Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi, Antonio Nakouzi, Leandro J. Carreño, Magdalena Slosar-Cheah, Mark H. Kuniholm, Tao Wang, Peter G. Pappas, Liise Anne Pirofski

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

Original languageEnglish (US)
Article numberofx255
JournalOpen Forum Infectious Diseases
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • B cell subsets
  • Cryptococcus neoformans
  • HIV-associated cryptococcosis
  • antibody immunity
  • memory B cells

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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