Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi; Antonio Nakouzi; Leandro J. Carreño; Magdalena Slosar-Cheah; Mark H. Kuniholm; Tao Wang; Peter G. Pappas; Liise Anne Pirofski

doi:10.1093/ofid/ofx255

Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi, Antonio Nakouzi, Leandro J. Carreño, Magdalena Slosar-Cheah, Mark H. Kuniholm, Tao Wang, Peter G. Pappas, Liise Anne Pirofski

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

Original language	English (US)
Article number	ofx255
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofx255
State	Published - Jan 1 2018

Keywords

B cell subsets
Cryptococcus neoformans
HIV-associated cryptococcosis
antibody immunity
memory B cells

ASJC Scopus subject areas

Infectious Diseases
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofx255

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title = "Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis",

abstract = "The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.",

keywords = "B cell subsets, Cryptococcus neoformans, HIV-associated cryptococcosis, antibody immunity, memory B cells",

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AU - Nakouzi, Antonio

AU - Carreño, Leandro J.

AU - Slosar-Cheah, Magdalena

AU - Kuniholm, Mark H.

AU - Wang, Tao

AU - Pappas, Peter G.

AU - Pirofski, Liise Anne

N1 - Publisher Copyright: © The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

AB - The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

KW - B cell subsets

KW - Cryptococcus neoformans

KW - HIV-associated cryptococcosis

KW - antibody immunity

KW - memory B cells

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Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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