Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against staphylococcus aureus skin infection

Luis R. Martinez, George Han, Manju Chacko, Mircea Radu Mihu, Marc Jacobson, Philip Gialanella, Adam J. Friedman, Joshua D. Nosanchuk, Joel M. Friedman

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Staphylococcus aureus (SA) is a leading cause of both superficial and invasive infections in community and hospital settings, frequently resulting in chronic refractory disease. It is imperative that innovative therapeutics to which the bacteria are unlikely to evolve resistance be developed to curtail associated morbidity and mortality and ultimately improve our capacity to treat these infections. In this study, a previously unreported nitric oxide (NO)-releasing nanoparticle technology is applied to the treatment of methicillin-resistant SA (MRSA) wound infections. The results show that the nanoparticles exert antimicrobial activity against MRSA in a murine wound model. Acceleration of infected wound closure in NO-treated groups was clinically shown compared with controls. The histology of wounds revealed that NO nanoparticle treatment decreased suppurative inflammation, minimal bacterial burden, and less collagen degradation, providing potential mechanisms for biological activity. Together, these data suggest that these NO-releasing nanoparticles have the potential to serve as a novel class of topically applied antimicrobials for the treatment of cutaneous infections and wounds.

Original languageEnglish (US)
Pages (from-to)2463-2469
Number of pages7
JournalJournal of Investigative Dermatology
Volume129
Issue number10
DOIs
StatePublished - Oct 2009

Fingerprint

Nanoparticles
Staphylococcus aureus
Skin
Nitric Oxide
Methicillin
Wound Infection
Infection
Wounds and Injuries
Methicillin Resistance
Histology
Community Hospital
Therapeutics
Methicillin-Resistant Staphylococcus aureus
Bioactivity
Refractory materials
Bacteria
Chronic Disease
Collagen
Inflammation
Technology

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against staphylococcus aureus skin infection. / Martinez, Luis R.; Han, George; Chacko, Manju; Mihu, Mircea Radu; Jacobson, Marc; Gialanella, Philip; Friedman, Adam J.; Nosanchuk, Joshua D.; Friedman, Joel M.

In: Journal of Investigative Dermatology, Vol. 129, No. 10, 10.2009, p. 2463-2469.

Research output: Contribution to journalArticle

Martinez, Luis R. ; Han, George ; Chacko, Manju ; Mihu, Mircea Radu ; Jacobson, Marc ; Gialanella, Philip ; Friedman, Adam J. ; Nosanchuk, Joshua D. ; Friedman, Joel M. / Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against staphylococcus aureus skin infection. In: Journal of Investigative Dermatology. 2009 ; Vol. 129, No. 10. pp. 2463-2469.
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