Antiretroviral therapy in HIV-infected adolescents: clinical and pharmacologic challenges

Joanna Dobroszycki, Philip Lee, Dina L. Romo, Michael G. Rosenberg, Andrew Wiznia, Jacobo Abadi

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Introduction: With the currently available combined antiretroviral therapy regimens, durable suppression of viral replication, preservation of immune function and normalizing life expectancy, are all becoming achievable goals. Teenagers and young adults living with HIV present unique clinical and pharmacologic challenges to optimizing antiretroviral treatment outcomes. Areas covered: In this expert review of the topic, we examine recent clinical trial data and draw on our program’s 25 year experience working with both perinatally and behaviorally HIV infected adolescents. Expert commentary: In order to be effective, the antiretrovirals we provide must be combined with multidisciplinary interventions and ongoing socio-behavioral support to ensure treatment adherence and prevent the emergence of viral resistance.

Original languageEnglish (US)
Pages (from-to)509-516
Number of pages8
JournalExpert Review of Clinical Pharmacology
Volume10
Issue number5
DOIs
StatePublished - May 4 2017
Externally publishedYes

Keywords

  • adherence
  • Adolescents
  • antiretoviral therapy
  • HIV infection
  • HIV pharmacology
  • perinatal HIV infection

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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