Anti-inflammatory therapies for sensorineural hearing loss

Alanna M. Windsor, Michael J. Ruckenstein

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Anti-inflammatory and immunosuppressive therapies have been widely employed in the treatment of sensorineural hearing loss in the context of autoimmune inner ear disease (AIED) and idiopathic sudden sensorineural hearing loss (ISSHL). While steroids are the mainstay of treatment for these disorders, numerous other therapies, including cyclophosphamide, methotrexate, azathioprine, rituximab, anakinra, anti- TNF-α agents, and plasmapharesis have been investigated. Here we will describe the most commonly-studied of these immune-modulating therapies and review the evidence for their efficacy in the treatment of inner ear disorders, focusing on AIED and ISSHL. Further investigation of the potential inflammatory mechanisms mediating these forms of sensorineural hearing loss may ultimately identify targets for future treatments.

Original languageEnglish (US)
Title of host publicationInflammatory Mechanisms in Mediating Hearing Loss
PublisherSpringer International Publishing
Number of pages22
ISBN (Electronic)9783319925073
ISBN (Print)9783319925066
StatePublished - Jul 18 2018
Externally publishedYes


  • Autoimmune inner ear disease
  • Corticosteroids
  • Immunomodulation
  • Sensorineural hearing loss
  • Sudden hearing loss

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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