Anti-müllerian hormone and obesity

Vicky Moy, Erkan Buyuk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obesity continues to be an epidemic in the United States, negatively impacting overall morbidity and mortality, as well as reproductive outcomes. Although the effect of obesity on fertility is likely multi-faceted, obese patients exhibit an altered ovarian follicular environment that impairs steroidogenic action, folliculogenesis and metabolism, and is associated with inflammation, which may contribute to these poor outcomes. Anti-Müllerian hormone (AMH), produced by the granulosa cells of preantral and antral follicles, has been demonstrated to be a useful marker of ovarian reserve; AMH is the earliest marker to change with aging and has minimal inter- and intra-cycle variability. The relation between obesity and serum AMH levels is complex. Age, presence or absence of PCOS, the status of glucose metabolism like insulin resistance states, and potentially race may affect this interaction. The effect of weight loss on serum AMH levels is less clear. It is dependent on the above-mentioned factors, as well as the type of intervention like caloric restriction, physical activity, medical or surgical treatment. Consequently, despite the abundance of publications that study the relationship between obesity and AMH levels, the results are conflicting with lack of a consensus. Elucidation of the mechanisms of the effects of obesity states on serum AMH levels will improve our understanding of these complex interactions, potentially leading to discovery of therapies that may improve reproductive function.

Original languageEnglish (US)
Title of host publicationAnti-Müllerian Hormone
Subtitle of host publicationBiology, Role in Ovarian Function and Clinical Significance
PublisherNova Science Publishers, Inc.
Pages263-280
Number of pages18
ISBN (Electronic)9781634840170
ISBN (Print)9781634840125
StatePublished - Jan 1 2016

Fingerprint

Obesity
Hormones
Serum
Caloric Restriction
Status Epilepticus
Granulosa Cells
Fertility
Insulin Resistance
Publications
Weight Loss
Exercise
Inflammation
Morbidity
Glucose
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Moy, V., & Buyuk, E. (2016). Anti-müllerian hormone and obesity. In Anti-Müllerian Hormone: Biology, Role in Ovarian Function and Clinical Significance (pp. 263-280). Nova Science Publishers, Inc..

Anti-müllerian hormone and obesity. / Moy, Vicky; Buyuk, Erkan.

Anti-Müllerian Hormone: Biology, Role in Ovarian Function and Clinical Significance. Nova Science Publishers, Inc., 2016. p. 263-280.

Research output: Chapter in Book/Report/Conference proceedingChapter

Moy, V & Buyuk, E 2016, Anti-müllerian hormone and obesity. in Anti-Müllerian Hormone: Biology, Role in Ovarian Function and Clinical Significance. Nova Science Publishers, Inc., pp. 263-280.
Moy V, Buyuk E. Anti-müllerian hormone and obesity. In Anti-Müllerian Hormone: Biology, Role in Ovarian Function and Clinical Significance. Nova Science Publishers, Inc. 2016. p. 263-280
Moy, Vicky ; Buyuk, Erkan. / Anti-müllerian hormone and obesity. Anti-Müllerian Hormone: Biology, Role in Ovarian Function and Clinical Significance. Nova Science Publishers, Inc., 2016. pp. 263-280
@inbook{330e91db7c2749369f46fe59b82f9c07,
title = "Anti-m{\"u}llerian hormone and obesity",
abstract = "Obesity continues to be an epidemic in the United States, negatively impacting overall morbidity and mortality, as well as reproductive outcomes. Although the effect of obesity on fertility is likely multi-faceted, obese patients exhibit an altered ovarian follicular environment that impairs steroidogenic action, folliculogenesis and metabolism, and is associated with inflammation, which may contribute to these poor outcomes. Anti-M{\"u}llerian hormone (AMH), produced by the granulosa cells of preantral and antral follicles, has been demonstrated to be a useful marker of ovarian reserve; AMH is the earliest marker to change with aging and has minimal inter- and intra-cycle variability. The relation between obesity and serum AMH levels is complex. Age, presence or absence of PCOS, the status of glucose metabolism like insulin resistance states, and potentially race may affect this interaction. The effect of weight loss on serum AMH levels is less clear. It is dependent on the above-mentioned factors, as well as the type of intervention like caloric restriction, physical activity, medical or surgical treatment. Consequently, despite the abundance of publications that study the relationship between obesity and AMH levels, the results are conflicting with lack of a consensus. Elucidation of the mechanisms of the effects of obesity states on serum AMH levels will improve our understanding of these complex interactions, potentially leading to discovery of therapies that may improve reproductive function.",
author = "Vicky Moy and Erkan Buyuk",
year = "2016",
month = "1",
day = "1",
language = "English (US)",
isbn = "9781634840125",
pages = "263--280",
booktitle = "Anti-M{\"u}llerian Hormone",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Anti-müllerian hormone and obesity

AU - Moy, Vicky

AU - Buyuk, Erkan

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Obesity continues to be an epidemic in the United States, negatively impacting overall morbidity and mortality, as well as reproductive outcomes. Although the effect of obesity on fertility is likely multi-faceted, obese patients exhibit an altered ovarian follicular environment that impairs steroidogenic action, folliculogenesis and metabolism, and is associated with inflammation, which may contribute to these poor outcomes. Anti-Müllerian hormone (AMH), produced by the granulosa cells of preantral and antral follicles, has been demonstrated to be a useful marker of ovarian reserve; AMH is the earliest marker to change with aging and has minimal inter- and intra-cycle variability. The relation between obesity and serum AMH levels is complex. Age, presence or absence of PCOS, the status of glucose metabolism like insulin resistance states, and potentially race may affect this interaction. The effect of weight loss on serum AMH levels is less clear. It is dependent on the above-mentioned factors, as well as the type of intervention like caloric restriction, physical activity, medical or surgical treatment. Consequently, despite the abundance of publications that study the relationship between obesity and AMH levels, the results are conflicting with lack of a consensus. Elucidation of the mechanisms of the effects of obesity states on serum AMH levels will improve our understanding of these complex interactions, potentially leading to discovery of therapies that may improve reproductive function.

AB - Obesity continues to be an epidemic in the United States, negatively impacting overall morbidity and mortality, as well as reproductive outcomes. Although the effect of obesity on fertility is likely multi-faceted, obese patients exhibit an altered ovarian follicular environment that impairs steroidogenic action, folliculogenesis and metabolism, and is associated with inflammation, which may contribute to these poor outcomes. Anti-Müllerian hormone (AMH), produced by the granulosa cells of preantral and antral follicles, has been demonstrated to be a useful marker of ovarian reserve; AMH is the earliest marker to change with aging and has minimal inter- and intra-cycle variability. The relation between obesity and serum AMH levels is complex. Age, presence or absence of PCOS, the status of glucose metabolism like insulin resistance states, and potentially race may affect this interaction. The effect of weight loss on serum AMH levels is less clear. It is dependent on the above-mentioned factors, as well as the type of intervention like caloric restriction, physical activity, medical or surgical treatment. Consequently, despite the abundance of publications that study the relationship between obesity and AMH levels, the results are conflicting with lack of a consensus. Elucidation of the mechanisms of the effects of obesity states on serum AMH levels will improve our understanding of these complex interactions, potentially leading to discovery of therapies that may improve reproductive function.

UR - http://www.scopus.com/inward/record.url?scp=85060541079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060541079&partnerID=8YFLogxK

M3 - Chapter

SN - 9781634840125

SP - 263

EP - 280

BT - Anti-Müllerian Hormone

PB - Nova Science Publishers, Inc.

ER -