Anticonvulsant-induced lymphoma

Marvin P. Fried, Young Sunwoo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients with cervical adenopathy of obscure etiology may present a diagnostic problem to the otolaryngologist. The hydantoin family of anticonvulsants is a rare cause of adenopathy that may range from histologically simple lymphoid hyperplasia to true lymphoma. Between these two extremes is a benign clinical entity with the histologic characteristics of lymphoma. A patient on diphenylhydantoin (Dilantin) therapy developed bilateral true vocal cord paralysis and cervical adenopathy. On pathological examination the lesion was interpreted first as malignant lymphoma and later as hydantoin-induced pseudolymphoma. He has now been followed for over two years. Hydantoin-induced adenopathy may vary clinically from a benign condition to a true lymphoma. The malignant form may present long after the anticonvulsant treatment is discontinued. A 10-fold increase in the expected incidence of malignant lymphoma in epileptic patients on hydantoin therapy has been reported; therefore, these patients required long-term follow-up. The otolaryngologist should be aware of this rare clinical entity as an unusual cause of cervical adenopathy associated with vocal cord paralysis.

Original languageEnglish (US)
Pages (from-to)1770-1781
Number of pages12
JournalLaryngoscope
Volume85
Issue number10
StatePublished - 1975
Externally publishedYes

Fingerprint

Hydantoins
Anticonvulsants
Lymphoma
Vocal Cord Paralysis
Pseudolymphoma
Phenytoin
Hyperplasia
Therapeutics
Lymphadenopathy
Incidence
Otolaryngologists

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Fried, M. P., & Sunwoo, Y. (1975). Anticonvulsant-induced lymphoma. Laryngoscope, 85(10), 1770-1781.

Anticonvulsant-induced lymphoma. / Fried, Marvin P.; Sunwoo, Young.

In: Laryngoscope, Vol. 85, No. 10, 1975, p. 1770-1781.

Research output: Contribution to journalArticle

Fried, MP & Sunwoo, Y 1975, 'Anticonvulsant-induced lymphoma', Laryngoscope, vol. 85, no. 10, pp. 1770-1781.
Fried MP, Sunwoo Y. Anticonvulsant-induced lymphoma. Laryngoscope. 1975;85(10):1770-1781.
Fried, Marvin P. ; Sunwoo, Young. / Anticonvulsant-induced lymphoma. In: Laryngoscope. 1975 ; Vol. 85, No. 10. pp. 1770-1781.
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