Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy

Inmaculada Tasset, René Drucker-Colín, José Peña, Ignacio Jimena, Pedro Montilla, Francisco Javier Medina, Isaac Túnez

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.

Original languageEnglish (US)
Pages (from-to)1182-1187
Number of pages6
JournalNeurochemical Research
Volume35
Issue number8
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Oxidative stress
Transcranial Magnetic Stimulation
Oxidative Stress
Antioxidants
Cytoprotection
Enzyme activity
Biomarkers
Caspase 3
Lipid Peroxidation
Glutathione
Wistar Rats
Rats
Cells
Apoptosis
Lipids
Enzymes
Therapeutics

Keywords

  • Antidepressive
  • Anxiety
  • Apoptosis
  • Cell death
  • Oxidative stress
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy. / Tasset, Inmaculada; Drucker-Colín, René; Peña, José; Jimena, Ignacio; Montilla, Pedro; Medina, Francisco Javier; Túnez, Isaac.

In: Neurochemical Research, Vol. 35, No. 8, 08.2010, p. 1182-1187.

Research output: Contribution to journalArticle

Tasset, Inmaculada ; Drucker-Colín, René ; Peña, José ; Jimena, Ignacio ; Montilla, Pedro ; Medina, Francisco Javier ; Túnez, Isaac. / Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy. In: Neurochemical Research. 2010 ; Vol. 35, No. 8. pp. 1182-1187.
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