Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi; Antonio Nakouzi; Leandro J. Carreño; Magdalena Slosar-Cheah; Mark H. Kuniholm; Tao Wang; Peter G. Pappas; Liise Anne Pirofski

doi:10.1093/ofid/ofx255

Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Soma Rohatgi, Antonio Nakouzi, Leandro J. Carreño, Magdalena Slosar-Cheah, Mark H. Kuniholm, Tao Wang, Peter G. Pappas, Liise Anne Pirofski

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

Original language	English (US)
Article number	ofx255
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofx255
State	Published - Jan 1 2018

Keywords

B cell subsets
Cryptococcus neoformans
HIV-associated cryptococcosis
antibody immunity
memory B cells

ASJC Scopus subject areas

Oncology
Clinical Neurology

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10.1093/ofid/ofx255

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Rohatgi, S., Nakouzi, A., Carreño, L. J., Slosar-Cheah, M., Kuniholm, M. H., Wang, T., Pappas, P. G., & Pirofski, L. A. (2018). Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis. Open Forum Infectious Diseases, 5(1), [ofx255]. https://doi.org/10.1093/ofid/ofx255

Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis. / Rohatgi, Soma; Nakouzi, Antonio; Carreño, Leandro J.; Slosar-Cheah, Magdalena; Kuniholm, Mark H.; Wang, Tao; Pappas, Peter G.; Pirofski, Liise Anne.

In: Open Forum Infectious Diseases, Vol. 5, No. 1, ofx255, 01.01.2018.

Research output: Contribution to journal › Article

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