Antihelper T cell autoantibody in acquired agammaglobulinemia

Arye Rubinstein, M. Sicklick, V. Mehra, F. S. Rosen, R. H. Levey

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH 2 -T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH 2 +Ia + T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cell. Conversely, total thymectomy resulted in a temporary disappearance of the TH 2 +Ia + suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalJournal of Clinical Investigation
Volume67
Issue number1
StatePublished - 1981

Fingerprint

Agammaglobulinemia
Autoantibodies
Helper-Inducer T-Lymphocytes
T-Lymphocytes
TCF Transcription Factors
Lymphocytosis
Thymectomy
Th2 Cells
Plasmapheresis
Immunoglobulin Isotypes
T-Lymphocyte Subsets
Immunoglobulin G
Antibodies
Population
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rubinstein, A., Sicklick, M., Mehra, V., Rosen, F. S., & Levey, R. H. (1981). Antihelper T cell autoantibody in acquired agammaglobulinemia. Journal of Clinical Investigation, 67(1), 42-50.

Antihelper T cell autoantibody in acquired agammaglobulinemia. / Rubinstein, Arye; Sicklick, M.; Mehra, V.; Rosen, F. S.; Levey, R. H.

In: Journal of Clinical Investigation, Vol. 67, No. 1, 1981, p. 42-50.

Research output: Contribution to journalArticle

Rubinstein, A, Sicklick, M, Mehra, V, Rosen, FS & Levey, RH 1981, 'Antihelper T cell autoantibody in acquired agammaglobulinemia', Journal of Clinical Investigation, vol. 67, no. 1, pp. 42-50.
Rubinstein, Arye ; Sicklick, M. ; Mehra, V. ; Rosen, F. S. ; Levey, R. H. / Antihelper T cell autoantibody in acquired agammaglobulinemia. In: Journal of Clinical Investigation. 1981 ; Vol. 67, No. 1. pp. 42-50.
@article{86fc256de30b497480de8df5c6535f36,
title = "Antihelper T cell autoantibody in acquired agammaglobulinemia",
abstract = "A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH 2 -T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH 2 +Ia + T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cell. Conversely, total thymectomy resulted in a temporary disappearance of the TH 2 +Ia + suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.",
author = "Arye Rubinstein and M. Sicklick and V. Mehra and Rosen, {F. S.} and Levey, {R. H.}",
year = "1981",
language = "English (US)",
volume = "67",
pages = "42--50",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "1",

}

TY - JOUR

T1 - Antihelper T cell autoantibody in acquired agammaglobulinemia

AU - Rubinstein, Arye

AU - Sicklick, M.

AU - Mehra, V.

AU - Rosen, F. S.

AU - Levey, R. H.

PY - 1981

Y1 - 1981

N2 - A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH 2 -T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH 2 +Ia + T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cell. Conversely, total thymectomy resulted in a temporary disappearance of the TH 2 +Ia + suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.

AB - A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH 2 -T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH 2 +Ia + T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cell. Conversely, total thymectomy resulted in a temporary disappearance of the TH 2 +Ia + suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.

UR - http://www.scopus.com/inward/record.url?scp=0019434856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019434856&partnerID=8YFLogxK

M3 - Article

C2 - 6450224

AN - SCOPUS:0019434856

VL - 67

SP - 42

EP - 50

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 1

ER -