@article{c85142cd56a14abc8bb748142a95bf36,
title = "Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis",
abstract = "The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.",
keywords = "B cell subsets, Cryptococcus neoformans, HIV-associated cryptococcosis, antibody immunity, memory B cells",
author = "Soma Rohatgi and Antonio Nakouzi and Carre{\~n}o, {Leandro J.} and Magdalena Slosar-Cheah and Kuniholm, {Mark H.} and Tao Wang and Pappas, {Peter G.} and Pirofski, {Liise Anne}",
note = "Funding Information: Potential conflicts of interest. P. G. P. reports the following: grants from Merck, Gilead, IMMY, Cidara, Scynexis, Astellas; consultant for Viamet, Vical, Matinas, Gilead, Scynexis, IMMY, and Mayne Pharma. The IMMY LFA was performed on samples collected for the study with kits obtained from the Montefiore Microbiology laboratory, where the assay is used for determining cryptococcal antigen levels. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Funding Information: Financial support. This work was funded by a National Institutes of Health grant R01AI97096 (to L. P.). Publisher Copyright: {\textcopyright} The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2018",
month = jan,
day = "1",
doi = "10.1093/ofid/ofx255",
language = "English (US)",
volume = "5",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "1",
}
