral therapy
  • HIV infection
  • HIV pharmacology
  • perinatal HIV infection

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Antiretroviral therapy in HIV-infected adolescents : clinical and pharmacologic challenges. / Dobroszycki, Joanna; Lee, Philip; Romo, Dina L.; Rosenberg, Michael G.; Wiznia, Andrew; Abadi, Jacobo.

In: Expert Review of Clinical Pharmacology, Vol. 10, No. 5, 04.05.2017, p. 509-516.

Research output: Contribution to journalReview article

Dobroszycki, Joanna ; Lee, Philip ; Romo, Dina L. ; Rosenberg, Michael G. ; Wiznia, Andrew ; Abadi, Jacobo. / Antiretroviral therapy in HIV-infected adolescents : clinical and pharmacologic challenges. In: Expert Review of Clinical Pharmacology. 2017 ; Vol. 10, No. 5. pp. 509-516.
@article{8ef0b55a4d804fe19768071c09322722,
title = "Antiretroviral therapy in HIV-infected adolescents: clinical and pharmacologic challenges",
abstract = "Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.",
keywords = "adherence, Adolescents, antiretoviral therapy, HIV infection, HIV pharmacology, perinatal HIV infection",
author = "Joanna Dobroszycki and Philip Lee and Romo, {Dina L.} and Rosenberg, {Michael G.} and Andrew Wiznia and Jacobo Abadi",
year = "2017",
month = "5",
day = "4",
doi = "10.1080/17512433.2017.1301205",
language = "English (US)",
volume = "10",
pages = "509--516",
journal = "Expert Review of Clinical Pharmacology",
issn = "1751-2433",
publisher = "Expert Reviews Ltd.",
number = "5",

}

TY - JOUR

T1 - Antiretroviral therapy in HIV-infected adolescents

T2 - clinical and pharmacologic challenges

AU - Dobroszycki, Joanna

AU - Lee, Philip

AU - Romo, Dina L.

AU - Rosenberg, Michael G.

AU - Wiznia, Andrew

AU - Abadi, Jacobo

PY - 2017/5/4

Y1 - 2017/5/4

N2 - Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.

AB - Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.

KW - adherence

KW - Adolescents

KW - antiretoviral therapy

KW - HIV infection

KW - HIV pharmacology

KW - perinatal HIV infection

UR - http://www.scopus.com/inward/record.url?scp=85018694266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018694266&partnerID=8YFLogxK

U2 - 10.1080/17512433.2017.1301205

DO - 10.1080/17512433.2017.1301205

M3 - Review article

C2 - 28288535

AN - SCOPUS:85018694266

VL - 10

SP - 509

EP - 516

JO - Expert Review of Clinical Pharmacology

JF - Expert Review of Clinical Pharmacology

SN - 1751-2433

IS - 5

ER -