Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi; Antonio Nakouzi; Leandro J. Carreño; Magdalena Slosar-Cheah; Mark H. Kuniholm; Tao Wang; Peter G. Pappas; Liise Anne Pirofski

doi:10.1093/ofid/ofx255

Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi, Antonio Nakouzi, Leandro J. Carreño, Magdalena Slosar-Cheah, Mark H. Kuniholm, Tao Wang, Peter G. Pappas, Liise Anne Pirofski

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

Original language	English (US)
Article number	ofx255
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofx255
Publication status	Published - Jan 1 2018

Fingerprint

Keywords

B cell subsets
Cryptococcus neoformans
HIV-associated cryptococcosis
antibody immunity
memory B cells

ASJC Scopus subject areas

Oncology
Clinical Neurology

Cite this

Rohatgi, S., Nakouzi, A., Carreño, L. J., Slosar-Cheah, M., Kuniholm, M. H., Wang, T., ... Pirofski, L. A. (2018). Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis. Open Forum Infectious Diseases, 5(1), [ofx255]. https://doi.org/10.1093/ofid/ofx255

Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis. / Rohatgi, Soma; Nakouzi, Antonio; Carreño, Leandro J.; Slosar-Cheah, Magdalena; Kuniholm, Mark H.; Wang, Tao; Pappas, Peter G.; Pirofski, Liise Anne.

In: Open Forum Infectious Diseases, Vol. 5, No. 1, ofx255, 01.01.2018.

Research output: Contribution to journal › Article

@article{c85142cd56a14abc8bb748142a95bf36,

title = "Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis",

abstract = "The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.",

keywords = "B cell subsets, Cryptococcus neoformans, HIV-associated cryptococcosis, antibody immunity, memory B cells",

author = "Soma Rohatgi and Antonio Nakouzi and Carre{\~n}o, {Leandro J.} and Magdalena Slosar-Cheah and Kuniholm, {Mark H.} and Tao Wang and Pappas, {Peter G.} and Pirofski, {Liise Anne}",

year = "2018",

month = "1",

day = "1",

doi = "10.1093/ofid/ofx255",

language = "English (US)",

volume = "5",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

AU - Rohatgi, Soma

AU - Nakouzi, Antonio

AU - Carreño, Leandro J.

AU - Slosar-Cheah, Magdalena

AU - Kuniholm, Mark H.

AU - Wang, Tao

AU - Pappas, Peter G.

AU - Pirofski, Liise Anne

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

AB - The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

KW - B cell subsets

KW - Cryptococcus neoformans

KW - HIV-associated cryptococcosis

KW - antibody immunity

KW - memory B cells

UR - http://www.scopus.com/inward/record.url?scp=85054406024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054406024&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofx255

DO - 10.1093/ofid/ofx255

M3 - Article

AN - SCOPUS:85054406024

VL - 5

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

SN - 2328-8957

IS - 1

M1 - ofx255

ER -

Access to Document

10.1093/ofid/ofx255