Abstract
It is now well demonstrated that the repertoire of T cells includes not only cells that recognize specific MHC-presented peptide antigens, but also cells that recognize specific self and foreign lipid antigens. This T cell recognition of lipid antigens is mediated by a family of conserved MHC class I-like cell surface glycoproteins known as CD1 molecules. These are specialized antigen-presenting molecules that directly bind a wide variety of lipids and present them for T cell recognition at the surface of antigen-presenting cells. Distinct populations of T cells exist that recognize CD1-presented lipids of microbial, environmental or self origin, and these T cells participate in immune responses associated with infectious, neoplastic, autoimmune and allergic diseases. Here we review the current knowledge of the biology of the CD1 system, including the structure, biosynthesis and trafficking of CD1 molecules, the structures of defined lipid antigens and the types of functional responses mediated by T cells specific for CD1-presented lipids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1824-1840 |
| Number of pages | 17 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 64 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 2007 |
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Keywords
- Adaptive immunity
- Antigen presentation
- CD1
- Galactosylceramide
- Glycolipid
- Lipid
- Phospholipid
- T cell
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
Antigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity. / Bricard, G.; Porcelli, Steven A.
In: Cellular and Molecular Life Sciences, Vol. 64, No. 14, 07.2007, p. 1824-1840.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity
AU - Bricard, G.
AU - Porcelli, Steven A.
PY - 2007/7
Y1 - 2007/7
N2 - It is now well demonstrated that the repertoire of T cells includes not only cells that recognize specific MHC-presented peptide antigens, but also cells that recognize specific self and foreign lipid antigens. This T cell recognition of lipid antigens is mediated by a family of conserved MHC class I-like cell surface glycoproteins known as CD1 molecules. These are specialized antigen-presenting molecules that directly bind a wide variety of lipids and present them for T cell recognition at the surface of antigen-presenting cells. Distinct populations of T cells exist that recognize CD1-presented lipids of microbial, environmental or self origin, and these T cells participate in immune responses associated with infectious, neoplastic, autoimmune and allergic diseases. Here we review the current knowledge of the biology of the CD1 system, including the structure, biosynthesis and trafficking of CD1 molecules, the structures of defined lipid antigens and the types of functional responses mediated by T cells specific for CD1-presented lipids.
AB - It is now well demonstrated that the repertoire of T cells includes not only cells that recognize specific MHC-presented peptide antigens, but also cells that recognize specific self and foreign lipid antigens. This T cell recognition of lipid antigens is mediated by a family of conserved MHC class I-like cell surface glycoproteins known as CD1 molecules. These are specialized antigen-presenting molecules that directly bind a wide variety of lipids and present them for T cell recognition at the surface of antigen-presenting cells. Distinct populations of T cells exist that recognize CD1-presented lipids of microbial, environmental or self origin, and these T cells participate in immune responses associated with infectious, neoplastic, autoimmune and allergic diseases. Here we review the current knowledge of the biology of the CD1 system, including the structure, biosynthesis and trafficking of CD1 molecules, the structures of defined lipid antigens and the types of functional responses mediated by T cells specific for CD1-presented lipids.
KW - Adaptive immunity
KW - Antigen presentation
KW - CD1
KW - Galactosylceramide
KW - Glycolipid
KW - Lipid
KW - Phospholipid
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=34447644925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447644925&partnerID=8YFLogxK
U2 - 10.1007/s00018-007-7007-0
DO - 10.1007/s00018-007-7007-0
M3 - Article
C2 - 17483872
AN - SCOPUS:34447644925
VL - 64
SP - 1824
EP - 1840
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 14
ER -