Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis

C. Ohadi, K. L. Litwin, H. Moreira, S. Kwitko, W. J. Gauderman, D. C. Gritz, A. Gwon, R. Jones, P. J. McDonnell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Corneal scarring as a consequence of bacterial keratitis is an important cause of visual loss and a major indication for penetrating keratoplasty. Anti-inflammatory agents might be useful in this condition for limiting corneal damage, but benefit from adjunctive anti-inflammatory therapy has never been demonstrated. In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-β-[(2-carboxyethyl) thio-α-hydroxy-2- (8-phenyloctyl) benzenepropanoic acid, zinc salt]. None of the anti- inflammatory agents prevented sterilization of ulcers with antibiotic (ofloxacin) therapy. Therapy with the leukotriene antagonist appeared to reduce infiltrate size more quickly and produce a more rapid reduction in lesion size, but the differences were not statistically significant. Sample size calculations suggest that very large numbers of animals would be required to prove efficacy. The role of anti-inflammatory agents in reducing the stromal destruction caused by bacterial keratitis remains controversial.

Original languageEnglish (US)
Pages (from-to)398-403
Number of pages6
JournalCornea
Volume11
Issue number5
StatePublished - 1992
Externally publishedYes

Fingerprint

Keratitis
Pseudomonas
Guinea Pigs
Anti-Inflammatory Agents
Leukotriene Antagonists
Masoprocol
Flurbiprofen
Lipoxygenase Inhibitors
Penetrating Keratoplasty
Ofloxacin
Cyclooxygenase Inhibitors
Therapeutics
Prednisolone
Sample Size
Ulcer
Cicatrix
Zinc
Adrenal Cortex Hormones
Salts
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ohadi, C., Litwin, K. L., Moreira, H., Kwitko, S., Gauderman, W. J., Gritz, D. C., ... McDonnell, P. J. (1992). Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis. Cornea, 11(5), 398-403.

Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis. / Ohadi, C.; Litwin, K. L.; Moreira, H.; Kwitko, S.; Gauderman, W. J.; Gritz, D. C.; Gwon, A.; Jones, R.; McDonnell, P. J.

In: Cornea, Vol. 11, No. 5, 1992, p. 398-403.

Research output: Contribution to journalArticle

Ohadi, C, Litwin, KL, Moreira, H, Kwitko, S, Gauderman, WJ, Gritz, DC, Gwon, A, Jones, R & McDonnell, PJ 1992, 'Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis', Cornea, vol. 11, no. 5, pp. 398-403.
Ohadi C, Litwin KL, Moreira H, Kwitko S, Gauderman WJ, Gritz DC et al. Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis. Cornea. 1992;11(5):398-403.
Ohadi, C. ; Litwin, K. L. ; Moreira, H. ; Kwitko, S. ; Gauderman, W. J. ; Gritz, D. C. ; Gwon, A. ; Jones, R. ; McDonnell, P. J. / Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis. In: Cornea. 1992 ; Vol. 11, No. 5. pp. 398-403.
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