Antibody-mediated regulation of cellular immunity and the inflammatory response

Arturo Casadevall, Liise-anne Pirofski

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

For many pathogens the role of antibody-mediated immunity (AMI) is poorly understood, in part because of the limited tools available to establish antibody efficacy. AMI is classically associated with opsonization, toxin and viral neutralization, complement fixation and antibody-dependent cellular cytotoxicity. However, recent studies indicate new functions for AMI ranging from direct antimicrobial action to modulation of the inflammatory response. The efficacy of AMI against some pathogens is dependent on cell-mediated immunity. A new interpretation of the role of AMI is proposed whereby it is in proinflammatory the early stages of infection and anti-inflammatory at later stages of the host-microbe interaction and in the setting of established immunity and/or in an immune individual.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalTrends in Immunology
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2003

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Cellular Immunity
Immunity
Antibodies
Anti-Inflammatory Agents
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Antibody-mediated regulation of cellular immunity and the inflammatory response. / Casadevall, Arturo; Pirofski, Liise-anne.

In: Trends in Immunology, Vol. 24, No. 9, 01.09.2003, p. 474-478.

Research output: Contribution to journalArticle

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