TY - JOUR
T1 - Antiretroviral therapy in HIV-infected adolescents
T2 - clinical and pharmacologic challenges
AU - Dobroszycki, Joanna
AU - Lee, Philip
AU - Romo, Dina L.
AU - Rosenberg, Michael G.
AU - Wiznia, Andrew
AU - Abadi, Jacobo
PY - 2017/5/4
Y1 - 2017/5/4
N2 - Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.
AB - Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.
KW - adherence
KW - Adolescents
KW - antiretoviral therapy
KW - HIV infection
KW - HIV pharmacology
KW - perinatal HIV infection
UR - http://www.scopus.com/inward/record.url?scp=85018694266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018694266&partnerID=8YFLogxK
U2 - 10.1080/17512433.2017.1301205
DO - 10.1080/17512433.2017.1301205
M3 - Review article
C2 - 28288535
AN - SCOPUS:85018694266
SN - 1751-2433
VL - 10
SP - 509
EP - 516
JO - Expert Review of Clinical Pharmacology
JF - Expert Review of Clinical Pharmacology
IS - 5
ER -
