Antigen presentation by CD1 and MHC-encoded class I-like molecules

Agustín Melián; Evan M. Beckman; Steven A. Porcelli; Michael B. Brenner

doi:10.1016/S0952-7915(96)80109-9

Antigen presentation by CD1 and MHC-encoded class I-like molecules

Agustín Melián, Evan M. Beckman, Steven A. Porcelli, Michael B. Brenner

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class II molecules present peptides derived from the proteolysis of extracellular pathogens and CD1 molecules present unique microbial lipids and glycolipids. Recent studies have indicated that CD1 molecules mediate a novel system of antigen presentation and that MHC-encoded class I-like molecules can present unique subsets of intracellularly derived peptides.

Original language	English (US)
Pages (from-to)	82-88
Number of pages	7
Journal	Current Opinion in Immunology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S0952-7915(96)80109-9
State	Published - Feb 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(96)80109-9

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title = "Antigen presentation by CD1 and MHC-encoded class I-like molecules",

abstract = "Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class II molecules present peptides derived from the proteolysis of extracellular pathogens and CD1 molecules present unique microbial lipids and glycolipids. Recent studies have indicated that CD1 molecules mediate a novel system of antigen presentation and that MHC-encoded class I-like molecules can present unique subsets of intracellularly derived peptides.",

author = "Agust{\'i}n Meli{\'a}n and Beckman, {Evan M.} and Porcelli, {Steven A.} and Brenner, {Michael B.}",

note = "Funding Information: This work was funded by the National Institutes of Health, the Arthritis Foundation, the Leukemia Society and the Bugher/AHA Foundation. The authors wish to thank CT Morita and DB Moody for critically reviewing the manuscript. The authors also wish to acknowledge M Sugita, JP Rosatt, S Furlong, F Spada, R Jackman, PA Selling and RL Modlin for generously sharing unpublished data.",

year = "1996",

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doi = "10.1016/S0952-7915(96)80109-9",

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AU - Porcelli, Steven A.

AU - Brenner, Michael B.

N1 - Funding Information: This work was funded by the National Institutes of Health, the Arthritis Foundation, the Leukemia Society and the Bugher/AHA Foundation. The authors wish to thank CT Morita and DB Moody for critically reviewing the manuscript. The authors also wish to acknowledge M Sugita, JP Rosatt, S Furlong, F Spada, R Jackman, PA Selling and RL Modlin for generously sharing unpublished data.

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AB - Three known lineages of antigen-presenting molecules restrict T-cell responses to microbial antigens: MHC class I and MHC encoded class I like molecules present peptides derived from the proteolysis of intracellular pathogens, MHC class II molecules present peptides derived from the proteolysis of extracellular pathogens and CD1 molecules present unique microbial lipids and glycolipids. Recent studies have indicated that CD1 molecules mediate a novel system of antigen presentation and that MHC-encoded class I-like molecules can present unique subsets of intracellularly derived peptides.

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Antigen presentation by CD1 and MHC-encoded class I-like molecules

Abstract

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