Antigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity

G. Bricard, Steven A. Porcelli

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

It is now well demonstrated that the repertoire of T cells includes not only cells that recognize specific MHC-presented peptide antigens, but also cells that recognize specific self and foreign lipid antigens. This T cell recognition of lipid antigens is mediated by a family of conserved MHC class I-like cell surface glycoproteins known as CD1 molecules. These are specialized antigen-presenting molecules that directly bind a wide variety of lipids and present them for T cell recognition at the surface of antigen-presenting cells. Distinct populations of T cells exist that recognize CD1-presented lipids of microbial, environmental or self origin, and these T cells participate in immune responses associated with infectious, neoplastic, autoimmune and allergic diseases. Here we review the current knowledge of the biology of the CD1 system, including the structure, biosynthesis and trafficking of CD1 molecules, the structures of defined lipid antigens and the types of functional responses mediated by T cells specific for CD1-presented lipids.

Original languageEnglish (US)
Pages (from-to)1824-1840
Number of pages17
JournalCellular and Molecular Life Sciences
Volume64
Issue number14
DOIs
StatePublished - Jul 2007

Fingerprint

CD1 Antigens
T-cells
Antigen Presentation
Immunity
T-Lymphocytes
Lipids
Molecules
Antigens
Systems Biology
Biosynthesis
Membrane Glycoproteins
Antigen-Presenting Cells
Surface Antigens
Autoimmune Diseases
Peptides

Keywords

  • Adaptive immunity
  • Antigen presentation
  • CD1
  • Galactosylceramide
  • Glycolipid
  • Lipid
  • Phospholipid
  • T cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Antigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity. / Bricard, G.; Porcelli, Steven A.

In: Cellular and Molecular Life Sciences, Vol. 64, No. 14, 07.2007, p. 1824-1840.

Research output: Contribution to journalArticle

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