Antimetabolites: A new perspective

Peter D. Cole, John A. Zebala, Barton A. Kamen

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Antimetabolites remain as mainstays in our chemotherapeutic armamentarium. Recent approval of several nucleoside analogs and antifolates serve to highlight the progress made in the past 60 years but more importantly their pharmacology/biochemistry reminds us of the complexity of the pathways involved. Antimetabolites should be considered as specific targeting agents in the emerging arena of metabolomics and as tools to more completely understand cellular metabolism.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalDrug Discovery Today: Therapeutic Strategies
Volume2
Issue number4
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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