Abstract
The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.
| Original language | English (US) |
|---|---|
| Journal | Open Forum Infectious Diseases |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- antibody immunity
- B cell subsets
- Cryptococcus neoformans
- HIV-associated cryptococcosis
- memory B cells
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
Cite this
Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis. / Rohatgi, Soma; Nakouzi, Antonio; Carreño, Leandro J.; Slosar-Cheah, Magdalena; Kuniholm, Mark H.; Wang, Tao; Pappas, Peter G.; Pirofski, Liise-anne.
In: Open Forum Infectious Diseases, Vol. 5, No. 1, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis
AU - Rohatgi, Soma
AU - Nakouzi, Antonio
AU - Carreño, Leandro J.
AU - Slosar-Cheah, Magdalena
AU - Kuniholm, Mark H.
AU - Wang, Tao
AU - Pappas, Peter G.
AU - Pirofski, Liise-anne
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.
AB - The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.
KW - antibody immunity
KW - B cell subsets
KW - Cryptococcus neoformans
KW - HIV-associated cryptococcosis
KW - memory B cells
UR - http://www.scopus.com/inward/record.url?scp=85054406024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054406024&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofx255
DO - 10.1093/ofid/ofx255
M3 - Article
VL - 5
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 1
ER -