Antimalarial drug therapy

The role of parasite biology and drug resistance

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Malaria continues to affect public health and economic growth in many regions of the world. The number of infections continues to rise and is associated with increased mortality, despite basic science and public health efforts. Drug therapy remains the mainstay of treatment and prevention of this disease. Plasmodium has a complex life cycle involving an arthropod vector and distinct stages within the human host. Each parasite stage plays a unique role in transmission, disease, and latency. These different stages may vary in their response to the various antimalarial compounds. This article will review antimalarial therapies and drug resistance in the context of the parasites' biology.

Original languageEnglish (US)
Pages (from-to)1487-1497
Number of pages11
JournalJournal of Clinical Pharmacology
Volume46
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Antimalarials
Drug Resistance
Parasites
Public Health
Arthropod Vectors
Drug Therapy
Plasmodium
Economic Development
Life Cycle Stages
Malaria
Mortality
Therapeutics
Infection

Keywords

  • Antimalarial therapy
  • Drug resistance
  • Plasmodium
  • Review

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Antimalarial drug therapy : The role of parasite biology and drug resistance. / Daily, Johanna P.

In: Journal of Clinical Pharmacology, Vol. 46, No. 12, 12.2006, p. 1487-1497.

Research output: Contribution to journalArticle

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