Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy

Inmaculada Tasset, René Drucker-Colín, José Peña, Ignacio Jimena, Pedro Montilla, Francisco Javier Medina, Isaac Túnez

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.

Original languageEnglish (US)
Pages (from-to)1182-1187
Number of pages6
JournalNeurochemical Research
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

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Keywords

  • Antidepressive
  • Anxiety
  • Apoptosis
  • Cell death
  • Oxidative stress
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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